Rchr
J-GLOBAL ID：201601015645207204   Update date: Apr. 09, 2024

MIKAKO FUJITA

フジタ ミカコ | MIKAKO FUJITA
Affiliation and department：
Kumamoto University Research Institute for Drug Discovery

About Kumamoto University Research Institute for Drug Discovery


Homepage URL  (1)： http://www.pharm.kumamoto-u.ac.jp/Labs/bunsigouseiHP/
Research field  (2)： Pharmaceuticals - chemistry and drug development ,  Virology
Research keywords  (2)： 創薬 ,  エイズウイルス
Research theme for competitive and other funds  (19)：
  • 2023 - 2026 次世代ALS治療薬としてのエダラボン-c-Abl阻害剤ハイブリッドの創製
  • 2022 - 2025 神経線維腫症の神経系細胞異常分化と腫瘍化の責任因子シグナルと治療標的の解明
  • 2022 - 2025 Development of therapeutic drugs that tandemly suppress infection, lung fibrosis, and malignant transformation of the new coronavirus
  • 2020 - 2023 Structure optimization of compounds to confine HIV in a cell and induce apoptosis aiming at drugs
  • 2017 - 2020 Development of a method to induce apoptosis by HIV locked in a cell
Show all
Papers (145)：
  • Mostafa M Badran, Samar H Abbas, Hiroshi Tateishi, Yuki Maemoto, Tsugumasa Toma, Akihiro Ito, Mikako Fujita, Masami Otsuka, Mohamed Abdel-Aziz, Mohamed O Radwan. Ligand-based design and synthesis of new trityl histamine and trityl cysteamine derivatives as SIRT2 inhibitors for cancer therapy. European journal of medicinal chemistry. 2024. 269. 116302-116302
  • Teruya Nakamura, Chiaki Ohyama, Madoka Sakamoto, Tsugumasa Toma, Hiroshi Tateishi, Mihoko Matsuo, Mami Chirifu, Shinji Ikemizu, Hiroshi Morioka, Mikako Fujita, et al. TIFAB regulates the TIFA-TRAF6 signaling pathway involved in innate immunity by forming a heterodimer complex with TIFA. Proceedings of the National Academy of Sciences. 2024. 121. 11
  • Tsugumasa Toma, Nobukazu Miyakawa, Mika Tateishi, Mikio Todaka, Tatsuya Kondo, Mikako Fujita, Masami Otsuka, Eiichi Araki, Hiroshi Tateishi. An ADAM17 selective inhibitor promotes glucose uptake by activating AMPK. Journal of pharmacological sciences. 2024. 154. 1. 37-46
  • Hiroshi Tateishi, Takuma Chinen, Ryota Fukuda, Mohamed O Radwan, Kazunori Shimagaki, Ryoko Koga, Takashi Masuda, Yoshinari Okamoto, Arisa Sakamoto, Shogo Misumi, et al. HIV-1 Gag MA domain binds to cardiolipin in a binding mode distinct from virus assemble mediator PI(4,5)P2. Chemical biology & drug design. 2023. e14401
  • Omur Guven, Belgin Sever, Faika Başoğlu-Ünal, Abdulilah Ece, Hiroshi Tateishi, Ryoko Koga, Mohamed O Radwan, Nefise Demir, Mustafa Can, Mutlu Dilsiz Aytemir, et al. Structural Characterization of TRAF6 N-Terminal for Therapeutic Uses and Computational Studies on New Derivatives. Pharmaceuticals (Basel, Switzerland). 2023. 16. 11
ｍore...
MISC (2)：
  • 牧野雄成, 當眞嗣雅, 立石大, 藤田美歌子, 大塚雅巳, 大塚雅巳, 片岡良友. Molecular pathology of systemic sclerosis and molecular design of a therapeutic drug. Bio Clinica. 2022. 37. 9
  • Ali Taha, 岩丸 佳奈, Ciftci Halil, 古賀 涼子, 黒崎 博雅, 藤田 美歌子, 岡本 良成, 秀 拓一郎, 牧野 敬史, 倉津 純一, et al. 抗癌活性を持つ新規の金属キレート分子(Novel metal chelating molecules with anticancer activity). 日本薬学会年会要旨集. 2015. 135年会. 2. 137-137
Patents (20)：
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Lectures and oral presentations  (144)：
  • Fabrication of co-culture device for reproducing cancer metastasis behavior in vitro
    (The Proceedings of Conference of Kyushu Branch 2021)
  • HIV-1Gag MAドメインとカルジオリピン誘導体との結合解析
    (日本薬学会九州支部大会講演要旨集 2021)
  • HIV-1複製の後期過程を標的とした薬剤スクリーニング
    (日本エイズ学会誌 2021)
  • HIVリザーバーの除去または不活化を目指した新規治療法開発
    (日本エイズ学会誌 2020)
  • 癌転移をin vitroで再現するための肺胞上皮癌スフェロイド共培養デバイスの構築
    (化学とマイクロ・ナノシステム学会研究会講演要旨集 2020)
ｍore...
Education (3)：
  • 1993 - 1996 京都大学大学院 薬学研究科 博士後期課程
  • 1986 - 1988 University of Tsukuba
  • 1981 - 1985 Chiba University Faculty of Science Department of Chemistry
Professional career (1)：
  • 薬学博士 (京都大学)
Work history (5)：
  • 2019/04 - 現在 Kumamoto University
  • 2006/08 - 2019/03 Kumamoto University
  • 1999/10 - 2006/07 The University of Tokushima
  • 1998/04 - 1999/09 Kumamoto University
  • 1988/04 - 1993/03 財団法人 相模中央化学研究所
Committee career (1)：
  • 2018/05 - 現在 日本医療研究開発機構 プログラムオフィサー
Awards (1)：
  • 2012/12 - 日本薬学会九州支部 学術奨励賞
Association Membership(s) (6)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  THE JAPANESE ASSOCIATION FOR MOLECULAR TARGET THERAPY OF CANCER ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY FOR AIDS RESEARCH ,  THE JAPANESE SOCIETY FOR VIROLOGY ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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