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J-GLOBAL ID：201602270578892693   Reference number：16A0523626

A comparison of moxifloxacin-induced QTc interval prolongations between young and middle-aged males in a thorough QT/QTc Study

Thorough QT/QTc試験におけるモキシフロキサシンQT間隔延長作用の加齢による影響

Author (6)： NAGAI Masahiro (Ehime Univ. Graduate School of Medicine) ,  NAGAI Masahiro (Ehime Univ. Hospital) ,  IWAKI Hirotaka (Ehime Univ. Graduate School of Medicine) ,  TSUJII Tomoaki (Ehime Univ. Graduate School of Medicine) ,  NISHIKAWA Noriko (Ehime Univ. Graduate School of Medicine) ,  NOMOTO Masahiro (Ehime Univ. Graduate School of Medicine)
Material： 愛媛医学  (Ehime Medical Journal)
Volume： 35  Issue： 2  Page： 80-85  Publication year： Jun. 01, 2016 
JST Material Number： L2652A  ISSN： 0286-3677  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *new quinolone anti-bacterial agent ,...
Semi thesaurus term： *QTc prolongation ,...

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JST classification (1)： Clinical application of antibacterial drugs  (GW17030D)

Substance index (1)： Moxifloxacin

Reference (10)：

• Tamargo J : Drug-induced torsade de pointes : from molecular biology to bedside. Jpn J Pharmacol 2000 ; 83 : 1-19.
• Food and Drug Administration, HHS : International Conference on Harmonisation ; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs ; availability. Notice. Fed Regist 2005 ; 70 : 61134-35.
• Florian JA, Tornoe CW, Brundage R et al : Population pharmacokinetic and concentration-QTc models for moxifloxacin : pooled analysis of 20 thorough QT studies. J Clin Pharmacol 2011 ; 51 : 1152-62.
• Yan LK, Zhang J, Ng MJ et al : Statistical characteristics of moxifloxacin-induced QTc effect. J Biopharm Stat 2010 ; 20 : 497-507.
• Makkar R R, Fromm B S, Steinman R T et al : Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA 1993 ; 270: 2590-7.

Terms in the title (6)： QT ,  QTc ,  試験 ,  モキシフロキサシン ,  QT間隔延長 ,  加齢