Art

J-GLOBAL ID：201602286982015680   Reference number：16A0853348

Method validation of phosphorylated histone H2AX level detection using primary cultured hepatocytes in genotoxic agent screening

検出は細胞内リン酸化蛋白質のH2AX発現群遺伝毒物のスクリーニングに初代肝細胞モデルを利用し,この方法を検証した【JST・京大機械翻訳】

Author (7)： Meng Tao (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control) ,  Miao Panpan (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control) ,  Ji Yuqing (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control) ,  Niu Yong (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control) ,  Bin Ping (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control) ,  Dai Yufei (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control) ,  Zheng Yuxin (Key Laboratory of Chemical Safety and Health,National Institute of Occupational Health and Poison Control,Chinese Center for Disease Prevention and Control)
Material： Zhongguo Yaolixue yu Dulixue Zazhi  (Zhongguo Yaolixue Dulixue Zazhi)
Volume： 30  Issue： 2  Page： 135-143  Publication year： 2016 
JST Material Number： C2292A  ISSN： 1000-3002  CODEN： ZYYZEW  Document type： Article
Article type： 原著論文  Country of issue： China (CHN)  Language： CHINESE (ZH)

Abstract/Point： OBJECTIVE To establish an in v...

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Thesaurus term： *hepatocyte ,  flow cytometry ,  *heredity ,  oxidation ,  *phosphorylation ,  cytotoxicity ,  genetic toxicity ,  *phosphoprotein ,  blank ,  cholecystokinin ,  oligopeptide ,  aromatic hydrocarbon ,  vinyl compound
Semi thesaurus term： 蛍光強度 ,  コラゲナーゼ ,  初代肝細胞 ,  *ヒストンH2AX , 【Automatic Indexing@JST】

Author keywords (5)： genotoxic agents ,  hepatocytes ,  primary culture ,  histones ,  flow cytometry

JST classification (2)： Cell division and proliferation  (EF02020D) ,  Gene expression  (EC02040Q)

Substance index (2)： CCK-8 ,  Styrene

Terms in the title (9)： リン酸化蛋白質 ,  H2AX ,  発現 ,  遺伝 ,  毒物 ,  スクリーニング ,  初代肝細胞 ,  モデル ,  検証