Kowada Toshiyuki

コワダトシユキ | Kowada Toshiyuki

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： https://orcid.org/0000-0002-6623-6505

Research field (3)： Synthetic organic chemistry , Chemical biology , Biochemistry

Research keywords (2)： Chemical Biology , Biofunctional Chemistry

Research theme for competitive and other funds (15)：

2023 - 2026 オルガネラ間膜接触領域形成の光制御法の開発とイオン流動解析
2023 - 2024 オルガネラ間膜接触領域形成の生理的意義理解に向けた光操作化学ツールの開発
2022 - 2023 細胞小器官同士の膜接触領域の形成と解離を光制御する化学ツールの開発
2020 - 2023 環状リガンドの配座制御を基盤としたタンパク質局在の光制御法の開発
2020 - 2022 フッ素原子の特異な性質を利用した長波長蛍光色素群の網羅的合成と生命科学研究への応用

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Papers (27)：

Takao Fujisawa, Satoshi Takenaka, Lila Maekawa, Toshiyuki Kowada, Toshitaka Matsui, Shin Mizukami, Isao Naguro, Hidenori Ichijo. Zinc controls histone acetyltransferase KAT7 activity to maintain cellular zinc homeostasis. bioRxiv. 2023
Yusuke Matsui, Toshiyuki Kowada, Yi Ding, Priya Ranjan Sahoo, Kazuya Kikuchi, Shin Mizukami. Long-term Imaging of Intranuclear Mg²⁺ Dynamics during Mitosis Using a Localized Fluorescent Probe. Chemical Communications. 2023. 59. 7048-7051
Yuta Amagai, Momo Yamada, Toshiyuki Kowada, Tomomi Watanabe, Yuyin Du, Rong Liu, Satoshi Naramoto, Satoshi Watanabe, Junko Kyozuka, Tiziana Anelli, et al. Zinc homeostasis governed by Golgi-resident ZnT family members regulates ERp44-mediated proteostasis at the ER-Golgi interface. Nat. Commun. 2023. 14. 2683
Himadri S. Sarkar, Takato Mashita, Toshiyuki Kowada, Satoshi Hamaguchi, Toshizo Sato, Kento Kasahara, Nobuyuki Matubayasi, Toshitaka Matsui, Shin Mizukami. Arylazopyrazole-Based Photoswitchable Inhibitors Selective for Escherichia coli Dihydrofolate Reductase. ACS Chemical Biology. 2023. 18. 2. 340-346
Takato Mashita, Toshiyuki Kowada, Hayashi Yamamoto, Satoshi Hamaguchi, Toshitaka Matsui, Shin Mizukami. Quantitative and Repetitive Control of Subcellular Protein-Protein Interaction Using a Photochromic Dimerizer. ChemRxiv. 2022

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MISC (8)：

Toshiyuki Kowada. 生細胞内タンパク質の局在を自在に操る-タンパク質ラベル化の光制御法の開発. CHEMISTRY & CHEMICAL INDUSTRY. 2024. 77-1. 034-035
小和田俊行. 若手研究者からのメッセージ. 日本化学会バイオテクノロジー部会NEWS LETTER. 2022. 25. 2. 15-20
Toshiyuki Kowada. 細胞小器官内遊離Zn2+の濃度定量と動態観察を可能とする小分子蛍光プローブの開発. 2021. 36. 2. 4-9
Toshiyuki Kowada. 合成小分子と光の力で細胞内蛋白質の局在を自在に操る!. 2021
小和田俊行. 化学フロンティア研究会-化学を楽しむ人びとが集まる合宿形式の講演会. 月刊「化学」. 2021. 76. 4. 30-32

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Books (5)：

Fluorescent Chemosensors
Royal Society of Chemistry 2023 ISBN:9781839163869
Live Cell Imaging: Methods and Protocols (Methods in Molecular Biology)
Humana (Springer, New York, US) 2021
実験医学増刊「生きてるものは全部観る!イメージングの選び方・使い方100+」
Yodosha 2018
Optical Probes in Biology, Edited by Jin Zhang, Sohum Mehta, Carsten Schultz
CRC Press 2015 ISBN:9781466510111
実験医学別冊「in vivo イメージング実験プロトコール原理と導入のポイントから 2光子顕微鏡の応用まで」
Yodosha Company Limited 2012 ISBN:9784758101851

Lectures and oral presentations (91)：

細胞内金属イオンの可視化・定量・操作
(メタルバイオサイエンス研究会2023 2023)
Development of photo-degradation technology of tag-fused proteins
(2023)
Optical regulation of protein-protein interactions in living cells using a photochromic dimerizer
(6th Asian Chemical Biology Conference 2023 (ACBC2023) 2023)
Development of fluorescent probes to detect sulfatase 2 activity for tumor imaging
(Tohoku University's Chemistry Summer School 2023 2023)
Development of fast-blinking fluorophores for real-time single-molecule super-resolution imaging
(Tohoku University's Chemistry Summer School 2023 2023)

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Education (2)：

2005 - 2010 Kyoto University Graduate School, Division of Engineering Department of Energy and Hydrocarbon Chemistry
2001 - 2005 Kyoto University Faculty of Engineering Division of Industrial Chemistry

Professional career (1)：

博士(工学) (Kyoto University)

Work history (6)：

2023/07 - 現在 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Associate Professor
2023/02 - 現在 Tohoku University
2016/11 - 2023/06 Tohoku University Institute of Multidisciplinary Research for Advanced Materials Assistant Professor
2014/10 - 2016/10 School of medicine, Stanford University, USA Postdoctoral Fellow
2011/04 - 2014/09 WPI Immunology Frontier Research Center, Osaka University, Japan Specially appointed assistant professor

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Committee career (7)：

2022/11 - 現在 UW- TU:AOS (University of Washington - Tohoku University : Academic Open Space) 化学分科会委員
2012/03 - 現在化学フロンティア研究会運営委員代表
2019/09 - 2021/08 日本化学会生体機能関連化学部会若手の会第32回サマースクール世話人代表
2019/03 - 2021/02 日本化学会生体機能関連化学部会若手幹事
2019/03 - 2020/02 日本化学会生体機能関連化学部会若手幹事代表

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Awards (6)：

2023/03 - The Chemical Society of Japan “Young Scholar Lecture” in the 103rd CSJ Annual Meeting (2023)
2023/01 - Konica Minolta Science and Technology Foundation Young Scientist Award in Image Science
2021/09 - Division of Biofunctional Chemistry & Division of Biotechnology, The Chemical Society of Japan バイオ関連化学シンポジウム講演賞 Development of small-molecule fluorescent probes for quantification of labile Zn2+ concentration and monitoring of Zn2+ dynamics in organelles
2019/12 - The Society of Synthetic Organic Chemistry. Japan Award for Research Proposal
2019/09 - Bioimaging Society Young Research Award

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Association Membership(s) (7)：

Chemical Frontier Workshop , Bioimaging Society , The Society of Synthetic Organic Chemistry, Japan , Japanese Society for Chemical Biology , Division of Biofunctional Chemistry, The Chemical Society of Japan , Chemical Society of Japan , 日本分子イメージング学会

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