Rchr
J-GLOBAL ID:201701014624038179
Update date: Jan. 04, 2024
Mizunoe Yuhei
ミズノエ ユウヘイ | Mizunoe Yuhei
Research field (3):
Nutrition and health science
, Pharmaceuticals - health and biochemistry
, Metabolism and endocrinology
Research keywords (11):
カテプシン
, リソソーム
, コレステロール
, 脂質異常症
, 脂肪細胞
, ミトコンドリア
, 二型糖尿病
, 骨格筋
, 老化
, オートファジー
, 脂肪組織
Research theme for competitive and other funds (5):
- 2023 - 2025 ”免疫様脂肪細胞”によるリソソーム機能障害と肥満症病態基盤の形成
- 2019 - 2022 骨格筋でのコレステロール合成阻害が導く新たなコレステロール代謝機構
- 2018 - 2021 加齢によるリソソーム機能破綻が骨格筋に及ぼす影響の解明とその制御法の開発
- 2019 - 2020 骨格筋特異的コレステロール破綻が横紋筋融解症を発症させる分子メカニズムの解明
- 2017 - 2018 サルコペニアにおける筋繊維タイプ変化・代謝変換とオートファジー相互作用機構の解明
Papers (27):
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Kazuki Hachiya, Yusuke Deguchi, Takuro Hirata, Tomoya Arikawa, Hiroto Fukai, Tatsuhiro Esashi, Kota Nagasawa, Yuhei Mizunoe, Yuka Nozaki, Masaki Kobayashi, et al. Obesity-induced PARIS (ZNF746) accumulation in adipose progenitor cells leads to attenuated mitochondrial biogenesis and impaired adipogenesis. Scientific reports. 2023. 13. 1. 22990-22990
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Song-Iee Han, Masanori Nakakuki, Yoshimi Nakagawa, Yunong Wang, Masaya Araki, Yuta Yamamoto, Hiroaki Tokiwa, Hiroyuki Takeda, Yuhei Mizunoe, Kaori Motomura, et al. Rhomboid protease RHBDL4/RHBDD1 cleaves SREBP-1c at endoplasmic reticulum monitoring and regulating fatty acids. PNAS nexus. 2023. 2. 11. pgad351
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Yuina Otani, Yuka Nozaki, Yuhei Mizunoe, Masaki Kobayashi, Yoshikazu Higami. Effect of mitochondrial quantity and quality controls in white adipose tissue on healthy lifespan: Essential roles of GH/IGF-1-independent pathways in caloric restriction-mediated metabolic remodeling. Pathology international. 2023
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Nurani Istiqamah, Takashi Matsuzaka, Momo Shimizu, Kaori Motomura, Hiroshi Ohno, Shiho Hasebe, Rahul Sharma, Yuka Okajima, Erika Matsuda, Song-Iee Han, et al. Identification of key microRNAs regulating ELOVL6 and glioblastoma tumorigenesis. BBA Advances. 2023. 3. 100078-100078
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Masaya Araki, Yoshimi Nakagawa, Hodaka Saito, Yasunari Yamada, Song-Iee Han, Yuhei Mizunoe, Hiroshi Ohno, Takafumi Miyamoto, Motohiro Sekiya, Takashi Matsuzaka, et al. Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease. American journal of physiology. Gastrointestinal and liver physiology. 2022. 323. 6. G627-G639
more...
MISC (3):
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Regulation of adipocyte quality by lysosomes and mitochondria. 2021. 45. 1. 31-37
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Yuhei Mizunoe, Yuka Sudo, Naoyuki Okita, Yoshikazu Higami. Autophagy in adipose tissue AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 9 to be published by Elsevier/Academic Press. Autophagy, M.A.HAYAT (ed). 2016. 10. 147-156
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水之江 雄平, 須藤 結香, 平岡 秀規, 沖田 直之, 樋上 賀一. 肥満症脂肪組織におけるリソソーム機能障害とオートファジーに与える影響. 基礎老化研究. 2015. 39. 3. 35-38
Lectures and oral presentations (14):
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Lysosomal dysfunction in obese adipose tissue
(30th Spring International Conference of the Korean Society for Gerontology 2019)
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肥満症脂肪組織における脂肪滴局在タンパク質ペリリピン1減少のメカニズム解明(ポスター)
(第42回日本基礎老化学会大会 2019)
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臓器特異的SREBP-1a欠損マウスを用いたSREBP-1aの肝臓における機能解(ポスター)
(第56回日本臨床分子医学会学術集会 2019)
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新規プロテアーゼによるSREBP-1活性化制御機構の解明(ポスター)
(第56回日本臨床分子医学会学術集会 2019)
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脂肪酸伸長酵素Elovl6の神経新生における役割(ポスター)
(第56回日本臨床分子医学会学術集会 2019)
more...
Professional career (1):
Work history (4):
- 2023/04 - 現在 Tokyo University of Science Faculty of Pharmaceutical Sciences Department of Medicinal and Life Science Assistant Professor
- 2022/04 - 2023/03 Tokyo University of Science Organization for Research Advancement Research Institute for Biomedical Science
- 2019/04 - 2022/03 日本学術振興会 特別研究員PD
- 2018/04 - 2019/03 Faculty of Medicine, University of Tsukuba Department of Internal Medicine (Endocrinology and Metabolism)
Committee career (1):
- 2023/03 - 現在 日本基礎老化学会 評議員
Awards (1):
Association Membership(s) (4):
日本動脈硬化学会
, 日本免疫学会
, JAPAN SOCIETY FOR THE STUDY OF OBESITY
, JAPAN SOCIETY FOR BIOMEDICAL GERONTOLOGY
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