Masanori Nagatomo

ナガトモマサノリ | Masanori Nagatomo

Affiliation and department：
Job title： Professor
Homepage URL (2)： https://www.pharm.hokudai.ac.jp/tengo_105/ , https://www.pharm.hokudai.ac.jp/tengo_105/home-en/

Research field (4)： Bioorganic chemistry , Structural/physical organic chemistry , Synthetic organic chemistry , Pharmaceuticals - chemistry and drug development

Research keywords (5)： Organic Synthetic Chemistry , Natural Product Synthesis , Taotal Synthesis , Photochemistry , Computational Chemistry

Research theme for competitive and other funds (13)：

2022 - 2025 Unified total synthesis of the unexplored densely oxygenated daphnane diterpenes for drug lead discovery
2022 - 2024 Development of Innovative Photoreactions with MI Implementation: Presentation and Realization of an Unexplored Retrosynthetic Strategy for Highly Oxidized Natural Products
2022 - 2023 Toward the Total Synthesis of Trigocherrins
2017 - 2022 Application of hybrid catalysis-mediated multi-component coupling reactions for efficient construction of densely functionalized natural products
2017 - 2022 Expanding the medicinally relevant chemical space with architecturally complex natural products and their synthetic analogues

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Papers (50)：

Ayumu Watanabe, Masanori Nagatomo, Akira Hirose, Yuto Hikone, Naoki Kishimoto, Satoshi Miura, Tae Yasutake, Towa Abe, Shogo Misumi, Masayuki Inoue. Total Syntheses of Phorbol and 11 Tigliane Diterpenoids and Their Evaluation as HIV Latency-Reversing Agents. Journal of the American Chemical Society. 2024. 146. 12. 8746-8756
Yuto Hikone, Masanori Nagatomo, Masayuki Inoue. Development of Streamlined Processes for Construction of Complex Natural Products: Three Total Syntheses of Resiniferatoxin. Journal of Synthetic Organic Chemistry, Japan. 2023. 81. 12. 1136-1149
Takahiro Watanabe, Kyohei Oga, Hiroaki Matoba, Masanori Nagatomo, Masayuki Inoue. Total Synthesis of Taxol Enabled by Intermolecular Radical Coupling and Pd-Catalyzed Cyclization. Journal of the American Chemical Society. 2023
Yibin Xue. α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis. Organic Syntheses. 2023. 100. 99-112
Yusuke Imamura, Kyohei Takaoka, Yuma Komori, Masanori Nagatomo, Masayuki Inoue. Total Synthesis of Taxol Enabled by Inter- and Intramolecular Radical Coupling Reactions. Angewandte Chemie. 2023

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MISC (67)：

今村祐亮, 高岡恭兵, 長友優典, 井上将行. タキソールの全合成. 有機合成シンポジウム講演予稿集. 2022. 121st
Maria Varghese, Hannah E. Caputo, Ruiqing Xiao, Anant Balijepalli, Aladin Hamoud, Mark W. Grinstaff, Checked by Kyohei Oga, Masanori Nagatomo, Masayuki Inoue. Stereoselective [2+2] Cycloadditions: Synthesis of a Tri-O-Bn-D-Glucal-derived β-Lactam. Organic Syntheses. 2021. 98. 491-508
高岡恭兵, 今村祐亮, 長友優典, 井上将行. タキソールCD環部の合成研究. 日本薬学会関東支部大会講演要旨集. 2021. 65th (CD-ROM)
長友優典, 桑名大輝, 井上将行. TiO₂を用いた脱炭酸型ラジカルカップリング反応の開発による高酸化度化合物の構築. 反応と合成の進歩シンポジウム講演要旨集. 2021. 47th
渡邉歩, 廣瀬哲, 長友優典, 井上将行. レジニフェラトキシンの短工程全合成. 次世代を担う有機化学シンポジウム講演要旨集. 2021. 19th

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Books (13)：

Exploration of the Unified Total Synthetic Strategies-Unraveling and Assembling Privileged Structures
The Chemical Society of Japan 2023
Total Syntheses of Densely Oxygenated Natural Products by Radical-Based Decarbonylative Convergent Assembly
Springer 2023 ISBN:9789819917136
抗がん剤タキソールの全合成--ラジカル反応を活用した新しい合成戦略とその展開
化学同人 2023
α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
Organic Syntheses, Inc. 2023
Stereoselective [2+2] Cycloadditions: Synthesis ofa Tri-O-Bn-D-Glucal-derived β-Lactam
Organic Syntheses, Inc. 2021

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Education (4)：

2009 - 2012 The University of Tokyo Graduate School of Pharmaceutical Sciences Department of Integrated Pharmaceutical Sciences
2007 - 2009 Tokyo University of Science Graduate School of Science Department of Chemistry
2003 - 2007 Tokyo University of Science Faculty of Science, Division 1 Department of Applied Chemistry
1999 - 2002 Miyazaki Prefectural Miyazaki Nishi High School Science and Mathematics Course

Professional career (1)：

Ph.D. (The University of Tokyo)

Work history (6)：

2023/11 - 現在 Hokkaido University Faculty of Pharmaceutical Sciences Professor
2021/10 - 2023/10 The University of Tokyo Excellent Young Researcher
2018/11 - 2023/10 The University of Tokyo Graduate School of Pharmaceutical Sciences Lecturer
2012/04 - 2018/10 The University of Tokyo Graduate School of Pharmaceutical Sciences Assistant Professor
2012/07 - 2012/08 The Scripps Research Institute San Diego, California Research Fellow

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Committee career (2)：

2018/04 - 現在 Colloquium of natural product chemistry manager
2018/04 - 現在天然物化学談話会世話人

Awards (8)：

2023/03 - The Chemical Society of Japan 37th Young Scholar Lecture Award Unified Total Synthesis of Daphnane, Tigliane, and Rhamnopholane Diterpenoids
2021/12 - The Society of Synthetic Organic Chemistry, Japan Daiichi Sankyo Research Proposal Award
2021/10 - The University of Tokyo The University of Tokyo Excellent Young Researcher Simplification of the Synthesis of Densely Oxygenated Bioactive Natural Products Based on Radical Synthetic Strategies
2019/12 - MSD Life Science Foundation, Public Interest Incorporated Foundation Chemist Award BCA 2019 Development of novel C-C bond formation reactions utilizing α-alkoxy and α-amino carbon radical and application to the total synthesis of densely oxygenated natural products
2019/01 - Thieme Publishing Group The Thieme Chemistry Journals Award 2019

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Association Membership(s) (5)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , THE CHEMICAL SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , Japan Society for Bioscience, Biotechnology, and Agrochemistry , The Japanese Society of Pharmacognosy

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