Art

J-GLOBAL ID：201702238462396231   Reference number：17A0401568

Artemisinins Target GABA_A Receptor Signaling and Impair α Cell Identity

Artemisininsは,GABA_A受容体シグナル伝達を標的とするとα細胞同一性を障害する【Powered by NICT】

Author (48)： Li Jin (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Casteels Tamara (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Frogne Thomas (Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark) ,  Ingvorsen Camilla (Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark) ,  Honore Christian (Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark) ,  Courtney Monica (Universite Cote d’Azur, INSERM, CNRS, iBV, 06108 Nice, France) ,  Huber Kilian V.M. (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Schmitner Nicole (Institute of Molecular Biology, Leopold-Franzens-University Innsbruck, Technikerstr. 25, 6020 Innsbruck, Austria) ,  Kimmel Robin A. (Institute of Molecular Biology, Leopold-Franzens-University Innsbruck, Technikerstr. 25, 6020 Innsbruck, Austria) ,  Romanov Roman A. (Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria) ,  Romanov Roman A. (Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden) ,  Sturtzel Caterina (Children’s Cancer Research Institute, Innovative Cancer Models, Zimmermannplatz 10, 1090 Vienna, Austria) ,  Lardeau Charles-Hugues (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Lardeau Charles-Hugues (Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria) ,  Klughammer Johanna (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Farlik Matthias (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Sdelci Sara (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Vieira Andhira (Universite Cote d’Azur, INSERM, CNRS, iBV, 06108 Nice, France) ,  Avolio Fabio (Universite Cote d’Azur, INSERM, CNRS, iBV, 06108 Nice, France) ,  Briand Francois (Physiogenex S.A.S., Prologue Biotech, 516, rue Pierre et Marie Curie, 31670 Labege, France) ,  Baburin Igor (Institute of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria) ,  Majek Peter (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Pauler Florian M. (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Penz Thomas (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Stukalov Alexey (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Gridling Manuela (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Parapatics Katja (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Barbieux Charlotte (Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland) ,  Berishvili Ekaterine (Cell Isolation and Transplantation Center, Department of Surgery, Geneva University Hospitals and University of Geneva, 1211 Geneva, Switzerland) ,  Berishvili Ekaterine (Institute of Medical Research, Ilia State University, Tbilisi 0162, Georgia) ,  Spittler Andreas (Core Facility Flow Cytometry and Department of Surgery, Research Laboratories, Medical University of Vienna, 1090 Vienna, Austria) ,  Colinge Jacques (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Bennett Keiryn L. (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Hering Steffen (Institute of Pharmacology and Toxicology, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria) ,  Sulpice Thierry (Physiogenex S.A.S., Prologue Biotech, 516, rue Pierre et Marie Curie, 31670 Labege, France) ,  Bock Christoph (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Bock Christoph (Department of Laboratory Medicine, Medical University of Vienna, 1090 Vienna, Austria) ,  Bock Christoph (Max Planck Institute for Informatics, 66123 Saarbruecken, Germany) ,  Distel Martin (Children’s Cancer Research Institute, Innovative Cancer Models, Zimmermannplatz 10, 1090 Vienna, Austria) ,  Harkany Tibor (Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria) ,  Harkany Tibor (Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden) ,  Meyer Dirk (Institute of Molecular Biology, Leopold-Franzens-University Innsbruck, Technikerstr. 25, 6020 Innsbruck, Austria) ,  Superti-Furga Giulio (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Superti-Furga Giulio (Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria) ,  Collombat Patrick (Universite Cote d’Azur, INSERM, CNRS, iBV, 06108 Nice, France) ,  Hecksher-Sorensen Jacob (Novo Nordisk A/S, Novo Nordisk Park, DK-2760 Malov, Denmark) ,  Kubicek Stefan (CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences. Lazarettgasse 14, 1090 Vienna, Austria) ,  Kubicek Stefan (Christian Doppler Laboratory for Chemical Epigenetics and Antiinfectives, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Lazarettgasse 14, 1090 Vienna, Austria)
Material： Cell (Cambridge, Mass.)  (Cell (Camb. Mass.))
Volume： 168  Issue： 1-2  Page： 86-100.e15  Publication year： 2017 
JST Material Number： A0707B  ISSN： 0092-8674  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Type 1 diabetes is characteriz...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=17A0401568&from=J-GLOBAL&jstjournalNo=A0707B") }}

Thesaurus term： new drug ,  Glucagon ,  type 1 diabetes mellitus ,  small molecule ,  regenerative medicine ,  antimalarial drug ,  human ,  *Islets of Langerhans ,  Diabetes Mellitus ,  Danio rerio ,  Cytoplasm ,  gephyrin ,  Cell Transdifferentiation ,  pancreatic cell ,  cell type

Author keywords (10)： artemisinins ,  GABA-receptor signaling ,  gephyrin ,  pancreatic endocrine transdifferentiation ,  ARX translocation ,  β cell ,  insulin secretion ,  diabetes ,  regenerative medicine ,  chemical biology

JST classification (1)： Cell physiology in general  (EF02010S)

Terms in the title (5)： 受容体 ,  シグナル伝達 ,  標的 ,  細胞 ,  障害