SAITO SHINICHIRO

Research field (3)： Cell biology , Experimental pathology , Immunology

Research keywords (5)： Autoimmune Disease , plasmacytoid DC (pDC) , Dendritic Cell (DC) , Nucleic Acid-Sensing TLR , Toll-like Receptor (TLR)

Research theme for competitive and other funds (14)：

2020 - 2023 Elucidation of the onset mechanism of Type 2 Autoimmune Hepatitis and related liver diseases
2020 - 2022 Elucidation of the mechanisms using different response zones in endosome and lysosome by nucleic acid-sensing Toll-like receptors
2018 - 2020 Elucidation of response zones for nucleic acid-sensing Toll-like receptors
2016 - 2018 Elusidation of regulatory mechanism for regulatory Tcells by Arl8b
2014 - 2018 A role of Arl8b for the development of SLE

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Papers (68)：

Sajid Iftekhar Chowdhury, Masanori Inui, Tatsuya Yamazaki, Susumu Tomono, Hidekazu Takagi, Mrityunjoy Biswas, Shin-Ichiroh Saitoh, Kensuke Miyake, Sachiko Akashi-Takamura. The anti-TLR4 monoclonal antibody Sa15-21 enhances inflammatory cytokine production in LPS -stimulated macrophages. FEBS Letters. 2023
Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. JOURNAL OF EXPERIMENTAL MEDICINE. 2022. 220. 9
Kensuke Miyake, Takuma Shibata, Ryutaro Fukui, Ryota Sato, Shin-Ichiroh Saitoh, Yusuke Murakami. Nucleic Acid Sensing by Toll-Like Receptors in the Endosomal Compartment. Frontiers in immunology. 2022. 13. 941931-941931
Kensuke Miyake, Shin-Ichiroh Saitoh, Ryutaro Fukui, Takuma Shibata, Ryota Sato, Yusuke Murakami. Dynamic control of nucleic-acid-sensing Toll-like receptors by the endosomal compartment. International immunology. 2021. 33. 12. 835-840
Ryota Sato, Tatjana Reuter, Ryosuke Hiranuma, Takuma Shibata, Ryutaro Fukui, Yuji Motoi, Yusuke Murakami, Hiroki Tsukamoto, Satoshi Yamazaki, Kaiwen Liu, et al. The impact of cell maturation and tissue microenvironments on the expression of endosomal Toll-like receptors in monocytes and macrophages. International immunology. 2020. 32. 12. 785-798

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MISC (121)：

齋藤伸一郎. 細胞内オルガネラを介した神経系と免疫系の制御機構樹状細胞のエンドソーム異常による2型自己免疫性肝炎と原発性胆汁性胆管炎の発症. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 1S16m-06
SAITOH Shin-Ichiroh, HARADA Kenichi, MORI-SAITOH Yoshiko, SUN-WADA Ge-Hong, DENDA Tamami, OTA Yasunori, SAGARA Hiroshi, WATANABE Yuji, WADA Yoh, MIYAKE Kensuke, et al. Endosomal abnormalities in dendritic cells cause autoimmune liver diseases. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
SHIBATA Takuma, RYOTA Sato, SHIN-ICHIROH Saitoh, MIYAKE Kensuke. TLR7 stress response drives histiocytosis in SLC29A3 disorders. 日本免疫学会総会・学術集会記録(CD-ROM). 2022. 51
齋藤伸一郎. 樹状細胞のエンドソーム異常によりαβT細胞とγδT細胞を活性化することで自己免疫性肝炎と原発性胆汁性胆管炎を引き起こす. 日本エンドトキシン・自然免疫研究会プログラム・抄録集. 2022. 27th (Web)
SAITOH Shin-Ichiroh, SAITOH-MORI Yoshiko, MIYAKE Kensuke. Loss of Rab7a in dendritic cells causes type 2 autoimmune hepatitis and primary biliary cholangitis. 日本免疫学会総会・学術集会記録(CD-ROM). 2021. 50

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Books (5)：

Lectures and oral presentations (20)：

ADP-ribosylation factor-like 8b is required for the pathogenesis of mouse models of Systemic Lupus Erythematosus
(2017)
Arl8bは全身性エリテマトーデスモデルマウスBXSB.Yaaの病気の発症に関わっている.
(第23回日本エンドトキシン・自然免疫研究会 2017)
Metabolic permission for IFNa induction is connected by Toll-like Receptor 7 trafficking
(第45回日本免疫学会学術集会 2016)
Toll-like receptor 7の移動は代謝センサーmTorC1による1型インターフェロン産生の制御と結びついている.
(第22回日本エンドトキシン・自然免疫研究会 2016)
The Arf-like GTPase Arl8b drives TLR7 into type I interferon-mediated inflammation
(2013)

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Professional career (1)：

Work history (1)：

2023/04 - 現在 Institute of Advanced Medicine, Wakayama Medical University Department of Intractable Disorders Professor

Committee career (1)：

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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