Kato Takuma

カトウタクマ | Kato Takuma

Affiliation and department：
Job title：助教

Research field (3)： Structural biochemistry , Chemical biology , Pharmaceuticals - chemistry and drug development

Research keywords (4)：ケミカルバイオロジー , X線結晶構造 , 医薬品化学 , ペプチド化学

Research theme for competitive and other funds (2)：

2017 - 2019 Development of cell penetrating peptide utilizing the charactaristic of disubstituted amino acid
2015 - 2018 非天然型アミノ酸を利用した膜透過性ペプチドの創製とそのDDSキャリアとしての応用

Papers (26)：

Akiko Asano, Yukiko Kawanami, Mao Fujita, Yuta Yano, Rio Ide, Katsuhiko Minoura, Takuma Kato, Mitsunobu Doi. Electronic substituent effect on the conformation of a phenylalanine-incorporated cyclic peptide. RSC Advances. 2024
Takahito Ito, Hidetomo Yokoo, Takuma Kato, Mitsunobu Doi, Yosuke Demizu. Sculpting Secondary Structure of a Cyclic Peptide: Conformational Analysis of a Cyclic Hexapeptide Containing a Combination of l-Leu, d-Leu, and Aib Residues. ACS Omega. 2023
Akiko Asano, Mizuki Sakata, Takuma Kato, Mitsunobu Doi. Puckering of 4-Fluoro-L-proline Isomers and 4,4-Difluoro-L-proline Influencing Conformation of Ornithine-free Gramicidin S. Chemistry Letters. 2023. 52. 4. 246-248
Takuma Kato, Hiroaki Numa, Mihoko Nakamachi, Akiko Asano, Mitsunobu Doi. Effects of Substituting Disubstituted Amino Acids into the Amphipathic Cell Penetrating Peptide Pep-1. Chemical and Pharmaceutical Bulletin. 2022. 70. 11. 812-817
Hidetomo Yokoo, Takashi Misawa, Takuma Kato, Masakazu Tanaka, Yosuke Demizu, Makoto Oba. Development of delivery carriers for plasmid DNA by conjugation of a helical template to oligoarginine. Bioorganic & medicinal chemistry. 2022. 72. 116997-116997

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MISC (27)：

加藤巧馬, 出水庸介, 田中正一, 浅野晶子, 土井光暢. Evaluation of the effect of the type of disubstituted amino acids on the peptide secondary structure in a heteropeptide of leucine and disubstituted amino acids. 日本薬学会年会要旨集(Web). 2023. 143rd
佐藤和樹, 梅野智大, 上田篤志, 土井光暢, 加藤巧馬, 田中正一. N末をチオウレアで修飾したヘリカルペプチド触媒による不斉マイケル付加反応. 創薬懇話会講演要旨集. 2021. 2021
真倉唯, 上田篤志, 梅野智大, 加藤巧馬, 平山和浩, 土井光暢, 大庭誠, 田中正一. E-selective ring-closing metathesis for i, i+4 stapled peptides. 日本薬学会年会要旨集(Web). 2021. 141st
佐藤和樹, 梅野智大, 上田篤志, 土井光暢, 加藤巧馬, 田中正一. Asymmetric 1,4-addition reactions using N-terminal thiourea-modified helical peptide-catalysts. 日本薬学会年会要旨集(Web). 2021. 141st
真倉唯, 上田篤志, 梅野智大, 加藤巧馬, 平山和浩, 土井光暢, 大庭誠, 田中正一. E-Selective peptide-stapling using five-membered ring carbocyclic amino acids. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)

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Lectures and oral presentations (51)：

Development of amphipathic cell penetrating peptide based on Pep-1 sequence
(2020)
pep-1ペプチドをモデル配列としたジ置換アミノ酸導入膜透過性ペプチドの創製と評価
(第70回日本薬学会関西支部大会 2020)
Development of cell-penetrating peptides having disubstituted amino acids based on Pep-1 sequence
(2020)
Cell Permeability Evaluation of Helical Cell Penetrating Ppeptides Using Cyclic Disubstituted Amino Acids Having Basic Functional Groups
(2019)
アシジアサイクラマイドPhe誘導体のハロゲン置換によるコンフォメーションへの影響
(第69回日本薬学会関西支部総会・大会 2019)

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Education (2)：

Work history (3)：

2018/04 - 現在 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences
2017/04 - 2018/03 Osaka University of Pharmaceutical Sciences Faculty of Pharmaceutical Sciences
2015/04 - 2017/03 日本学術振興会特別研究員 DC1

Association Membership(s) (3)：

THE PHARMACEUTICAL SOCIETY OF JAPAN , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , The Japanese Peptide Society

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