Research field (2):
Functional biochemistry
, Cell biology
Research keywords (3):
出芽酵母
, オートファジー
, ミトコンドリア
Research theme for competitive and other funds (16):
2020 - 2022 Regulatory mechanisms of protein-protein interactions acting as a mitophagy initiation site
2019 - 2022 Regulatory mechanisms of selective mitochondrial degradation via ubiquitin-related pathways
2019 - 2022 Diverse molecular mechanisms regulating selective mitochondria degradation
2016 - 2019 Elucidating the molecular mechanisms of selective mitochondrial degradation
2016 - 2018 マイトファジー誘導時に駆動されるミトコンドリア分裂の分子基盤
2015 - 2017 新生鎖のN末端アセチル化を介したミトコンドリアの恒常性制御
2014 - 2017 Novel conjugation of the ubiquitin-like protein Atg8 and its biological significance
2013 - 2017 Regulatory mechanisms and molecular bases of selective mitochondria degradation
2014 - 2016 選択的オルガネラ・オートファジーの分子機構
2013 - 2016 Generation of an eukaryote harboring genes transferred from mitochondria to the nucleus
2011 - 2013 ESCRTーIIIタンパク質によるミトコンドリア分解の制御
2011 - 2012 Establishmentof tools regulating mitophagyby chemical biology
2010 - 2012 Biochemical screen and functional analysis of a protein complexrequired for selective degradation of mitochondria
2010 - 2011 ミトコンドリア分解制御タンパク質の作用機構と生理機能
2008 - 2010 Genome-wide screen and functional analysis of novel factors required for selective degradation of mitochondria
2008 - 2009 選択的マイトファジーに必須なタンパク質のミトコンドリア標的化機構
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Papers (52):
Toan Khanh Le, Yasuhiro Hirano, Haruhiko Asakawa, Koji Okamoto, Tatsuo Fukagawa, Tokuko Haraguchi, Yasushi Hiraoka. A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis. Journal of Cell Science. 2023. jcs.260930
Mashun Onishi, Mitsutaka Kubota, Lan Duan, Yuan Tian, Koji Okamoto. The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex. Life Science Alliance. 2023. 6. 4. e202201640-e202201640
Schuster R, Okamoto K. An overview of the molecular mechanisms of mitophagy in yeast. Biochimica et Biophysica Acta - General Subjects. 2022
Kubota M, Okamoto K. The protein N-terminal acetyltransferase A complex contributes to yeast mitophagy via promoting expression and phosphorylation of Atg32. J Biochem. 2021. 170. 2. 175-182
Mashun Onishi, Koji Okamoto. The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex. 2021
Locking and unlocking mechanisms for mitophagy initiation in budding yeast
(Cold Spring Harbor Asia Conference on Mitochondria and Metabolism in Health and Disease)
Extracellular export of RNA-derived modified nucleosides in budding yeast
(Cold Spring Harbor Asia Conference on Mitochondria and Metabolism in Health and Disease 2023)
ミトコンドリアを無標識で可視化する
(第20回日本ミトコンドリア学会年会 2021)
Endoplasmic reticulum-related pathways act in mitochondrial clearance
(2021)
Regulation of mitophagy via endoplasmic reticulum membrane- bound factors
(The Cold Spring Harbor Asia conference on Mitochondria and Metabolism in Health and Disease 2019)
1986 - 1990 Hiroshima University Faculty of Science
Professional career (1):
博士(理学) (広島大学)
Work history (9):
2015/07 - 現在 大阪大学大学院 生命機能研究科 准教授
2010/04 - 2015/06 大阪大学大学院 生命機能研究科 特任准教授(常勤)
2009/04 - 2010/03 Tokyo Institute of Technology
2006/12 - 2009/03 National Institute for Basic Biology
2005/02 - 2006/11 ユタ大学 医学部生化学科 研究助教授
2002/01 - 2005/02 ユタ大学生物学科 研究助教授
1999/09 - 2002/01 ミュンヘン大学生理化学研究所 研究員
1996/07 - 1999/06 テキサス大学サウスウェスタンメディカルセンター 研究員
1995/05 - 1996/06 東北大学遺伝生態研究センター COE研究員
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Association Membership(s) (6):
酵母研究会
, 酵母遺伝学フォーラム
, THE JAPANESE SOCIETY OF MITOCHONDRIAL RESEARCH AND MEDICINE
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
, 日本細胞生物学会