Mochida Yuki

モチダユウキ | Mochida Yuki

Affiliation and department：
Job title： Junior Associate Professor
Other affiliations (1)：

Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine Dupty Principal Research Scientist

Research field (7)： Biomedical engineering , Polymer chemistry , Clinical pharmacy , Pharmaceuticals - analytical and physicochemistry , Polymer materials , Biochemistry , Analytical chemistry

Research keywords (10)：ドラッグデリバリーシステム , protein delivery , mRNA delivery , がん免疫療法 , oral delivery , 高分子構造・物性 , 高分子ミセル , イオン液体 , ナノメディシン , 白金錯体

Research theme for competitive and other funds (15)：

2023 - 2026 Development of multidisciplinary immunotherapy utilizing NK cells in combination with PEG-conjugated immune checkpoint antibodies
2023 - 2026 高精度細胞内送達機能を実装する高分子ミセルを用いた革新的がんゲノム編集療法の開発
2022 - 2026 Development of intracellular antibody delivery systems for intracellular immune checkpoint blockade therapy
2023 - 2025 抗体のポリマー修飾に基づく革新的免疫チェックポイント阻害剤の開発
2022 - 2025 経口投与で高分子ミセル型DDSを全身循環に送り込むイオン液体戦略

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Papers (43)：

Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral. Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angewandte Chemie (International ed. in English). 2024. 63. 14. e202317817
Yuki Mochida, Satoshi Uchida. mRNA vaccine designs for optimal adjuvanticity and delivery. RNA Biology. 2024. 21. 1. 1-27
Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, et al. Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery. Small Science. 2024
Pengwen Chen, Wenqian Yang, Yuki Mochida, Shangwei Li, Taehun Hong, Hiroaki Kinoh, Kazunori Kataoka, Horacio Cabral. Selective Intracellular Delivery of Antibodies in Cancer Cells with Nanocarriers Sensing Endo/Lysosomal Enzymatic Activity. Angewandte Chemie - International Edition. 2024
持田祐希, Cabral Horacio, 片岡一則. 還元応答性プロドラッグ型ミセルの免疫賦活作用と大腸がん治療効果. 日本DDS学会学術集会プログラム予稿集. 2023. 39回. 172-172

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MISC (1)：

持田祐希, 河本佑介. DDSの「ちょっとした」技術・知識高速液体クロマトグラフィー(HPLC). Drug Delivery System. 2023. 38. 4. 329-333

Patents (8)：

抗原への結合親和性を低減させた抗体
抗原への結合親和性を低減させた抗体
共重合体、該共重合体の製造方法、およびカルボキシ基またはその塩を有する共重合体の製造方法
PHARMACEUTICAL COMPOSITION FOR TREATMENT AND PREVENTION OF BRAIN TUMOR COMPRISING EPIRUBICIN MICELLE, AND USE THEREOF
ブロックコポリマー、ミセル組成物、及び医薬組成物

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Books (3)：

バイオマテリアル学会誌-生体材料-40巻1号
日本バイオマテリアル学会 2022
未来をつくる仕事図鑑
学研プラス 2021
現代界面コロイド化学の基礎第4版
丸善出版 2018 ISBN:9784621302910

Lectures and oral presentations (14)：

難治がん治療に向けた抗体ポリマー複合体の開発
(日本薬学会第144年会 2024)
PEG修飾免疫チェックポイント阻害剤による強く優しいがん免疫療法
(第72回高分子討論会 2023)
Nanotechnology-based approaches for the development of next-generation cancer drugs
(The 81st Annual Meeting of the Japan Cancer Association 2022)
Elaborate Assembly of Platinum-Complexed Polymeric Micelles for Targeted Chemotherapy
(The 39th International Conference of Photopolymer Science and Technology 2022)
悪性脳腫瘍に集まり免疫力を開放するナノマシン
(第8回COINSシンポジウム 2022)

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Works (1)：

エメラルド
持田祐希 2007 - 現在

Education (5)：

2011 - 2014 The University of Tokyo The Graduate School of Engineering Department of Bioengineering
2009 - 2011 The University of Tokyo The Graduate School of Engineering Department of Bioengineering
2007 - 2009 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology
2005 - 2007 The University of Tokyo College of Arts and Sciences
2002 - 2005 鳥取県立米子東高等学校

Professional career (1)：

Ph.D. (Engineering) (The University of Tokyo)

Work history (9)：

2023/04 - 現在 Tokyo Medical and Dental University Medical Research Institute, Department of Advanced Nanomedical Engineering Junior Associate Professor
2023/04 - 現在 Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine Dupty Principal Research Scientist
2015/06 - 2023/03 Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine Senior Research Scientist
2015/06 - 2018/09 川崎市産業振興財団ナノ医療イノベーションセンター企画・技術支援チーム(兼任)
2016/04 - 2017/03 The University of Tokyo The Graduate School of Engineering, Department of Bioengineering

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Awards (8)：

2023/07 - The Society of Polymer Science, Japan IPC2023 Young Scientist Poster Award
2022/11 - Nano Biomedical Society 17th Nano Biomedical Society Award
2021/06 - 日本DDS学会第37回日本DDS学会学術集会優秀発表賞
2021/01 - Best Presentation Award - 15th COINS General meeting
2019/02 - 東京工業大学手島精一記念研究賞(研究論文賞)

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Association Membership(s) (9)：

Japanese Cancer Association , The Antibody Society of Japan , Japanese Association of Cancer Immunology , The Pharmaceutical Society of Japan , THE JAPANESE SOCIETY FOR BIOMATERIALS , American Chemical Society , Japan Society of Coordination Chemistry , THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM , THE SOCIETY OF POLYMER SCIENCE, JAPAN

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