Research theme for competitive and other funds (9)：
2020 - 2023 Elucidation of molecular basis of biosynthesis with the aim of expanding the diversity of natural products
2019 - 2021 Construction of biosynthetic platform based on metabolism logic of actinomycete and elucidation of the function of unknown biosynthetic gene
Islam A. Abdelhakim, Takayuki Motoyama, Toshihiko Nogawa, Fauze Bin Mahmud, Yushi Futamura, Shunji Takahashi, Hiroyuki Osada. Isolation of new lucilactaene derivatives from P450 monooxygenase and aldehyde dehydrogenase knockout Fusarium sp. RK97-94 strains and their biological activities. The Journal of Antibiotics. 2022. 75. 7. 361-374
Nhu Ngoc Quynh Vo, Yuhta Nomura, Kiyomi Kinugasa, Hiroshi Takagi, Shunji Takahashi. Identification and Characterization of Bifunctional Drimenol Synthases of Marine Bacterial Origin. ACS Chemical Biology. 2022. 17. 5. 1226-1238
Jun-Pil Jang, Mina Jang, Toshihiko Nogawa, Shunji Takahashi, Hiroyuki Osada, Jong Seog Ahn, Sung-Kyun Ko, Jae-Hyuk Jang. RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity. Journal of Microbiology and Biotechnology. 2022. 32. 3. 302-306
Hironori Suemune, Doukan Nishimura, Kenjiro Mizutani, Yusuke Sato, Tomoya Hino, Hiroshi Takagi, Yumi Shiozaki-Sato, Shunji Takahashi, Shingo Nagano. Crystal structures of a 6-dimethylallyltryptophan synthase, IptA: Insights into substrate tolerance and enhancement of prenyltransferase activity. Biochemical and Biophysical Research Communications. 2022. 593. 144-150
Islam A. Abdelhakim, Fauze Bin Mahmud, Takayuki Motoyama, Yushi Futamura, Shunji Takahashi, Hiroyuki Osada. Dihydrolucilactaene, a Potent Antimalarial Compound from Fusarium sp. RK97-94. Journal of Natural Products. 2022. 85. 1. 63-69
