Rchr
J-GLOBAL ID：201801011721921751   Update date: Mar. 20, 2024

Shibata Takuma

シバタ タクマ | Shibata Takuma
Affiliation and department：
東京大学医科学研究所 感染遺伝学分野

About 東京大学医科学研究所 感染遺伝学分野


Job title： 助教
Research field  (1)： Immunology
Research keywords  (7)： TLR8 ,  TLR7 ,  Histiocytosis ,  Autoinflammatory Diseases ,  Autoimmunity ,  Toll Like Receptor ,  Innate Immunity
Research theme for competitive and other funds  (13)：
  • 2023 - 2027 Lysosomes as the starting point of innate immune responses - importance of lysosomal environment -
  • 2022 - 2025 Toll様受容体8に着目したシェーグレン症候群の新たな診断・治療戦略
  • 2021 - 2024 Toll様受容体7シグナルに着目したIgG4関連疾患の新規治療法の開発
  • 2020 - 2023 IgG4関連疾患の免疫学的特異性を基盤とした病因解明と疾患モデルマウスによる検証
  • 2019 - 2022 Elucidating the significance of amplified expression of endogenous retrotransposon in autoimmune/autoinflammatory diseases
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Papers (60)：
  • Ryosuke Hiranuma, Ryota Sato, Kiyoshi Yamaguchi, Satoshi Nakamizo, Kenichi Asano, Takuma Shibata, Ryutaro Fukui, Yoichi Furukawa, Kenji Kabashima, Kensuke Miyake. Aberrant monocytopoiesis drives granuloma development in sarcoidosis. International Immunology. 2023
  • Zhikuan Zhang, Takuma Shibata, Akiko Fujimura, Jiro Kitaura, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature. 2023. 622. 7981. 188-194
  • Takuma Shibata, Ryota Sato, Masato Taoka, Shin-Ichiroh Saitoh, Mayumi Komine, Kiyoshi Yamaguchi, Susumu Goyama, Yuji Motoi, Jiro Kitaura, Kumi Izawa, et al. TLR7/8 stress response drives histiocytosis in SLC29A3 disorders. Journal of Experimental Medicine. 2023. 220. 9
  • Ryota Sato, Kaiwen Liu, Takuma Shibata, Katsuaki Hoshino, Kiyoshi Yamaguchi, Toru Miyazaki, Ryosuke Hiranuma, Ryutaro Fukui, Yuji Motoi, Yuri Fukuda-Ohta, et al. Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhihepatic macrophages. 2023
  • Kentaro Sakaniwa, Akiko Fujimura, Takuma Shibata, Hideki Shigematsu, Toru Ekimoto, Masaki Yamamoto, Mitsunori Ikeguchi, Kensuke Miyake, Umeharu Ohto, Toshiyuki Shimizu. TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nature Communications. 2023. 14. 1. 164-164
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MISC (48)：
  • 坂庭 賢太朗, 柴田 琢磨, 重松 秀樹, 山本 雅貴, 三宅 健介, 大戸 梅治, 清水 敏之. TLR3は効率的なシグナル伝達のためにdsRNA上で多量体を形成する. 日本薬学会年会要旨集. 2022. 142年会. 27C-am05S
  • 木部琴乃, 木部琴乃, 柴田琢磨, 森山雅文, 森山雅文, 三宅健介, 中村誠司. Toll様受容体によって誘導される唾液腺炎病態の解明. 日本シェーグレン症候群学会学術集会プログラム・抄録集. 2021. 29th. 2. 112-113
  • FURUSHO Katsuhiro, SHIBATA Takuma, SATO Ryota, FUKUI Ryutaro, MOTOI Yuji, SAITOH Shin-ichiroh, MIYAKE Kensuke. Cytidine deaminase enables Toll-like receptor 8 activation by cytidine or its analogs. 日本免疫学会総会・学術集会記録(CD-ROM). 2019. 48
  • 劉 洵, 池上 恒雄, 寺門 侑美, 朱 赤, 大杉 友之, 松原 大祐, 藤井 智明, 角田 茂, 久保 幸子, 柴田 琢磨, et al. 新規FBXW7癌特異的変異条件的ノックインマウスの樹立と解析(Establishment and analysis of a novel mouse line carrying a conditional knockin allele of cancer-specific FBXW7 mutation). 日本癌学会総会記事. 2018. 77回. 416-416
  • 石田英子, 大戸梅治, 柴田琢磨, 佐藤亮太, 三宅健介, 清水敏之. 自然免疫受容体TLR9活性化機構の構造生物学的研究. 日本結晶学会年会講演要旨集. 2018. 2018
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Education (3)：
  • 2005 - 2009 University of Tokyo Medical Science Graduate Program
  • 1999 - 2005 Hokkaido University Faculty of Veterinary Medicine
  • 1994 - 1997 Kaijo Senior High School
Work history (4)：
  • 2023/04 - 現在 東京大学医科学研究所 感染遺伝学分野 准教授
  • 2013/01 - 2023/03 The Institute of Medical Science, The University Of Tokyo Division of Infectious Genetics Assistant Professor
  • 2012/10 - 2013/12 The Institute of Medical Science, The University Of Tokyo Division of Infectious Genetics Project Assistant Professor
  • 2009/04 - 2012/09 The Institute of Medical Science, The University Of Tokyo Division of Infectious Genetics postdoctoral fellow
Awards (2)：
  • 2016 - International Immunology International Immunology Outstanding Merit Award Guanosine and its modified derivatives are endogenous ligands for TLR7
  • 2016 - The University of Tokyo Tokyo University Excellent Young Researchers
Association Membership(s) (2)：
THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY
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