Miyara Masatsugu

ミヤラマサツグ | Miyara Masatsugu

Affiliation and department：
Homepage URL (1)： https://kotakelab.hiroshima-u.ac.jp/homepage/

Research field (4)： Pharmaceuticals - health and biochemistry , Pharmacology , Neuropathology , Cell biology

Research keywords (4)： Parkinson's disease , MPTP/MPP<sup>+</sup> , autophagy , lysosome

Research theme for competitive and other funds (7)：

2023 - 2027 発達神経毒性物質と遺伝要因の両者による自閉スペクトラム症発症に関する基礎研究
2022 - 2024 遺伝的素因を考慮した低濃度化学物質のパーキンソン病誘発リスク評価系構築
2020 - 2024 Sensitive evaluation method for neurotoxicity using a novel marker
2020 - 2022 Exploration of therapeutic target molecules for Parkinson's disease by focusing on the regulatory mechanism of lysosomal gene expression
2018 - 2021 p62の細胞質-核間移行に着目した新規パーキンソン病発症メカニズムの解明

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Papers (18)：

Kohei Kawabata, Momoko Sakaue, Shiori Akimoto, Masatsugu Miyara, Yaichiro Kotake, Hiroyuki Nishi. Evaluation of photostability of azelnidipine tablets and structure determination of its photoproducts. Journal of pharmaceutical and biomedical analysis. 2023. 233. 115471-115471
Kohei Kawabata, Haruka Muraoka, Masatsugu Miyara, Yaichiro Kotake, Hiroyuki Nishi. Photodegradation profiling of nitrendipine: evaluation of active pharmaceutical ingredient, tablets and its altered forms. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023
Misaki Hatano, Shunichi Hatamiya, Masatsugu Miyara, Yaichiro Kotake. Tributyltin activates the Keap1-Nrf2 pathway via a macroautophagy-independent reduction in Keap1. The Journal of toxicological sciences. 2023. 48. 3. 161-168
Keishi Ishida, Kazuki Takeda, Yuki Takehara, Tomoki Takabayashi, Masatsugu Miyara, Seigo Sanoh, Hidehiko Kawai, Shigeru Ohta, Yaichiro Kotake. Methylmercury Decreases AMPA Receptor Subunit GluA2 Levels in Cultured Rat Cortical Neurons. Biological & pharmaceutical bulletin. 2023. 46. 2. 292-300
Kanae Umeda-Miyara, Masatsugu Miyara, Seigo Sanoh, Yaichiro Kotake. Trehalose decreases mRNA and protein expressions of c-Jun and JunB in human cervical cancer HeLa cells. The Journal of Biochemistry. 2022. 172. 3. 177-187

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MISC (1)：

宮良政嗣. 環境・衛生メタロチオネインをリソソームに運ぶとTNF毒性が軽減される?. ファルマシア. 2016. 52. 8. 798-798

Lectures and oral presentations (41)：

トリブチルスズ誘発性LC3-II蓄積メカニズムの解明
(第96回日本生化学会大会 2023)
有機スズによる新しいKeap1-Nrf2活性化メカニズム
(メタルバイオサイエンス研究会2023 2023)
トリブチルスズ曝露による巨大なLC3陽性膜小胞の出現
(メタルバイオサイエンス研究会2023 2023)
低濃度パーキンソン病関連化学物質によるグルコース代謝促進とオートファジー機能低下
(フォーラム2023 衛生薬学・環境トキシコロジー 2023)
低濃度パーキンソン病関連化学物質によるオートファジー機能低下とp62核蓄積
(第95回日本生化学会大会 2022)

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Education (3)：

2012 - 2016 Hiroshima University Graduate School of Biomedical Sciences
2010 - 2012 Hiroshima University
2006 - 2010 Prefectural University of Hiroshima Faculty of Life and Environmental Scienses Department of Life Sciences

Professional career (1)：

博士(薬学) (広島大学)

Work history (5)：

2021/04 - 現在 Hiroshima University
2018/04 - 2021/03 日本学術振興会特別研究員-PD(岐阜薬科大学)
2017/04 - 2018/03 Hiroshima University Graduate School of Biomedical Sciences
2016/04 - 2017/03 Hiroshima University
2014/04 - 2016/03 日本学術振興会特別研究員-DC2(広島大学)

Awards (5)：

2019/06 - Pfizer Award Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression
2016/09 - 日本神経化学会優秀発表賞
2014/09 - 日本薬学会環境・衛生部会実行委員長賞
2014/07 - Tanabe Award Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death
2014/03 - 日本薬学会優秀発表賞

Association Membership(s) (4)：

The Japanese Society of Toxicology , The Japanese Society for Neurochemistry , The Molecular Biology Society of Japan , The Pharmaceutical Society of Japan

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