Hirata Eishu

ヒラタエイシュウ | Hirata Eishu

Affiliation and department：
Job title： Associate Professor

Research field (1)： Tumor biology

Research keywords (10)： Brain tumor , Tumor microenvironment , Astrocyte , Microglia , Cancer Metastasis , Drug Resistance , Bioimaging , FRET imaging , Neurosurgery , Migraine

Research theme for competitive and other funds (8)：

2022 - 2025 Development of treatment strategies for cancer brain metastasis targeting metabotropic glutamate receptors
2020 - 2023 がん脳転移微小環境分子基盤の統合的理解と治療への応用
2019 - 2022 Epigenetic analysis and drug development with cell-reprogramming technology in atypical teratoid/rhabdoid tumor
2019 - 2021 アストロサイトを標的としたがん脳転移根治療法の開発
2017 - 2020 Elucidation of the nature of treatment-resistant tumor microenvironment in the central nervous system

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Papers (30)：

Yui Kato, Takuya Uto, Takeru Ishizaki, Daisuke Tanaka, Kojiro Ishibashi, Yuya Matsuda, Issei Onoda, Akiko Kobayashi, Masaharu Hazawa, Richard W Wong, et al. Optimization of Zwitterionic Polymers for Cell Cryopreservation. Macromolecular bioscience. 2024. e2300499
Kojiro Ishibashi, Toshiya Ichinose, Riki Kadokawa, Ryo Mizutani, Sadahiro Iwabuchi, Sumihito Togi, Hiroki Ura, Shoichiro Tange, Keiko Shinjo, Jun Nakayama, et al. Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR. Developmental Cell. 2024
Yui Kato, Yuya Matsuda, Takuya Uto, Daisuke Tanaka, Kojiro Ishibashi, Takeru Ishizaki, Akio Ohta, Akiko Kobayashi, Masaharu Hazawa, Richard W Wong, et al. Cell-compatible isotonic freezing media enabled by thermo-responsive osmolyte-adsorption/exclusion polymer matrices. Communications chemistry. 2023. 6. 1. 260-260
Shoichiro Tange, Tomomi Hirano, Masashi Idogawa, Eishu Hirata, Issei Imoto, Takashi Tokino. MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway. BMC cancer. 2023. 23. 1. 85-85
Takeru Ishizaki, Yasuto Takeuchi, Kojiro Ishibashi, Noriko Gotoh, Eishu Hirata, Kosuke Kuroda. Cryopreservation of tissues by slow-freezing using an emerging zwitterionic cryoprotectant. Scientific Reports. 2023. 13. 1

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MISC (26)：

Kuroda Kosuke, Hirata Eishu. Zwitterionic Liquids as Novel Solvents and Cryoprotectants. Cryobiology and Cryotechnology. 2023. 69. 1. 7-12
Kuroda Kosuke, Hirata Eishu. Novel solvents for life sciences. 2022. 94. 2. 298-301
平田英周. 中枢神経系における治療抵抗性腫瘍微小環境の本態解明-Elucidation of the nature of treatment-resistant tumor microenvironment in the central nervous system-2018年度研究奨励金受領報告. 東京生化学研究会助成研究報告集. 2019. 34. 251-255
平田英周. 脳転移がん細胞の休眠維持と破綻の機構解明. 上原記念生命科学財団研究報告集. 2017. 31. 5p
Interaction between cancer cells and cancer associated fibroblasts. 2016. 67. 2. 146-150

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Patents (6)：

現在非公開(特願2022-098339の優先権主張出願)
現在非公開
現在非公開
脳転移がん抑制剤又は治療剤
固体組成物、液体組成物、及び固体組成物の製造方法

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Books (4)：

がん生物学イラストレイテッド(第2版)第9章 6. 脳腫瘍
羊土社 2019 ISBN:9784758120968
BRAF阻害薬による悪性黒色腫微小環境のparadoxical activationの分子機構
がん分子標的治療 14巻1号遺伝子解析に基づく新しい分子標的治療 2016
がん細胞とがん関連線維芽細胞の相互作用
生体の科学 67巻2号細胞の社会学-細胞間で繰り広げられる協調と競争 2016
イギリスの脳血管障害急性期医療
脳血管障害の急性期マネジメント(監修・橋本信夫、編・清水宏明)文光堂 2014 ISBN:9784830624018

Education (2)：

- 2010 Kyoto University Graduate School of Medicine
- 2002 Kyoto University School of Medicine

Professional career (2)：

M.D. (Kyoto University)
Ph.D. (Kyoto University)

Work history (6)：

2018/09 - 現在 Cancer Research Institute of Kanazawa University Division of Tumor Cell Biology and Bioimaging Associate Professor
2015/08 - 2018/08 Kanazawa Medical University Senior Assistant Professor
2015/04 - 2015/08 Francis-Crick Institute Research Fellow
2011/09 - 2015/03 Cancer Research UK LRI Research Fellow
2010/06 - 2011/08 Kyoto University Graduate School of Biostudies Assistant Professor

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