Research theme for competitive and other funds (11)：
2020 - 2023 Sensing mechanism of PAMPs/DAMPs by innate immune receptors and their contribution to inflammatory diseases
2019 - 2021 Searching for immune checkpoint molecules regulated by an RNA-binding protein HuR
2017 - 2020 Analysis on molecular mechanisms of innate immune regulation via nucleic acids sensors and their roles in development of inflammatory diseases
2017 - 2019 Study on innate immune cells function of mice born from mice receiving virus infection during pregnancy
2015 - 2018 Roles of receptors for damage-associated molecular patterns on neuropathic pain
2015 - 2017 抗癌剤により死滅した癌細胞に対する自然免疫応答の解析
2014 - 2017 Analysis on molecular mechanisms of antiviral innate immune regulation via RNA sensors
2014 - 2016 Role of nucleic acids sensors-induced cell death in shaping adaptive immunity
2011 - 2014 Recognition mechanism of DNA by innate immunity
2008 - 2012 Comprehensive study of innate immunity
2009 - 2010 Role of a new member of the NLR family in pathogen recognition and shaping adaptive immunity
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Papers (152)：
Hachiro Konaka, Yasuhiro Kato, Toru Hirano, Kohei Tsujimoto, JeongHoon Park, Taro Koba, Wataru Aoki, Yusei Matsuzaki, Masayasu Taki, Shohei Koyama, et al. Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome. The EMBO journal. 2023. 42. 20. e112573
Daisuke Ori, Taro Kawai. Pathophysiological functions of self-derived DNA. International reviews of immunology. 2023. 42. 4. 274-286
Takumi Kawasaki, Moe Ikegawa, Kosuke Yunoki, Hifumi Otani, Daisuke Ori, Ken J Ishii, Etsushi Kuroda, Shiki Takamura, Masahiro Kitabatake, Toshihiro Ito, et al. Alveolar macrophages instruct CD8+ T cell expansion by antigen cross-presentation in lung. Cell reports. 2022. 41. 11. 111828-111828
Guang Han Ong, Daisuke Ori, Takumi Kawasaki, Taro Kawai. Inhibition of lipopolysaccharide-induced inflammatory responses by 1'-acetoxychavicol acetate. Genes to cells : devoted to molecular & cellular mechanisms. 2022. 27. 7. 482-492
Shunsuke Yamada, Yuichi Kitai, Takashi Tadokoro, Runa Takahashi, Haruka Shoji, Taiga Maemoto, Marie Ishiura, Ryuta Muromoto, Jun-Ichi Kashiwakura, Ken J Ishii, et al. Identification of RPL15 60S Ribosomal Protein as a Novel Topotecan Target Protein That Correlates with DAMP Secretion and Antitumor Immune Activation. Journal of immunology (Baltimore, Md. : 1950). 2022. 209. 1. 171-179
