2015 - 2017 Development of novel hybrid anti-oxidant based on albumin fusion technology and its therapeutic application on acute radiation syndrome
2015 - 2017 Development of a novel carrier for tumor associated macrophage and its application to cancer immunotherapy
2015 - 2017 Development of new treatment against invasive fungal infection by S-nitrosated protein
2014 - 2017 Novel antioxidant therapy for radiation-induced injuries
2015 - 2016 高分子抗癌剤の腫瘍移行性増大を意図した腫瘍内環境制御ナノ粒子の開発
2015 - 2016 高分子抗癌剤の腫瘍移行性増大を意図した腫瘍内環境制御ナノ粒子の開発
2013 - 2015 S-Nitrosated human serum albumin dimer as novel nano EPR enhancer applied to macromolecular anti-tumor drugs such as micelles and liposomes
2014 - 2015 高分子抗癌剤の治療効果を高める新規EPR増強剤の開発に関する研究
2012 - 2014 S-Nitrosated Alpha-1-acid Glycoprotein Kills Drug-resistant Bacteria and Aids Survival in Sepsis
2011 - 2014 The NO conjugated-albumin nanoparticles for the application to multidisciplinary cancer treatment
2010 - 2012 Development of Nitric oxide traffic protein as a novel drug againstischemic diseases
2009 - 2010 NO付加アルブミンを用いた虚血性疾患治療薬の開発に関する研究
2002 - 2007 新規S-ニトロソ化ヒト血清アルブミンの設計と評価
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Papers (160)：
Takeru Hirai, Mayumi Ikeda-Imafuku, Nanami Tasaka, Victor Tuan Giam Chuang, Ming Xian, Tatsuhiro Ishida, Takaaki Akaike, Yu Ishima. Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides. Advances in Redox Research. 2024. 10
Rie Mukai, Hitomi Okuyama, Miku Uchimura, Kozue Sakao, Miyu Matsuhiro, Mayumi Ikeda-Imafuku, Yu Ishima, Miyu Nishikawa, Shinichi Ikushiro, Akihiro Tai. The binding selectivity of quercetin and its structure-related polyphenols to human serum albumin using a fluorescent dye cocktail for multiplex drug-site mapping. Bioorganic Chemistry. 2024. 107184-107184
Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Victor Tuan Giam Chuang, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida, Yu Ishima. Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways. Pharmaceuticals (Basel, Switzerland). 2024. 17. 1
Taro Shimizu, Amr S Abu Lila, Yuka Kitayama, Ryo Abe, Haruka Takata, Hidenori Ando, Yu Ishima, Tatsuhiro Ishida. Peritoneal B Cells Play a Role in the Production of Anti-polyethylene Glycol (PEG) IgM against Intravenously Injected siRNA-PEGylated Liposome Complexes. Biological & pharmaceutical bulletin. 2024. 47. 2. 469-477
Mohamed Ibrahim, Abdelhameed Mostafa Ramadan Eslam, Elhewan Ali Emam Elsadek Emam Nehal, Emam Abdallah Emam Sherif, Shimizu Taro, ANDO Hidenori, Ishima Yu, Omar Helmy Elgarhy, Hatem A Sarhan, Amal K Hussein, et al. Polyethylene glycol (PEG): The nature, immunogenicity, and role in the hypersensitivity of PEGylated products. Journal of Controlled Release. 2022. Vol.351. 215-230
Matsuo Nana, ANDO Hidenori, Doi Yusuke, Shimizu Taro, Ishima Yu, Ishida Tatsuhiro. The challenge to deliver oxaliplatin (l-OHP) to solid tumors: development of liposomal l-OHP formulations. Chemical & Pharmaceutical Bulletin. 2022. Vol.70. No.5. 351-358
Ishima Yu, Maruyama Toru, Otagiri Masaki, Chuang Victor T G, Ishida Tatsuhiro. The new delivery strategy of albumin carrier utilizing the interaction with albumin receptors. Chemical & Pharmaceutical Bulletin. 2022. Vol.70. No.5. 330-333
高田春風, 安藤英紀, 田島健次, 清水太郎, 異島優, 松島得雄, 草野貴友, 石田竜弘. Preparation of cyclosporine A containing nano-fibrillated bacterial cellulose and its application for the treatment of psoriasis. セルロース学会年次大会講演要旨集. 2022. 29th
川口桂乃, 安藤英紀, 田島健次, 長澤一樹, 清水太郎, 異島優, 松島得雄, 草野貴友, 石田竜弘. Evaluation of the effect of orally administrated nano-fibrillated bacterial cellulose (NFBC) to regulate construction of gut microbiota and prevent obesity. セルロース学会年次大会講演要旨集. 2022. 29th
S-Nitroso Adducts of Albumin Analogs: Characterization, Categorization, and Possible Future Therapeutic Applications
2016
Lectures and oral presentations (285)：
Investigation of the usefulness of human serum albumin nanoparticles as antigen delivery carriers to the spleen
(日本薬剤学会第2回英語セミナー 2023)
Accelerated blood clearance of PEGylated liposomal antitumor agents after topical application of PEG derivatives containing cosmetics in a mouse model
(15th International Symposium on Nanomedicine 2022)
Transfusion of mouse B cells, embedded antigens with hydroxyl PEG-modified liposomes in vitro, induces cellular immune responses in mice
(15th International Symposium on Nanomedicine 2022)
Oral sodium bicarbonate enhances accumulation and antitumor effects of PEGylated liposomal doxorubicin (Doxil®)
(15th International Symposium on Nanomedicine 2022)
Preparation, optimization, and evaluation of anionic DPPG-based LNPs for delivery of peptide antigens
(15th International Symposium on Nanomedicine 2022)
2009/05 - 日本NO学会 日本NO学会 Young Investigator Award最優秀賞 NOと血清アルブミンの生体内反応機構の解明に関する研究
Association Membership(s) (9)：
American Association of Pharmaceutical Scientists
, THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
, 日本NO学会
, THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, 日本毒性学会
, 日本薬物動態学会
, 日本癌学会
, 日本酸化ストレス学会
