Junko Takita

タキタジュンコ | Junko Takita

Affiliation and department：

Research field (2)： Hematology and oncology , Medical biochemistry

Research theme for competitive and other funds (21)：

2021 - 2023 Development of novel therapeutic strategies for pediatric solid tumor based on non-diver gene targeted approaches.
2020 - 2023 Integrated analysis of mechanisms of genetic susceptibility to cancer and clonal evolution in pediatric cancer
2018 - 2020 Elucidation of crosstalk between pediatric cancers and neural development and its application for novel therapeutic strategies
2017 - 2020 Development of novel therapeutic strategies for intractable pediatric cancers based on the multi-omics information
2014 - 2017 Integrative analysis of DNA and RNA structural analysis in refractory leukemia in children

2014 - 2017 Analyses for novel translocation and clonal evolution of pediatric rhabdomyosarcoma using advanced genomics

2014 - 2017 Comprehensive and spationtemporal genetic analyses of clonal evolution of metastatic and recurrent pediatric solid tumors

2014 - 2016 Development of treatment strategy for rhabdomyosarcoma based on control of cancer stem cell proliferation

2014 - 2016 Development of novel therapies for childhood cancers and congenital anomaly syndromes using integrated genetic scanning

2014 - 2016 Assessment of micro residual disease with ultra deep sequencing

2013 - 2016 Development of non-invasive diagnosis and novel therapies for pediatric solid tumor

2012 - 2014 Integrated analysis for pathogenesis of congenital disorders with cancers and developmental delay using innovative genomics

2011 - 2014 Systematic analyses of pathogenesis and cancer stem cell of pediatric solid tumors and development of novel therapeutic strategies

2009 - 2014 Development of the treatment strategy for childhood refractory sarcoma trying to use iPS technology for possible reprogramming of cancer stem cell.

2011 - 2011 ハイスループットゲノム解析を用した小児脳腫瘍における標的チロシンキナーゼの解析

2008 - 2010 Development of disease specific novel therapeutic strategy of pediatric solid tumors based on the molecular pathogenesis

2007 - 2008 Genome-wide analysis of rhabdomyosarcoma and identification ofits prognostic factors

2004 - 2006 マイクロアレイとBACコンティグを用いた神経芽腫発症の分子機構の解析

2004 - 2006 Posttraumatic Stress and Quality of Life in Long Term Childhood Cancer Survivors and Their Families

2002 - 2004 ゲノム整列化チップによる染色体異常の検出と小児がん関連遺伝子の探索

2001 - 2003 Molecular and clinicopathological analysis of tumor suppressor genes in neuroblastoma using the BAC contig spanning chromosome 1p36

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Papers (453)：

Kentaro Akagi, Shiro Baba, Hiroaki Fujita, Yasuhiro Fuseya, Daisuke Yoshinaga, Hirohito Kubota, Eitaro Kume, Fumiaki Fukumura, Koichi Matsuda, Takayuki Tanaka, et al. HOIL-1L deficiency induces cell cycle alteration which causes immaturity of skeletal muscle and cardiomyocytes. Scientific reports. 2024. 14. 1. 8871-8871
Kentaro Watanabe, Keiji Tasaka, Hideto Ogata, Shota Kato, Hiroo Ueno, Katsutsugu Umeda, Tomoya Isobe, Yasuo Kubota, Masahiro Sekiguchi, Shunsuke Kimura, et al. Inhibition of the galactosyltransferase C1GALT1 reduces osteosarcoma cell proliferation by interfering with ERK signaling and cell cycle progression. Cancer Gene Therapy. 2024
Takayuki Miyamoto, Kazushi Izawa, Sho Masui, Atsue Yamazaki, Yuichi Yamasaki, Tadashi Matsubayashi, Mayuka Shiraki, Hidenori Ohnishi, Junko Yasumura, Kawabe Tomohiro, et al. Clinical characteristics of cryopyrin-associated periodic syndrome and long-term real-world efficacy and tolerability of canakinumab in Japan: results of a nationwide survey. Arthritis & rheumatology (Hoboken, N.J.). 2024
Hidemasa Matsuo, Aina Inagami, Yuri Ito, Nana Ito, Shinju Iyoda, Yutarou Harata, Moe Higashitani, Kota Shoji, Miu Tanaka, Mina Noura, et al. Parbendazole as a promising drug for inducing differentiation of acute myeloid leukemia cells with various subtypes. Communications biology. 2024. 7. 1. 123-123
Hisashi Ishida, Shin-Ichi Tsujimoto, Daisuke Hasegawa, Hirotoshi Sakaguchi, Shohei Yamamoto, Masakatsu Yanagimachi, Katsuyoshi Koh, Akihiro Watanabe, Asahito Hama, Yuko Cho, et al. Optimizing transplantation procedures through identification of prognostic factors in second remission for children with acute myeloid leukemia with no prior history of transplant. Haematologica. 2024. 109. 1. 312-317

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MISC (406)：

日衛嶋栄太郎, 川島祐介, 仁平寛士, 井澤和司, 児玉浩子, 乾あやの, 東口素子, 滝田順子, 小原収, 八角高裕. ろ紙血プロテオーム解析を用いたWilson病新規スクリーニング法の可能性. 日本先天代謝異常学会雑誌. 2023. 39
荒川芳輝, 山本悦子, 梅田雄嗣, 峰晴陽平, 宇藤恵, 滝田順子, 溝脇尚志, 宮本享. 小児悪性脳腫瘍の長期成績からみた課題と展望高線量放射線治療が中枢神経原発ジャーミノーマの晩期有害事象増加に関与する. 小児の脳神経. 2022. 47. 2. 171-171
大部聡, 梅田雄嗣, 才田聡, 加藤格, 平松英文, 荒川芳輝, 宇藤恵, 溝脇尚志, 足立壮一, 滝田順子. 頭蓋内germinomaの診断における髄液中胎盤型アルカリフォスファターゼ(PLAP)の有用性. 日本小児血液・がん学会雑誌. 2021. 58. 4. 295-295
土屋邦彦, 宮地充, 細野亜古, 小川淳, 菊田敦, 木下義晶, 野澤久美子, 藤浩, 滝田順子, 大喜多肇, et al. 小児の保健・医療のエビデンスを構築する前向き研究希少疾患横紋筋肉腫に対する臨床研究. 日本小児科学会雑誌. 2021. 125. 2. 164-164
細井創, 宮地充, 土屋邦彦, 細野亜古, 小川淳, 菊田敦, 木下義晶, 野澤久美子, 藤浩, 滝田順子, et al. 我が国における横紋筋肉腫治療多施設共同研究の歴史と今後の展望. 日本小児科学会雑誌. 2021. 125. 2. 191-191

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Lectures and oral presentations (3)：

クリオピリン関連周期熱症候群における体細胞モザイク変異率の推移とシングルセル解析による病態解明
(日本小児リウマチ学会総会・学術集会プログラム・抄録集 2022)
神経芽腫における新規TENM 3-ALK融合遺伝子の解析(Novel ALK fusion in neuroblastoma involving TENM3, a conserved family of transmembrane protein)
(日本癌学会総会記事 2022)
免疫不全と日和見感染症 CDC42 C-term変異体はゴルジ体に集積してpyrinインフラマソームの過剰活性化を引き起こす
(日本臨床免疫学会総会プログラム・抄録集 2021)

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