後藤純

ゴトウジュン | Goto June

所属機関・部署：
職名：准教授
ホームページURL (1件)： http://www.cincinnatichildrens.org/bio/g/june-goto/

研究分野 (3件)：発生生物学 , 分子生物学 , 神経形態学

研究キーワード (3件)：結節性硬化症 , 水頭症 , TSC/mTOR/Akt pathway

競争的資金等の研究課題 (2件)：

2006 - 2009 Investigation of the roles of TSC1/2 in corticogenesis.
2000 - 2006 脳発生におけるFynチロシンキナーゼの機能解析

論文 (24件)：

Phan Q Duy, Stefan C Weise, Claudia Marini, Xiao-Jun Li, Dan Liang, Peter J Dahl, Shaojie Ma, Ana Spajic, Weilai Dong, Jane Juusola, et al. Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus. Nature neuroscience. 2022. 25. 4. 458-473
Eri Iwasawa, Farrah N Brown, Crystal Shula, Fatima Kahn, Sang Hoon Lee, Temugin Berta, David R Ladle, Kenneth Campbell, Francesco T Mangano, June Goto. The Anti-Inflammatory Agent Bindarit Attenuates the Impairment of Neural Development through Suppression of Microglial Activation in a Neonatal Hydrocephalus Mouse Model. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022. 42. 9. 1820-1844
Alicia Bedolla, Aleksandr Taranov, Fucheng Luo, Jiapeng Wang, Flavia Turcato, Elizabeth M Fugate, Nigel H Greig, Diana M Lindquist, Steven A Crone, June Goto, et al. Diphtheria toxin induced but not CSF1R inhibitor mediated microglia ablation model leads to the loss of CSF/ventricular spaces in vivo that is independent of cytokine upregulation. Journal of neuroinflammation. 2022. 19. 1. 3-3
Sanjiv Neupane, June Goto, Steven J Berardinelli, Atsuko Ito, Robert S Haltiwanger, Bernadette C Holdener. Hydrocephalus in mouse B3glct mutants is likely caused by defects in multiple B3GLCT substrates in ependymal cells and subcommissural organ. Glycobiology. 2021. 31. 8. 988-1004
Sheng Chih Jin, Weilai Dong, Adam J Kundishora, Shreyas Panchagnula, Andres Moreno-De-Luca, Charuta G Furey, August A Allocco, Rebecca L Walker, Carol Nelson-Williams, Hannah Smith, et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature medicine. 2020. 26. 11. 1754-1765

MISC (8件)：

Shilpa Prabhakar, Xuan Zhang, June Goto, Miguel Sena-Esteves, Vijaya Ramesh, Roderick Bronson, John W. Chen, Anat O. Stemmer-Rachamimov, David J. Kwiatkowski, Xandra O. Breakefield. AAV-Mediated Gene Replacement Therapy in Mouse Model of Tuberous Sclerosis. MOLECULAR THERAPY. 2015. 23. S78-S78
Alessia Di Nardo, Mary H. Wertz, Jarrett Leech, Emily Greene-Colozzi, June Goto, Dennis Wall, David J. Kwiatkowski, Mustafa Sahin. Neuronal Loss of Tuberous Sclerosis Complex Activity Results in Increased Autophagosome Accumulation Despite mTOR Activation. ANNALS OF NEUROLOGY. 2012. 72. S24-S25
M-C Liang, J. Ma, L. Chen, P. Kozlowski, W. Qin, D. Li, J. Goto, T. Shimamura, D. N. Hayes, M. Meyerson, et al. TSC1 loss synergizes with KRAS activation in lung cancer development in the mouse and confers rapamycin sensitivity. ONCOGENE. 2010. 29. 11. 1588-1597
Kristen Pollizzi, Izabela Malinowska-Kolodziej, Cheryl Doughty, Charles Betz, Jian Ma, June Goto, David J. Kwiatkowski. A hypomorphic allele of Tsc2 highlights the role of TSC1/TSC2 in signaling to AKT and models mild human TSC2 alleles. HUMAN MOLECULAR GENETICS. 2009. 18. 13. 2378-2387
June Goto, Tohru Tezuka, Takanobu Nakazawa, Hiroshi Sagara, Tadashi Yamamoto. Loss of Fyn tyrosine kinase on the C57BL/6 genetic background causes hydrocephalus with defects in oligodendrocyte development. MOLECULAR AND CELLULAR NEUROSCIENCE. 2008. 38. 2. 203-212

学歴 (3件)：

2002 - 2006 東京大学医学系研究科病因・病理学専攻博士課程
2000 - 2002 東京大学医学系研究科医科学修士過程
1996 - 2000 東京学芸大学教育学部生物学科

学位 (1件)：

博士(医学) (東京大学)

経歴 (4件)：

2019/09 - 現在シンシナティ小児病院脳外科准教授
2013/02 - 2019/08 シンシナティ小児病院脳外科講師
2007 - 2012 Brigham and Women's Hospital, Harvard Medical School
2006 - 2007 東京大学医科学研究所癌細胞シグナル研究分野学術振興会特別研究員

所属学会 (2件)：

日本神経科学会 , Society for Neuroscience

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