研究キーワード (10件):
cryo-FIB
, electron microscopy
, cryo-ET
, electron cryo-tomography
, cryo-electron microscopy
, phase plate
, image processing
, cellular structure
, protein structure
, cryo-EM
競争的資金等の研究課題 (2件):
2021 - 2023 Gタンパク質共役受容体超複合体を解明するための新しいクライオ電子顕微鏡法
2019 - 2020 Adaptive optics approach for high-throughput, high-resolution cryo-electron microscopy of biological macromolecules and complexes
論文 (98件):
Wessel A C Burger, Vi Pham, Ziva Vuckovic, Alexander S Powers, Jesse I Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B Tobin, Patrick M Sexton, et al. Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR. Nature communications. 2023. 14. 1. 5440-5440
Jianjun Cao, Matthew J Belousoff, Elliot Gerrard, Radostin Danev, Madeleine M Fletcher, Emma Dal Maso, Herman Schreuder, Katrin Lorenz, Andreas Evers, Garima Tiwari, et al. Structural insight into selectivity of amylin and calcitonin receptor agonists. Nature chemical biology. 2023
Ziva Vuckovic, Jinan Wang, Vi Pham, Jesse I Mobbs, Matthew J Belousoff, Apurba Bhattarai, Wessel A C Burger, Geoff Thompson, Mahmuda Yeasmin, Vindhya Nawaratne, et al. Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics. eLife. 2023. 12
Fabian Eisenstein, Haruaki Yanagisawa, Hiroka Kashihara, Masahide Kikkawa, Sachiko Tsukita, Radostin Danev. Parallel cryo electron tomography on in situ lamellae. Nature methods. 2023. 20. 1. 131-138
Sarah J Piper, Giuseppe Deganutti, Jessica Lu, Peishen Zhao, Yi-Lynn Liang, Yao Lu, Madeleine M Fletcher, Mohammed Akhter Hossain, Arthur Christopoulos, Christopher A Reynolds, et al. Understanding VPAC receptor family peptide binding and selectivity. Nature communications. 2022. 13. 1. 7013-7013
M. Khoshouei, L. Liang, M. Radjainia, W. Baumeister, R. Danev. Phase contrast single particle analysis of small protein complexes at atomic resolutions. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2017. 46. S91-S91
Juergen Plitzko, Julia Mahamid, Benjamin D. Engel, Sahradha Albert, Miroslava Schaffer, Jan Arnold, Yoshiyuki Fukuda, Radostin Danev, Wolfgang Baumeister. Charting Cellular Landscapes in Molecular Detail by in Situ Cryo-Electron Tomography. BIOPHYSICAL JOURNAL. 2016. 110. 3. 2A-2A