高木智

タカキサトシ | Takaki Satoshi

所属機関・部署：
職名：部長
ホームページURL (2件)： http://www.ri.ncgm.go.jp/department/hep/03/abstract.html , http://www.ri.ncgm.go.jp/department/hep/03/index_en.html

研究分野 (1件)：免疫学

研究キーワード (4件)：免疫学 , サイトカイン , リンパ球 , 免疫疾患

競争的資金等の研究課題 (42件)：

2022 - 2025 IL-5/好酸球/脂質代謝軸を介する新規炎症抑制機構の解明と制御
2017 - 2021 肥満に伴う難治性喘息と好酸球体内動態及びその制御
2017 - 2020 疾患関連遺伝子Lnk/Sh2b3を介する病態形成機構と生体防御
2015 - 2018 組織常在性自然IL-5産生細胞の活性化機構と炎症及び線維化制御
2013 - 2016 劇症型細菌感染における好中球造血抑制機構の解明

全件表示

論文 (41件)：

Takashi Sekiya, Shinya Hidano, Satoshi Takaki. Tonic TCR and IL-1β signaling mediate phenotypic alterations of naive CD4+ T cells. Cell Reports. 2024. 43. 3. 113954-113954
Kazunori Matsumura, Taizo Mori, Taeko Dohi, Yuki I Kawamura, Satoshi Takaki. Composition of fatty acids in a high-fat diet affects adipose tissue inflammation by inducing calreticulin on adipocytes and activating group 1 innate lymphoid cells. European journal of immunology. 2024. e2350800
Takashi Sekiya, Shizuko Kagawa, Katsunori Masaki, Koichi Fukunaga, Akihiko Yoshimura, Satoshi Takaki. Regulation of peripheral Th/Treg differentiation and suppression of airway inflammation by Nr4a transcription factors. iScience. 2021. 24. 3. 102166-102166
Hyuk Soon Kim, Min Bum Lee, Dajeong Lee, Keun Young Min, Jimo Koo, Hyun Woo Kim, Young Hwan Park, Su Jeong Kim, Masashi Ikutani, Satoshi Takaki, et al. The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity. Science Advances. 2019. 5. 7
Takashi Sekiya, Satoshi Takaki. RGMB enhances the suppressive activity of the monomeric secreted form of CTLA-4. Scientific Reports. 2019. 9. 6984

MISC (139件)：

Satoshi Takaki. IL-5-producing ILC2s and eosinophils in the development of pulmonary arteriopathy. CYTOKINE. 2017. 100. 64-64
Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong, Sang-Mo Kwon. Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment (vol 7, 158, 2016). STEM CELL RESEARCH & THERAPY. 2017. 8
Makoto Otsu, Nao Suzuki, Satoshi Yamazaki, Tomoyuki Yamaguchi, Motohito Okabe, Hideki Masaki, Satoshi Takaki, Hiromitsu Nakauchi. A possible therapeutic strategy for genetic diseases using hematopoietic stem cells generated from induced pluripotent stem cells. HUMAN GENE THERAPY. 2013. 24. 12. A41-A42
Koji Eto, Hitoshi Takiza, Satoshi Takaki, Hidekazu Nishikii, Atsushi Oda, Hiromitsu Nakauchi. The cytokine signal inhibitor lnk promotes alpha IIb beta 3 integrin outside-in signaling through beta 3 tyrosine phosphorylation in platelets. BLOOD. 2007. 110. 11. 1067A-1067A
Takizawa Hitoshi, Takatsu Kiyoshi, Takaki Satoshi. Transient blocking of Lnk-mediated pathways as a potential approach to promote engrafting ability of hematopoietic progenitor cells. 炎症・再生 : 日本炎症・再生医学会雑誌 = Inflammation and regeneration. 2007. 27. 1. 59-64

書籍 (6件)：

造血およびB細胞産生を制御する抑制性アダプター蛋白質Lnk.
中外医学社「Annual Review 免疫2003」 2002
IL-5レセプターとシグナル伝達.
Annual Review免疫1994 1994
Interleukin-5 receptor.
Eosinophils in Allergy and Inflamation 1994
Interleukin-5 receptor.
Eosinophils in Allergy and Inflamation 1994
Interleukin-5 and its receptor system in the immune system.
Horizon in Cytokine Research, the Third International Mochida Memorial Symposium 1993

学位 (1件)：

博士(医学) (熊本大学)

経歴 (1件)：

2006 - 現在独立行政法人国立国際医療研究センター免疫制御研究部部長

受賞 (1件)：

2002 - 日本炎症・再生医学会奨励賞

所属学会 (10件)：

日本炎症・再生学会 , 日本分子生物学会 , American Association for the Advancement of Science , 日本癌学会 , 日本免疫学会 , The Japanese Society of Inflammation and Regeneration , The Molecular Biology Society of Japan , American Association for the Advancement of Science , The Japanese Cancer Association , The Japnese Society for Immunology

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高木 智

高木智