川内大輔

カワウチダイスケ | Kawauchi Daisuke

所属機関・部署：
職名：教授

研究分野 (3件)：腫瘍生物学 , 発生生物学 , 神経科学一般

研究キーワード (11件)：エピジェネティクス , 脳内微小環境 , 上衣腫 , ゲノム編集 , 癌遺伝子 , 電気穿孔法 , 小児脳腫瘍 , がん幹細胞 , 小脳 , 髄芽腫 , 神経分化

競争的資金等の研究課題 (10件)：

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論文 (47件)：

David R Ghasemi, Konstantin Okonechnikov, Anne Rademacher, Stephan Tirier, Kendra K Maass, Hanna Schumacher, Piyush Joshi, Maxwell P Gold, Julia Sundheimer, Britta Statz, et al. Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage. Nature communications. 2024. 15. 1. 269-269
Konstantin Okonechnikov, Piyush Joshi, Mari Sepp, Kevin Leiss, Ioannis Sarropoulos, Florent Murat, Martin Sill, Pengbo Beck, Kenneth Chun-Ho Chan, Andrey Korshunov, et al. Mapping pediatric brain tumors to their origins in the developing cerebellum. Neuro-oncology. 2023. 25. 10. 1895-1909
Takayoshi Watanabe, Hayato Laurence Mizuno, Jumpei Norimatsu, Takumi Obara, Horacio Cabral, Kouhei Tsumoto, Makoto Nakakido, Daisuke Kawauchi, Yasutaka Anraku. Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting. Polymers. 2023. 15. 7
Yong Ha Youn, Shirui Hou, Chang-Chih Wu, Daisuke Kawauchi, Brent A Orr, Giles W Robinson, David Finkelstein, Makoto M Taketo, Richard J Gilbertson, Martine F Roussel, et al. Primary cilia control translation and the cell cycle in medulloblastoma. Genes & development. 2022. 36. 11-12. 737-751
Weijun Feng, Daisuke Kawauchi, Feng Wan. Editorial: Molecular characteristics and personalized treatment for pediatric brain tumors. Frontiers in oncology. 2022. 12. 1114280-1114280

MISC (36件)：

Melanie Schoof, Michael Spohn, Mario Dorostkar, Sina Neyazi, Michael Bockmayr, Fredrik Swartling, Daisuke Kawauchi, Richard Gilbertson, Jessica Taylor, Yanxin Pei, et al. ARRAY-BASED GLOBAL DNA METHYLATION PROFILING OF MOUSE BRAIN TUMORS ALLOWS COMPARISON TO HUMAN TUMORS. NEURO-ONCOLOGY. 2022. 24. 158-159
Ryo Shiraishi, Gabriele Cancila, Kohei Kumegawa, Patricia da Silva, Owen Chapman, Wang Wanchen, Maki Jami, Mikio Hoshino, Stefan Pfister, Lukas Chavez, et al. DYNAMIC CHROMATIN ALTERATION INDUCES ONCOGENIC HIJACKING BY ESSENTIAL TRANSCRIPTIONAL FACTORS DURING SHH MEDULLOBLASTOMA TUMORIGENESIS. NEURO-ONCOLOGY. 2022. 24. 107-108
Tuyu Zheng, Martin Sill, Roland Imle, Ryo Shiraishi, Wanchen Wang, Alaide Morcavallo, Louis Chesler, Daisuke Kawauchi, Olivier Ayrault, Lutsik Pavlo, et al. DNA METHYLATION-BASED BIOBANK OF MURINE MODELS FOR PEDIATRIC TUMORS. NEURO-ONCOLOGY. 2022. 24. 169-170
Tuyu Zheng, David R. Ghasemi, Konstantin Okonechnikov, Andrey Korshunov, Kendra K. Maass, Martin Sill, Johannes Gojo, Ulrich Schueller, Till Milde, Stephen C. Mack, et al. ZFTA/C11ORF95 FUSIONS DRIVE SUPRATENTORIAL EPENDYMOMA VIA SHARED ONCOGENIC MECHANISMS. NEURO-ONCOLOGY. 2021. 23. 13-14
Ryo Shiraishi, Mana Shimoda, Reo Maruyama, Daisuke Kawauchi. Analysis of epigenetic alteration required for malignant transformation of pre-neoplastic cells in a brain tumor. CANCER SCIENCE. 2021. 112. 849-849

特許 (1件)：

書籍 (1件)：

講演・口頭発表等 (11件)：

エピゲノムの理解を基盤とした髄芽腫の進展機序の解明と新規治療標的分子の同定
(第82回日本がん学会 2023)
Conditional expression and activation of DREADDs reveals novel impact of neuron-tumor communications on brain tumor progression.
(1st Heidelberg Conference on Cancer Neuroscience 2023)
Discovery of Novel Oncogenic Signaling for Pediatric Brain Tumors via Understanding of Human Cancer Genomes
(The 9th US-JAPAN Conference on Oncology 2022)
Discovery and Understanding of Oncogenic Fusion Genes in Ependymoma
(第6回世界連邦脳腫瘍学会 2022)
Epigenetic regulation of SHH subgroup medulloblastoma formation
(第44回日本神経科学学会 2021)

学歴 (2件)：

学位 (1件)：

経歴 (8件)：

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委員歴 (2件)：

受賞 (6件)：

2023/06 - 復旦大学招聘研究者
2020 - Brain Tumour Charity Collaborative Team Award (GN-000690) Targeting Src as a Driver of CNS Grp 4 Medulloblastoma and Glioma
2017 - Brain Tumour Charity Collaborative Team Award (GN-000356) Identification, in-vivo modelling and therapeutic targeting of superenhancer-driven oncogenes in Group 3 medulloblastoma
2011 - St Jude intramural grant: The Anderson fellowship
2009 - 公益財団法人持田記念医学薬学振興財団留学補助金

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所属学会 (4件)：

日本分子生物学会 , 日本癌学会 , 米国癌学会 , 日本神経科学学会

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川内 大輔