成相 直

• 2100 - もやもや病の病態と治療法に関する研究
• 光学計測法の実験的臨床的応用による脳内神経回路網の研究
• 神経受容体計測によるてんかん源性と防御機構の解明
• 機能画像計測を用いた神経損傷とその再生に向けての実験的・臨床的研究
• 悪性脳腫瘍の粒子線治療へのPETの応用
高次脳機能局在計測の脳神経外科臨床への応用
Clinical and experimental application of optical imaging for the investigation of cerebral neuronal circuit
Evaluation of epileptogenecity and protection against it in patients with intractable epilepsy
Clinical Experimental Study of neuronal damage and its regeneration with Functional Neuro imaging
Application of PET imaging of malignant glioma for the development of novel treatment.
Use of Functional Mapping in neurosurgical clinic

• Takashi Sugawara, Taketoshi Maehara, Tadashi Nariai, Masaru Aoyagi, Kikvo Ohno. Independent predictors of shunt-dependent normal pressure hydrocephalus after aneurysmal subarachnoid hemorrhage. Journal of Neurosurgical Sciences. 2016. 60. 2. 154-158
• Masaaki Yamamoto, Takuya Kawabe, Yoshinori Higuchi, Yasunori Sato, Tadashi Nariai, Shinya Watanabe, Bierta E. Barfod, Hidetoshi Kasuya. Validity of Prognostic Grading Indices for Brain Metastasis Patients Undergoing Repeat Radiosurgery. WORLD NEUROSURGERY. 2014. 82. 6. 1242-1249
• Masaaki Yamamoto, Takuya Kawabe, Yasunori Sato, Yoshinori Higuchi, Tadashi Nariai, Shinya Watanabe, Hidetoshi Kasuya. Stereotactic radiosurgery for patients with multiple brain metastases: a case-matched study comparing treatment results for patients with 2-9 versus 10 or more tumors. JOURNAL OF NEUROSURGERY. 2014. 121. 16-25
• Toshiya Momose, Tadashi Nariai, Takuya Kawabe, Motoki Inaji, Yoji Tanaka, Shinya Watanabe, Taketoshi Maehara, Keiichi Oda, Kenji Ishii, Kiichi Ishiwata, et al. Clinical Benefit of C-11 Methionine PET Imaging as a Planning Modality for Radiosurgery of Previously Irradiated Recurrent Brain Metastases. CLINICAL NUCLEAR MEDICINE. 2014. 39. 11. 939-943
• Mikio Hiura, Tadashi Nariai, Kenji Ishii, Muneyuki Sakata, Keiichi Oda, Jun Toyohara, Kiichi Ishiwata. Changes in cerebral blood flow during steady-state cycling exercise: a study using oxygen-15-labeled water with PET. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2014. 34. 3. 389-396

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• Chihiro Hosoda, Tadashi Nariai, Kiichi Ishiwata, Kenji Ishii, Yoshiharu Matsushima, Kikuo Ohno. Correlation between focal brain metabolism and higher brain function in patients with Moyamoya disease. INTERNATIONAL JOURNAL OF STROKE. 2010. 5. 5. 367-373
• Iwae Yu, Motoki Inaji, Jun Maeda, Takashi Okauchi, Tadashi Nariai, Kikuo Ohno, Makoto Higuchi, Tetsuya Suhara. Glial Cell-Mediated Deterioration and Repair of the Nervous System after Traumatic Brain Injury in a Rat Model as Assessed by Positron Emission Tomography. JOURNAL OF NEUROTRAUMA. 2010. 27. 8. 1463-1475
• Kaoru Tamura, Masaru Aoyagi, Hiroaki Wakimoto, Noboru Ando, Tadashi Nariai, Masaaki Yamamoto, Kikuo Ohno. Accumulation of CD 133-positive glioma cells after high-dose irradiation by Gamma Knife surgery plus external beam radiation Clinical article. JOURNAL OF NEUROSURGERY. 2010. 113. 2. 310-318
• Tadashi Nariai, Kiichi Ishiwata, Yuichi Kimura, Motoki Inaji, Toshiya Momose, Tetsuya Yamamoto, Akira Matsumura, Kenji Ishii, Kikuo Ohno. PET pharmacokinetic analysis to estimate boron concentration in tumor and brain as a guide to plan BNCT for malignant cerebral glioma. APPLIED RADIATION AND ISOTOPES. 2009. 67. 7-8. S348-S350
• Takeko Nojiri, Tadashi Nariai, Masaru Aoyagi, Michio Senda, Kenji Ishii, Kiichi Ishiwata, Kikuo Ohno. Contributions of biological tumor parameters to the incorporation rate of l-[methyl-C-11] methionine into astrocytomas and oligodendrogliomas. JOURNAL OF NEURO-ONCOLOGY. 2009. 93. 2. 233-241

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• 前頭葉・頭頂葉の脳機能イメージング
  片山容一, 富永悌二, 斉藤延人, editors. ビジュアル脳神経外科Anatomy & Surgical Approach 1 前頭葉・頭頂葉. 東京: メジカルビュー社 2010
• Positron Emission Tomography in Moyamoya Disease
  Cho B-K, Tominaga T, editors. Moyamoya Disease Update. Tokyo: Springer 2010
• Whole-body tumor imaging: [O-11C]methyl-L-tyrosine/positron emission tomography. .
  In: Hayat M, editor. Cancer Imaging: Instrument and Application. Amsterdam: Elsevier p. 175-9. 2008
• PET Multitracer Studyの脳神経疾患の臨床と研究への応用. In: 柳澤信夫, 篠原幸人, 岩田誠, 清水輝夫, 寺本明, editors. Annual Review 神経2006
  中外医学社 2006
• Testing for cerebral blood flow reserve for chronic ischemic diseases : comparison of Data obtained with Xe-CT/CBF Acetazolamide challenge test and positron emission tomography.
  In:Tomonaga M,Tanaka A,Yonas H, ed. Quantiative cerebral blood flow measurements using stable xenon/CT: clinical application. Armonk, NY:Futura Pubishing Company, Inc., 1995

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• - 1984 東京医科歯科大学 医学部 医学科
• - 1984 東京医科歯科大学

• 医学博士
• MD

• 2013/03 - 現在 東京医科歯科大学大学院医歯学総合研究科 脳神経機能外科学分野 准教授
• 2002 - 現在 Visiting Scientist, Brain Imaging Project, National Institute of Radiological Science
• 1995 - 現在 東京都健康長寿医療センター研究所客員研究員
• 1995 - 現在 Visiting Scientist, Positron Medical Center, Tokyo Metropolitan Institute of Gerontology,
• 1990 - 現在 Assistant Professor, Department of Neurosurgery, Tokyo Medical and Dental University
2001/04 - 2013/02 東京医科歯科大学脳神経外科講師
1990 - 2001 東京医科歯科大学脳神経外科助手
1988 - 1990 米国国立衛生研究所客員研究員
1988 - 1990 Visiting Fellow, NIA, NIH, USA

• 1991 - 現在 日本脳神経外科学会 評議員、代議員、総務委員
• - 現在 日本神経放射線学会 運営委員
• - 現在 日本脳卒中学会 代議員
• - 現在 Congress of Neurological Surgeons International Vista Member
• - 現在 American Association of Neurological Surgeons (AANS) International Member
北米神経科学会(Society for Nevroscience) Member
国際脳循環代謝学会(International Society for Cerebral blood flow and metabolism) Active Member
日本神経外傷学会 学術評議員

• 1999 - 第13回 お茶の水会医科同窓会研究奨励賞
• 1999 - 第5回 日本脳神経外科学会奨励賞
• 1998 - 第36回日本核医学会賞

国際ヒト脳マッピング学会(Organisation for Human Brain Mapping) ,  北米神経科学会(Society for Nevroscience) ,  国際脳循環代謝学会(International Society for Cerebral blood flow and metabolism) ,  日本核医学会 ,  日本小児神経学会 ,  日本神経放射線学会 ,  日本神経外傷学会 ,  日本脳卒中学会 ,  Congress of Neurological Surgeons ,  American Association of Neurological Surgeons (AANS) ,  日本脳神経外科コングレス ,  日本脳神経外科学会