大脇敏之

Owaki Toshiyuki

競争的資金等の研究課題 (6件)：

2022 - 2025 ヒト歯髄幹細胞培養上清による炎症性腸疾患の腸管上皮機能も修復する新規治療法の開発
2018 - 2021 IL-27を介したヒト間葉系幹細胞の肺線維化抑制機構の究明と治療への応用
2017 - 2020 抑制性サイトカインIL-27とIL-35による間葉系幹細胞の治療効果の増強
2014 - 2018 生体センサーを用いたペルソナの識別の可能性に関する研究
2007 - 2012 接着分子をターゲットとした治療薬の創製

全件表示

論文 (23件)：

Yuma Furusaka, Shinya Inoue, Izuru Mizoguchi, Hideaki Hasegawa, Yasuhiro Katahira, Aruma Watanabe, Eri Sakamoto, Ami Sekine, Satomi Miyakawa, Tomohiro Umezu, et al. Potent antitumor effects of the conditioned medium of bone marrow-derived mesenchymal stem cells via IGFBP -4. Cancer Science. 2023
Yoshiyuki Kasai, Ryo Takagi, Shinichiro Kobayashi, Toshiyuki Owaki, Naoyuki Yamaguchi, Hiroko Fukuda, Yusuke Sakai, Yoshinori Sumita, Nobuo Kanai, Hajime Isomoto, et al. A stable protocol for the fabrication of transplantable human oral mucosal epithelial cell sheets for clinical application. REGENERATIVE THERAPY. 2020. 14. 87-94
Ayako Nishimura, Ryota Nakajima, Ryo Takagi, Guangbin Zhou, Daisuke Suzuki, Masaharu Kiyama, Takayuki Nozaki, Toshiyuki Owaki, Tomomi Takahara, Shigeru Nagai, et al. Fabrication of tissue-engineered cell sheets by automated cell culture equipment. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2019. 13. 12. 2246-2255
Yukino Chiba, Izuru Mizoguchi, Hideaki Hasegawa, Mio Ohashi, Naoko Orii, Taro Nagai, Miyaka Sugahara, Yasunori Miyamoto, Mingli Xu, Toshiyuki Owaki, et al. Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases. CELLULAR AND MOLECULAR LIFE SCIENCES. 2018. 75. 8. 1363-1376
Yukino Chiba, Izuru Mizoguchi, Junichi Furusawa, Hideaki Hasegawa, Mio Ohashi, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto. Interleukin-27 Exerts Its Antitumor Effects by Promoting Differentiation of Hematopoietic Stem Cells to M1 Macrophages. CANCER RESEARCH. 2018. 78. 1. 182-194

MISC (94件)：

大脇敏之, 溝口出, 長谷川英哲, 折井直子, 善本隆之. ヒト臍帯血由来間葉系幹細胞による免疫調節とIL-27の関与. 東京医科大学雑誌. 2018. 76. 3. 287-287
善本隆之, 大橋美緒, 長谷川英哲, 折井直子, 徐明利, 大脇敏之, 溝口出. 感作性代替法の現状と展望新しい3次元共培養系を用いた呼吸器感作性代替法の開発. The Journal of Toxicological Sciences. 2018. 43. Suppl. S169-S169
Naoko Orii, Izuru Mizoguchi, Yukino Chiba, Hideaki Hasegawa, Mio Ohashi, Mingli Xu, Taro Nagai, Nakaba Ochiai, Yuki Mochizuki, Toshiyuki Owaki, et al. Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors. OncoImmunology. 2018. 7. 5
大脇敏之, 大脇敏之, 菅原京加, 落合央, 落合央, 溝口出, 千葉佑規乃, 長谷川英哲, 折井直子, 宮本泰則, et al. ヒト間葉系幹細胞による免疫調節とIL-27の関係性. 日本再生医療学会総会(Web). 2018. 17th
Izuru Mizoguchi, Yukino Chiba, Hideaki Hasegawa, Mio Ohashi, Mingli Xu, Toshiyuki Owaki, Takayuki Yoshimoto. A Novel Role for Epstein-Barr Virus-Induced Gene 3 as An Intracellular Molecule That Enhances IL-23 Receptor Expression by Binding to Calnexin and IL-23 Receptor. CYTOKINE. 2017. 100. 48-49

講演・口頭発表等 (81件)：

Chemosensitization of Malignant Tumor Cells to Anticancer Drugs through β1-integrin Activation
(8th Pan-Pacific Connective Tissue Societies Symposium 2009)
Promotion of PDGF-dependent cell proliferation through β1-integrin activation
(8th Pan-Pacific Connective Tissue Societies Symposium 2009)
Sustained Activation of β1-Integrins induces Proliferative Arrest or Apoptosis in Fibroblasts
(8th Pan-Pacific Connective Tissue Societies Symposium 2009)
オートファジー誘導に基づく結核菌殺滅に関する基礎的研究
(日本薬学会第129年会 2009)
反接着ペプチドによる接着依存性薬剤耐性(CAM-DR)の克服
(日本薬学会第129年会 2009)

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