研究者
J-GLOBAL ID:200901092573853300   更新日: 2024年01月31日

小山 文隆

オヤマ フミタカ | Oyama Fumitaka
所属機関・部署:
職名: 教授
研究分野 (6件): 病態医化学 ,  応用生物化学 ,  遺伝学 ,  生体化学 ,  実験動物学 ,  神経形態学
研究キーワード (12件): ほ乳類キチナーゼ ,  キチン含有生物の動物食糧への利用 ,  酵素の構造と機能 ,  キチン・キトサン ,  アレルギー・喘息 ,  ヒトの疾患に関係する遺伝子 ,  firefly luciferase ,  Enzyme strucutr-function relationship ,  Chitin・chitosan ,  allergy and asthma ,  Alzheimer's disease ,  Disease-related genes
競争的資金等の研究課題 (26件):
  • 2016 - 2019 酸性ほ乳類キチナーゼはマウスとブタの消化器系において糖質分解酵素か?
  • 2009 - 2019 Studies on the structure and function relationships of proteins using the biotechnological methods
  • 2009 - 2019 Application of animal biomass for medical and pharmacological areas
  • 2009 - 2019 Development of novel methods for isolation and characterization of cells and nucleic acids
  • 2005 - 2015 Biochemical and molecular cell biological analysis of human disease-related genes
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論文 (49件):
  • Kazuaki Okawa, Eri Tabata, Yuta Kida, Kyohei Uno, Hidetoshi Suzuki, Minori Kamaya, Peter O. Bauer, Fumitaka Oyama. Irreversible evolutionary loss of chitin-degrading ability in the chitinase-like protein Ym1 under positive selection in rodents. Protein Science. 2023
  • Daisuke Yamanaka, Kento Suzuki, Masahiro Kimura, Fumitaka Oyama, Yoshiyuki Adachi. Functionally modified chitotriosidase catalytic domain for chitin detection based on split-luciferase complementation. Carbohydrate polymers. 2022. 282. 119125-119125
  • Maiko Uehara, Eri Tabata, Mikoto Okuda, Yukari Maruyama, Vaclav Matoska, Peter O. Bauer, Fumitaka Oyama. Robust chitinolytic activity of crab-eating monkey (Macaca fascicularis) acidic chitinase under a broad pH and temperature range. Scientific Reports. 2021. 11. 1
  • Eri Tabata, Akihiro Itoigawa, Takumi Koinuma, Hiroshi Tayama, Akinori Kashimura, Masayoshi Sakaguchi, Vaclav Matoska, Peter O Bauer, Fumitaka Oyama. Noninsect-Based Diet Leads to Structural and Functional Changes of Acidic Chitinase in Carnivora. Molecular Biology and Evolution. 2021
  • Satoshi Wakita, Yasusato Sugahara, Masayuki Nakamura, Syunsuke Kobayashi, Kazuhisa Matsuda, Chinatsu Takasaki, Masahiro Kimura, Yuta Kida, Maiko Uehara, Eri Tabata, et al. Mouse Acidic Chitinase Effectively Degrades Random-Type Chitosan to Chitooligosaccharides of Variable Lengths under Stomach and Lung Tissue pH Conditions. Molecules. 2021. 26. 21. 6706-6706
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MISC (96件):
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書籍 (4件):
  • Update article: Chloroquine myopathy suggests that tau is degraded in lysosomes : implication for the formation of paired helical filaments in Alzheimer’s disease.
    Neurosci. Res. Elsevier 1998
  • Nonneural tau: transient upregulation and subsequent accumulation of big and small tau in chloroquine myopathy.
    In Alzheimer's Disease: Biology, Diagnosis and Therapeutics (ed. by Iqbal et al.) 1997
  • Modified nested PCR for the detection of minor molecular variants.
    Neuroscience Protocols. Elsevier 1996
  • 3'-end labeling of DNA fragments by AMV-reverse transcriptase.
    Nucleic Acids Symposium Series. Oxford University Press 1988
講演・口頭発表等 (65件):
  • Analysis of mammalian chitinase mRNA levels in human and mouse tissues
    (The 2014 Annual Meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry 2014)
  • Cloning and expression in Escherichia coli and functional identification of Caulobacter glucoamylase
    (The 2014 Annual Meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry 2014)
  • Characterization of Protein A-mouse acidic mammalian chitinase-V5-His expressed in periplasmic space of Escherichia coli
    (The 2014 Annual Meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry 2014)
  • Expression in Escherichia coli and characterization of two chitinases from Listeria innocua
    (The 2014 Annual Meeting of Japan Society for Bioscience, Biotechnology and Agrochemistry 2014)
  • Preparation of chitin oligomers by hydrolysis with concentrated hydrochloric acid
    (10th International Conference of the Asian Pacific Chitin Chitosan Symposium 2013)
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Works (1件):
  • Alternative Splicing of fibronectin pre-mRNA in Human Tissues
    1992 - 1992
学歴 (6件):
  • - 1985 東北大学大学院 農学研究科 農芸化学専攻
  • - 1985 東北大学
  • - 1982 東北大学大学院 農学研究科 農芸化学専攻
  • - 1982 東北大学
  • - 1980 茨城大学 農学部 農芸化学科
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学位 (3件):
  • 農学士 (茨城大学)
  • 農学修士 (東北大学)
  • 農学博士 (東北大学)
経歴 (16件):
  • 2015/04 - 現在 工学院大学 先進工学部 生命化学科 教授(生物医化学研究室)
  • 2009 - 現在 Professor, Biotechnology Laboratory, Department of Applied Chemistry, Faculty of Engineering, Kogakuin University
  • 2009 - 2015/03 工学院大学工学部応用化学科・教授 (生命工学研究室)
  • 2009 - 2012 独立行政法人理化学研究所脳科学総合研究センター・客員研究員 (構造神経病理研究チーム)
  • 2009 - 2012 Visiting Research Scientist, Laboratory for Structural Neuropathology, RIKEN Brain Science Institute
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委員歴 (4件):
  • 2014/01 - 2014/12 Japanese Society for Chitin and Chitosan Board of directors
  • 2014/01 - 2014/12 Board of directors, the Japanese Society for Chitin and Chitosan
  • 2011/01 - 2013/12 Japanese Society for Chitin and Chitosan Board member
  • 2011/01 - 2013/12 Board of the Japanese Society for Chitin and Chitosan
所属学会 (5件):
日本農芸化学会 ,  アメリカ人類遺伝学会 ,  日本キチン・キトサン学会 ,  American Society of Human Genetics ,  Japanese Society for Chitin and Chitosan
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