文献

J-GLOBAL ID：201602277943822757   整理番号：16A1332291

BRAF阻害剤で治療されたBRAF V600転移性黒色腫患者の臨床的転帰に対するメラノコルチン-1受容体(MC1R)変異体の有害な効果

Detrimental effects of melanocortin-1 receptor (MC1R) variants on the clinical outcomes of BRAF V600 metastatic melanoma patients treated with BRAF inhibitors

著者 (14件)： Guida Michele (Medical Oncology Department, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Strippoli Sabino (Medical Oncology Department, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Ferretta Anna (Medical Oncology Department, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Ferretta Anna (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy) ,  Bartolomeo Nicola (Department of Biomedical Sciences and Human Oncology, University of Bari, Bari, Italy) ,  Porcelli Letizia (Experimental Pharmacology Laboratory, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Maida Immacolata (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy) ,  Azzariti Amalia (Experimental Pharmacology Laboratory, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Tommasi Stefania (Molecular Genetics Laboratory and Radiology, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Grieco Claudia (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy) ,  Guida Stefania (Dermatology Unit, University of Modena and Reggio Emilia, Modena, Italy) ,  Albano Anna (Medical Oncology Department, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Lorusso Vito (Medical Oncology Department, National Cancer Research Centre ‘Giovanni Paolo II’, Bari, Italy) ,  Guida Gabriella (Department of Basic Medical Sciences, Neurosciences and Sense Organs, University of Bari, Bari, Italy)
資料名： Pigment Cell & Melanoma Research  (Pigment Cell & Melanoma Research)
巻： 29  号： 6  ページ： 679-687  発行年： 2016年11月 
JST資料番号： T0984A  ISSN： 1755-1471  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： メラノコルチン-1受容体(MC1R)は皮膚色素沈着において鍵...

シソーラス用語： *ホルモン受容体 ,...
準シソーラス用語： *メラノコルチン受容体1 ,...

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著者キーワード (4件)： Melanocortin-1 receptor ,  BRAF inhibitors ,  metastatic melanoma ,  predictive biomarkers

分類 (2件)： 細胞膜の受容体  (EF04030C) ,  腫ようの化学・生化学・病理学  (GE02030N)

引用文献 (52件)：

• Abdel-Malek, Z.A., Ruwe, A., Kavanagh-Starner, R., Kadekaro, A.L., Swope, V., Haskell-Luevano, C., Koikov, L., and Knittel, J.J. (2009). alpha-MSH tripeptide analogs activate the melanocortin 1 receptor and reduce UV-induced DNA damage in human melanocytes. Pigment Cell Melanoma Res. 22, 635-644.
• Adzhubei, I.A., Schmidt, S., Peshkin, L., Ramensky, V.E., Gerasimova, A., Bork, P., Kondrashov, A.S., and Sunyaev, S.R. (2010). A method and server for predicting damaging missense mutations. Nat. Methods 7,248-249.
• Bohm, M., Wolff, I., Scholzen, T.E., Robinson, S.J., Healy, E., Luger, T.A., Schwarz, T., and Schwarz, A. (2005). alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage. J. Biol. Chem. 280, 5795-5802.
• Bucheit, A., Chen, G., Siroy, A. et al. (2014). Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations. Clin. Cancer Res. 20, 5527-5536.
• Cao, J., Wan, L., Hacker, E. et al. (2013). MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Mol. Cell 51, 409-422.

タイトルに関連する用語 (10件)： BRAF阻害剤 ,  治療 ,  BRAF ,  転移性黒色腫 ,  患者 ,  臨床 ,  転帰 ,  メラノコルチン ,  受容体 ,  変異体