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J-GLOBAL ID：201702215228169275   整理番号：17A0317159

グループ1及びグループ2インフルエンザAウイルスを中和するワクチン誘導抗体【Powered by NICT】

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

著者 (47件)： Joyce M. Gordon (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Wheatley Adam K. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Thomas Paul V. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Chuang Gwo-Yu (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Soto Cinque (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Bailer Robert T. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Druz Aliaksandr (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Georgiev Ivelin S. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Georgiev Ivelin S. (Department of Pathology, Microbiology, and Immunology and Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA) ,  Georgiev Ivelin S. (Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN 37232, USA) ,  Gillespie Rebecca A. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Kanekiyo Masaru (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Kong Wing-Pui (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Leung Kwanyee (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Narpala Sandeep N. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Prabhakaran Madhu S. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Yang Eun Sung (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Zhang Baoshan (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Zhang Yi (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Asokan Mangaiarkarasi (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Boyington Jeffrey C. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Bylund Tatsiana (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Darko Sam (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Lees Christopher R. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Ransier Amy (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Shen Chen-Hsiang (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Wang Lingshu (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Whittle James R. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Wu Xueling (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Yassine Hadi M. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Santos Celia (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Santos Celia (Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Matsuoka Yumiko (Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Tsybovsky Yaroslav (Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA) ,  Baxa Ulrich (Electron Microscopy Laboratory, Cancer Research Technology Program, Leidos Biomedical Research, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA) ,  Mullikin James C. (NIH Intramural Sequencing Center (NISC), National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA) ,  Subbarao Kanta (Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Douek Daniel C. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Graham Barney S. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Koup Richard A. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Ledgerwood Julie E. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Roederer Mario (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Shapiro Lawrence (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Shapiro Lawrence (Department of Biochemistry & Molecular Biophysics and Department of Systems Biology, Columbia University, New York, NY 10027, USA) ,  Kwong Peter D. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  Mascola John R. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA) ,  McDermott Adrian B. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 166  号： 3  ページ： 609-623  発行年： 2016年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 発散インフルエンザAウイルスを中和できる抗体は普遍的ワクチンの基礎を形成することができた。,H5N1DNA/MIVプライムブーストインフルエンザワクチン試験に登録された被験者から,血球凝集素交差反応性メモリーB細胞を分別し,三抗体クラス,グループ1とグループ2インフルエンザAウイルスの多様なサブタイプを中和の各を同定した。血球凝集素と共結晶構造は,各クラスは血球凝集素幹における重複するエピトープを認識する特徴的な生殖系列遺伝子と収束配列モチーフを利用したことを明らかにした。全六解析対象者は,少なくとも1つの多供与体クラスからの配列を有していた,半被験者多供与体クラス配列は交差反応性B細胞の>40%から回収された先行研究とは。対照的に,これらの多供与体クラス配列は公表されている抗体データセットでは稀であった。発散血球凝集素によるワクチン接種は,広いA型インフルエンザ中和抗体をコードするB細胞の頻度を増加させることができる。は普遍的なインフルエンザA免疫戦略を導くためにメトリックとしてこれらのB細胞の配列特性定量化された有病率を提案した。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： *ワクチン ,  ドナー ,  *インフルエンザ ,  エピトープ ,  *抗体 ,  予防接種 ,  中和抗体 ,  罹患率 ,  血球凝集素
準シソーラス用語： A型インフルエンザ ,  共結晶 ,  サブタイプ ,  メモリーB細胞 ,  交差反応性 ,  被験者 , 【Automatic Indexing@JST】

分類 (2件)： 生物学的機能  (EB03040U) ,  感染症・寄生虫症一般  (GD01010H)

タイトルに関連する用語 (6件)： グループ ,  インフルエンザAウイルス ,  中和 ,  ワクチン ,  誘導 ,  抗体