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J-GLOBAL ID：201702216908789405   整理番号：17A0363090

ALKBH1媒介t RNA脱メチル化翻訳を調節する【Powered by NICT】

ALKBH1-Mediated tRNA Demethylation Regulates Translation

著者 (28件)： Liu Fange (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Liu Fange (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Clark Wesley (Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Luo Guanzheng (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Luo Guanzheng (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Wang Xiaoyun (Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Fu Ye (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Fu Ye (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Wei Jiangbo (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Wei Jiangbo (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Wang Xiao (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Wang Xiao (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Hao Ziyang (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Hao Ziyang (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Dai Qing (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Dai Qing (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Zheng Guanqun (Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Ma Honghui (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Ma Honghui (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Han Dali (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Han Dali (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Evans Molly (Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  Klungland Arne (Department of Microbiology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway) ,  Klungland Arne (Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway) ,  Pan Tao (Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  He Chuan (Department of Chemistry, Department of Biochemistry and Molecular Biology, and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  He Chuan (Howard Hughes Medical Institute, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA) ,  He Chuan (Department of Biochemistry and Molecular Biology and Institute for Biophysical Dynamics, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 167  号： 3  ページ： 816-828.e16  発行年： 2016年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： tRNAは蛋白質合成と細胞シグナル伝達ネットワークの中心成分である。tRNAの一つの顕著な特徴は,その大きく変更された状態,その機能に決定的に影響することができる。ここでは,哺乳類ALKBH1はt RNAデメチラーゼであることを示した。t RNAにおけるN~1-メチルアデノシン(m~1A)の脱メチル化を仲介する。標的t RNAのALKBH1触媒脱メチル化は減衰翻訳開始をもたらし,蛋白質合成におけるtRNAの使用を減少した。このプロセスは動的であり,翻訳に影響するグルコースアベイラビリティに応答した。著者らの結果は,転写後遺伝子発現調節の新しい機構としてのtRNAの可逆的メチル化を明らかにした。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 哺乳類 ,  tRNA ,  メチルトランスフェラーゼ ,  *メチル化 ,  タンパク質合成 ,  触媒 ,  *RNA【核酸】 ,  コドン ,  *脱メチル
準シソーラス用語： RNA修飾 ,  翻訳制御 ,  遺伝子発現調節 ,  翻訳開始 ,  シグナル伝達ネットワーク , 【Automatic Indexing@JST】

著者キーワード (10件)： ALKBH1 ,  tRNAメチル化 ,  t RNA脱メチル化 ,  t RNAデメチラーゼ ,  N~1-メチルアデノシン(m~1A) ,  翻訳開始 ,  翻訳伸長 ,  コドン使用 ,  翻訳調節 ,  動的t RNA修飾

分類 (4件)： 遺伝子発現  (EC02040Q) ,  分子構造  (EB03020Y) ,  細胞構成体一般  (EF03010Z) ,  細胞構成体の機能  (EF03060C)

タイトルに関連する用語 (4件)： RNA ,  脱メチル化 ,  翻訳 ,  調節