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J-GLOBAL ID：201702223278417868   整理番号：17A0363474

工学内皮細胞化心筋と心臓に対するaチップのためのバイオプリンティング3次元ミクロ繊維足場【Powered by NICT】

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

著者 (45件)： Zhang Yu Shrike (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Zhang Yu Shrike (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Zhang Yu Shrike (Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02139, USA) ,  Arneri Andrea (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Arneri Andrea (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Arneri Andrea (Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan 20133, Italy) ,  Bersini Simone (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Bersini Simone (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Bersini Simone (Cell and Tissue Engineering Lab, IRCCS Istituto Ortopedico Galeazzi, Milan 20161, Italy) ,  Shin Su-Ryon (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Shin Su-Ryon (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Shin Su-Ryon (Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02139, USA) ,  Zhu Kai (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Zhu Kai (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Zhu Kai (Department of Cardiac Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China) ,  Goli-Malekabadi Zahra (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Goli-Malekabadi Zahra (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Goli-Malekabadi Zahra (Department of Biomedical Engineering, Amirkabir University of Technology, Tehran 64540, Iran) ,  Aleman Julio (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Aleman Julio (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Colosi Cristina (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Colosi Cristina (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Colosi Cristina (Department of Chemistry, Sapienza Universita di Roma, Rome 00185, Italy) ,  Busignani Fabio (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Busignani Fabio (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Busignani Fabio (Department of Electronics and Telecommunications, Politecnico di Torino, Torino 10129, Italy) ,  Dell’Erba Valeria (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Dell’Erba Valeria (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Dell’Erba Valeria (Department of Biomedical Engineering, Politecnico di Torino, Torino 10129, Italy) ,  Bishop Colin (Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA) ,  Shupe Thomas (Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA) ,  Demarchi Danilo (Department of Electronics and Telecommunications, Politecnico di Torino, Torino 10129, Italy) ,  Moretti Matteo (Cell and Tissue Engineering Lab, IRCCS Istituto Ortopedico Galeazzi, Milan 20161, Italy) ,  Moretti Matteo (Swiss Institute for Regnerative Medicine, Lugano 6900, Switzerland) ,  Moretti Matteo (Cardiocentro Ticino, Lugano 6900, Switzerland) ,  Rasponi Marco (Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milan 20133, Italy) ,  Dokmeci Mehmet Remzi (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Dokmeci Mehmet Remzi (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Dokmeci Mehmet Remzi (Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02139, USA) ,  Atala Anthony (Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA) ,  Khademhosseini Ali (Biomaterials Innovation Research Center, Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA) ,  Khademhosseini Ali (Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA) ,  Khademhosseini Ali (Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, MA 02139, USA) ,  Khademhosseini Ali (Department of Bioindustrial Technologies, College of Animal Bioscience and Technology, Konkuk University, Seoul 143-701, Republic of Korea) ,  Khademhosseini Ali (Department of Physics, King Abdulaziz University, Jeddah 21569, Saudi Arabia)
資料名： Biomaterials  (Biomaterials)
巻： 110  ページ： 45-59  発行年： 2016年 
JST資料番号： C0964B  ISSN： 0142-9612  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 工学心臓組織と臓器モデルは,天然心筋の階層的構造のために大きな課題となっている。血管を統合することの必要性は,追加の複雑性をもたらす,を統合した心血管オルガノイドを形成に適していることが利用可能なアプローチを制限している。本研究では,3Dバイオプリンティングに基づく新しいハイブリッド戦略,内皮化心筋を作製するためを提案した。複合生物インクの使用により可能になったことで,ミクロ繊維ヒドロゲル足場内bioprinted直接内皮細胞は徐々にコンフルエント内皮の層を形成するために極細繊維の周辺に向けて移動した。制御された異方性と共に,この3D内皮層は,心筋細胞を播種し,自然発生的及び同期的収縮の可能な整列心筋を発生させた。さらなる心血管毒性評価のための内皮化心筋に及ぼすチッププラットホームを完成するためにオルガノイド特別に設計したマイクロフルイディクス潅流バイオリアクタに埋め込んだ。最後に著者らは,このような技術は,内皮化ヒト心筋を構築するための人工多能性幹細胞由来ヒト心筋細胞に変換できることを示した。は革新的な3Dバイオプリンティング技術により作製した内皮化オルガノイドの生成のためのこの方法は,再生医療,薬物スクリーニング,そして潜在的に疾患モデリングにおける広範な応用を見出すであろうと信じている。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 再生医療 ,  *極細繊維 ,  *心筋 ,  ヒト ,  心筋細胞 ,  モデリング ,  マイクロフルイディクス ,  ヒドロゲル ,  iPS細胞 ,  *三次元 ,  *内皮 ,  *内皮細胞
準シソーラス用語： 内皮化 ,  オルガノイド ,  *バイオプリンティング , 【Automatic Indexing@JST】

著者キーワード (5件)： バイオプリンティング ,  心臓組織工学 ,  Vascularization ,  心臓に対するaチップ ,  心血管毒性

分類 (4件)： 循環系の基礎医学  (GJ01020K) ,  生体代行装置  (EL04000N) ,  医用素材  (GA05040H) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (8件)： 工学 ,  内皮細胞 ,  心筋 ,  心臓 ,  バイオプリンティング ,  3次元 ,  ミクロ繊維 ,  足場