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J-GLOBAL ID：201702284580463064   整理番号：17A0363007

多様な前駆体レパートリーを持つマウスにおけるHIV中和抗体系統の誘導【Powered by NICT】

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

著者 (55件)： Tian Ming (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Tian Ming (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Cheng Cheng (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Chen Xuejun (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Duan Hongying (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Cheng Hwei-Ling (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Cheng Hwei-Ling (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Dao Mai (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Dao Mai (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Sheng Zizhang (Department of Biochemistry and Molecular Biophysics and Department of Systems Biology, Columbia University, New York, NY 10032, USA) ,  Kimble Michael (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Kimble Michael (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Wang Lingshu (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Lin Sherry (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Lin Sherry (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Schmidt Stephen D. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Du Zhou (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Du Zhou (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Joyce M. Gordon (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Chen Yiwei (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Chen Yiwei (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  DeKosky Brandon J. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Chen Yimin (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Chen Yimin (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Normandin Erica (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Cantor Elizabeth (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Cantor Elizabeth (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Chen Rita E. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Doria-Rose Nicole A. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Zhang Yi (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Shi Wei (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Kong Wing-Pui (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Choe Misook (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Henry Amy R. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Laboune Farida (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Georgiev Ivelin S. (Vanderbilt Vaccine Center, Vanderbilt University, Nashville, TN 37232, USA) ,  Huang Pei-Yi (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Huang Pei-Yi (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  Jain Suvi (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Jain Suvi (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA) ,  McGuire Andrew T. (Fred Hutchinson Cancer Research Center, Seattle, WA 02129, USA) ,  Georgeson Eric (Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Menis Sergey (Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Douek Daniel C. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Schief William R. (Department of Immunology and Microbial Science and IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, CA 92037, USA) ,  Schief William R. (Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, Cambridge, MA 02129, USA) ,  Schief William R. (Harvard University, Cambridge, MA 02129, USA) ,  Stamatatos Leonidas (Fred Hutchinson Cancer Research Center, Seattle, WA 02129, USA) ,  Kwong Peter D. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Shapiro Lawrence (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Shapiro Lawrence (Department of Biochemistry and Molecular Biophysics and Department of Systems Biology, Columbia University, New York, NY 10032, USA) ,  Haynes Barton F. (Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA) ,  Mascola John R. (Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA) ,  Alt Frederick W. (Program in Cellular and Molecular Medicine, Boston Children’s Hospital, Howard Hughes Medical Institute, Boston, MA 02115, USA) ,  Alt Frederick W. (Department of Genetics, Harvard Medical School, Boston, MA 02115, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 166  号： 6  ページ： 1471-1484.e18  発行年： 2016年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 広い反応性の中和抗体(bnAbs)を誘発する免疫原の設計はHIV-1ワクチン開発への主要な障害となっている。潜在的免疫原を評価する一つの方法は,予防接種モデルとしてヒトbnAbsの前駆体を発現するマウスを使用することである。VRC01クラスのbnAbsはIGHV1II免疫グロブリン重鎖から導出し,エンベロープ糖蛋白質gp120のCD4結合部位の標的化を介してHIV-1株の広いスペクトルを中和する。生殖系列ヒトIGHV1II~*02セグメントを可能にする正常なV(D)J組換を受けるに導き,そのために,VRC01関連受容体の高度に多様なレパートリーを発現する末梢B細胞の生成につながることをマウスワクチン接種モデルを記述した。VRC01生殖細胞系列および中間抗体を結合するために設計された修飾gp120糖蛋白質で免疫した連続時,VRC01抗体前駆体軽鎖を発現する,IGHV1II~-A*02再配列マウスは抗体系統をHIV中和にVRC01前駆体抗体の親和性成熟を支援することができる。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： CD4抗原 ,  HIV1 ,  *中和抗体 ,  *抗体 ,  結合部位 ,  *中性化 ,  ターゲティング ,  予防接種 ,  *前駆体 ,  軽鎖 ,  ヒト ,  *HIV【ウイルス】
準シソーラス用語： HIVエンベロープ蛋白質gp120 ,  ワクチン開発 ,  免疫原 , 【Automatic Indexing@JST】

分類 (2件)： 抗原・抗体・補体一般  (ED04010A) ,  ウイルス感染の生理と病原性  (EG04042Y)

タイトルに関連する用語 (6件)： 前駆体 ,  マウス ,  HIV ,  中和抗体 ,  系統 ,  誘導