文献

J-GLOBAL ID：201602252906003595   整理番号：16A0814755

ROS関連炎症性腸疾患に対する新しい治療としてキサンチンオキシダーゼ阻害剤の水溶性PEG抱合体,PEG-AHPPミセル

Water soluble PEG-conjugate of xanthine oxidase inhibitor, PEG-AHPP micelles, as a novel therapeutic for ROS related inflammatory bowel diseases

著者 (19件)： Fang Jun (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Fang Jun (Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Japan) ,  Fang Jun (School of Public Health, Anhui Medical University, 81th Meishan Road, Hefei City, Anhui Province 230032, China) ,  Yin Hongzhuan (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Yin Hongzhuan (Department of General Surgery, Sheng Jing Hospital, China Medical University, Shenyang City, Liaoning Province 110004, China) ,  Liao Long (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Liao Long (Department of Applied Microbial Technology, Faculty of Biotechnology & Life Science, Sojo University, Japan) ,  Qin Haibo (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Qin Haibo (Department of Applied Microbial Technology, Faculty of Biotechnology & Life Science, Sojo University, Japan) ,  Ueda Fumiko (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Ueda Fumiko (Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Japan) ,  Uemura Kyoko (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Uemura Kyoko (Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Japan) ,  Eguchi Kanami (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Eguchi Kanami (Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Japan) ,  Bharate Gahininath Y. (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Bharate Gahininath Y. (Department of Nanoscience and Applied Chemistry, Graduate School of Engineering, Sojo University, Japan) ,  Maeda Hiroshi (DDS Research Institute, Sojo University, Ikeda 4-22-1, Nishi-ku, Kumamoto 860-0082, Japan) ,  Maeda Hiroshi (Laboratory of Microbiology & Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Japan)
資料名： Journal of Controlled Release  (Journal of Controlled Release)
巻： 223  ページ： 188-196  発行年： 2016年02月10日 
JST資料番号： C0308D  ISSN： 0168-3659  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： キサンチンオキシダーゼ(XO)は,活性酸素分子種(ROS)が...

シソーラス用語： *炎症 ,...
準シソーラス用語： *キサンチンオキシダーゼ阻害剤 ,...

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著者キーワード (6件)： Inflammatory bowel disease ,  Reactive oxygen species ,  Inflammation ,  Xanthine oxidase inhibitor ,  AHPP ,  Micelle drug

分類 (4件)： 生物薬剤学(基礎)  (GY01021U) ,  医用素材  (GA05040H) ,  酵素製剤・酵素阻害剤の基礎研究  (GW21010W) ,  消化器の基礎医学  (GH01020E)

物質索引 (1件)： 4-アミノ-6-ヒドロキシ-1H-ピラゾロ[3,4-d]ピリミジン

引用文献 (49件)：

• KJ. Davies, Oxidative stress: the paradox of aerobic life, Biochem. Soc. Symp. 61 (1995) 1-31.
• T. Oda, T. Akaike, T. Hamamoto, F. Suzuki, T. Hirano, H. Maeda, Oxygen radicals in influenza-induced pathogenesis and treatment with pyran polymer-conjugated SOD, Science 244 (1989) 974-976.
• H. Maeda, T. Akaike, Oxygen free radicals as pathogenic molecules in viral diseases, Proc. Soc. Exp. Biol. Med. 198 (1991) 721-727.
• J.M. McCord, The evolution of free radicals and oxidative stress, Am. J. Med. 108 (2000) 652-659.
• B. Halliwell, J.M.C. Gutteridge, Free Radicals in Biology and Medicine, Oxford University Press, NJ, USA, 1999 617-859.

タイトルに関連する用語 (8件)： ROS ,  炎症性腸疾患 ,  治療 ,  キサンチンオキシダーゼ阻害剤 ,  水溶性 ,  PEG ,  抱合体 ,  ミセル