文献

J-GLOBAL ID：201702217412072081   整理番号：17A0084204

中枢神経系原始神経外胚葉脳腫瘍(CNS-PNETs)の分子分類から新しい脳腫瘍の実体が明らかになる

New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs

著者 (120件)： Sturm Dominik (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Sturm Dominik (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Sturm Dominik (Department of Pediatric Oncology, Hematology, & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Orr Brent A. (Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105-3678, USA) ,  Toprak Umut H. (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Toprak Umut H. (Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Hovestadt Volker (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Hovestadt Volker (Division of Molecular Genetics, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Jones David T.W. (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Jones David T.W. (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Capper David (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Capper David (Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Capper David (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Sill Martin (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Sill Martin (Division of Biostatistics, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Buchhalter Ivo (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Buchhalter Ivo (Division of Theoretical Bioinformatics, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Northcott Paul A. (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Northcott Paul A. (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Leis Irina (Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Ryzhova Marina (NN Burdenko Neurosurgical Institute, Moscow 125047, Russia) ,  Koelsche Christian (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Koelsche Christian (Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Koelsche Christian (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Pfaff Elke (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Pfaff Elke (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Pfaff Elke (Department of Pediatric Oncology, Hematology, & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Allen Sariah J. (Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN 38105-3678, USA) ,  Balasubramanian Gnanaprakash (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Balasubramanian Gnanaprakash (Division of Applied Bioinformatics, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Worst Barbara C. (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Worst Barbara C. (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Worst Barbara C. (Department of Pediatric Oncology, Hematology, & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Pajtler Kristian W. (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Pajtler Kristian W. (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Brabetz Sebastian (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Brabetz Sebastian (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Johann Pascal D. (Division of Pediatric Neurooncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Johann Pascal D. (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Johann Pascal D. (Department of Pediatric Oncology, Hematology, & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Sahm Felix (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Sahm Felix (Department of Neuropathology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Sahm Felix (Clinical Cooperation Unit Neuropathology, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany) ,  Reimand Jueri (Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada) ,  Reimand Jueri (Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada) ,  Mackay Alan (Division of Molecular Pathology, the Institute of Cancer Research, London SW7 3RP, UK) ,  Carvalho Diana M. (Division of Molecular Pathology, the Institute of Cancer Research, London SW7 3RP, UK) ,  Remke Marc (Program in Developmental and Stem Cell Biology, Division of Neurosurgery, Arthur and Sonia Labatt Brain Tumour Research Centre, Hospital for Sick Children, University of Toronto, Toronto, ON M4N 1X8, Canada) ,  Phillips Joanna J. (Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158-9001, USA) ,  Phillips Joanna J. (Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94143-0102, USA) ,  Phillips Joanna J. (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA) ,  Perry Arie (Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158-9001, USA) ,  Perry Arie (Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, CA 94143-0102, USA) ,  Perry Arie (Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143-0112, USA) ,  Cowdrey Cynthia (Brain Tumor Research Center, University of California, San Francisco, San Francisco, CA 94158-9001, USA) ,  Drissi Rachid (Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA) ,  Fouladi Maryam (Division of Oncology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA) ,  Giangaspero Felice (Department of Radiological, Oncological and Anatomic-Pathological Sciences, Sapienza University of Rome, 00185 Rome, Italy) ,  Giangaspero Felice (IRCCS Neuromed, 86077 Pozzilli, Molise, Italy) ,  Lastowska Maria (Department of Pathology, Children’s Memorial Health Institute, 04-730 Warsaw, Poland) ,  Grajkowska Wieslawa (Department of Pathology, Children’s Memorial Health Institute, 04-730 Warsaw, Poland) ,  Scheurlen Wolfram (Cnopf’sche Kinderklinik, Nuernberg Children’s Hospital, 90419 Nuernberg, Germany) ,  Pietsch Torsten (Department of Neuropathology, University of Bonn Medical School, 53105 Bonn, Germany) ,  Hagel Christian (Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ,  Gojo Johannes (Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria) ,  Gojo Johannes (Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria) ,  Lotsch Daniela (Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria) ,  Berger Walter (Department of Medicine I, Institute of Cancer Research and Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria) ,  Slavc Irene (Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, 1090 Vienna, Austria) ,  Haberler Christine (Institute of Neurology, Medical University of Vienna, 1097 Vienna, Austria) ,  Jouvet Anne (Neuro-Oncology and Neuro-Inflammation Team, Inserm U1028, CNRS UMR 5292, University Lyon-1, Neuroscience Center, 69000 Lyon, France) ,  Jouvet Anne (Centre de Pathologie et de Neuropathologie Est, Hospices Civils de Lyon, 69003 Lyon, France) ,  Holm Stefan (Department of Women’s and Children’s Health (KBH), Karolinska Institutet, 171 77 Stockholm, Sweden) ,  Hofer Silvia (Department of Oncology, Luzerner Kantonsspital, 6000 Luzern 16, Switzerland) ,  Prinz Marco (Institute of Neuropathology, University of Freiburg, 79106 Freiburg, Germany) ,  Prinz Marco (BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79106 Freiburg, Germany) ,  Keohane Catherine (Department of Pathology, University College Cork and Cork University Hospital Wilton, Cork T12 YN60, Ireland) ,  Fried Iris (Department of Pediatric Hematology and Oncology, Hadassah Medical Center, Jerusalem 91120, Israel) ,  Mawrin Christian (Institute of Neuropathology, University Hospital, Otto-von-Guericke University, 39120 Magdeburg, Germany) ,  Scheie David (Department of Pathology, Copenhagen University Hospital, 2100 Kobenhavn O, Denmark) ,  Mobley Bret C. (Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA) ,  Schniederjan Matthew J. (Department of Pathology and Laboratory Administration, Children’s Healthcare of Atlanta, Atlanta, GA 30322, USA) ,  Santi Mariarita (Department of Pathology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA) ,  Buccoliero Anna M. (Pathology Unit, Anna Meyer Children’s University Hospital, 50141 Florence, Italy) ,  Dahiya Sonika (Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA) ,  Kramm Christof M. (Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Gottingen, 37075 Gottingen, Germany) ,  von Bueren Andre O. (Division of Pediatric Hematology and Oncology, Department of Child and Adolescent Health, University Medical Center Gottingen, 37075 Gottingen, Germany) ,  von Hoff Katja (Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ,  Rutkowski Stefan (Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ,  Herold-Mende Christel (Department of Neurosurgery, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Fruehwald Michael C. (Pediatric Hospital, Klinikum Augsburg, 86156 Augsburg, Germany) ,  Milde Till (German Cancer Consortium (DKTK) Core Center Heidelberg, 69120 Heidelberg, Germany) ,  Milde Till (Department of Pediatric Oncology, Hematology, & Immunology, Heidelberg University Hospital, 69120 Heidelberg, Germany) ,  Milde Till (Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ) Heidelberg, 69120 Heidelberg, Germany) ,  Hasselblatt Martin (Institute of Neuropathology, University Hospital Muenster, 48149 Muenster, Germany) ,  Wesseling Pieter (Department of Pathology, VU University Medical Center Amsterdam, 1008 MB Amsterdam, the Netherlands) ,  Wesseling Pieter (Department of Pathology, Radboud University Nijmegen Medical Center, 6525 GA Nijmegen, the Netherlands) ,  Rossler Jochen (Department of Pediatric Hematology/Oncology, Center of Pediatrics and Adolescent Medicine, University Medical Center Freiburg, 79106 Freiburg, Germany) ,  Schueller Ulrich (Department of Neuropathology, Ludwig-Maximilians-University, 81377 Munich, Germany) ,  Schueller Ulrich (German Cancer Consortium (DKTK) Partner Site Munich, 81377 Munich, Germany) ,  Ebinger Martin (Department of Hematology and Oncology, Children’s University Hospital Tuebingen, 72076 Tuebingen, Germany) ,  Ebinger Martin (German Cancer Consortium (DKTK) Partner Site Tuebingen, 72076 Tuebingen, Germany) ,  Schittenhelm Jens (Department of Neuropathology, Institute of Pathology and Neuropathology, University of Tuebingen, 72076 Tuebingen, Germany) ,  Schittenhelm Jens (German Cancer Consortium (DKTK) Partner Site Tuebingen, 72076 Tuebingen, Germany) ,  Frank Stephan (Department of Neuropathology, Institute of Pathology, Basel University Hospital, 4031 Basel, Switzerland) ,  Grobholz Rainer (Department of Pathology, Medical Center Aarau, 5001 Aarau, Switzerland) ,  Vajtai Istvan (Department of Pathology, University Hospital Bern, 3010 Bern, Switzerland) ,  Hans Volkmar ,  Schneppenheim Reinhard (Department of Pediatric Haematology and Oncology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany) ,  Zitterbart Karel ,  Collins V. Peter ,  Aronica Eleonora ,  Varlet Pascale ,  Puget Stephanie ,  Dufour Christelle ,  Grill Jacques ,  Figarella-Branger Dominique ,  Wolter Marietta ,  Wolter Marietta ,  Schuhmann Martin U.
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 164  号： 5  ページ： 1060-1072  発行年： 2016年02月25日 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 中枢神経系原始神経外胚葉脳腫瘍(CNS-PNETs)は,非常に攻撃的で,ほとんど分化していない胚性腫瘍であり,主に幼児期に発症するが,青年および成人にも発症する。ここで著者らは,施設で診断されたCNS-PNETsのかなりの部分が,他の様々な明確な中枢神経系の腫瘍実体と区別できない分子プロファイルを示し,これらの腫瘍を有する患者の診断および適切な治療を容易にすることを示す。CNS-PNETsの残りの部分から,著者らは,それぞれは再発性の遺伝的変化と独特な組織病理学的および臨床的特徴を伴う4つの新しいCNS腫瘍実体を同定する。“FOXR2活性化を有するCNS神経芽細胞腫(CNS NB-FOXR2)”,“CIC改変を有するCNSユーイング肉腫ファミリー腫瘍(CNS EFT-CIC)”,“MN1改変を有するCNS高悪性度神経上皮腫瘍(CNS HGNET-MN1)”,“BCOR改変を有するCNS高悪性度神経上皮腫瘍(CNS HGNET-BCOR)”と指定されたこれらの新しい分子の実体は,未分化CNS腫瘍の影響を受けた患者のための有意義な臨床試験および治療戦略の開発を可能にする。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.

シソーラス用語： ヒト ,  *神経組織腫瘍 ,  脳腫瘍 ,  遺伝子診断 ,  神経芽腫 ,  分類
準シソーラス用語： *原始神経外胚葉腫瘍 ,  分子プロファイリング

分類 (2件)： 基礎腫よう学一般  (GE02010R) ,  神経系の腫よう  (GN04000V)

タイトルに関連する用語 (5件)： 中枢神経系 ,  神経外胚葉 ,  脳腫瘍 ,  分子 ,  分類