文献

J-GLOBAL ID：201702257288747902   整理番号：17A0124724

膵島自己抗体の不均一性と1型糖尿病患者における膵島不全の進行【Powered by NICT】

The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients

著者 (72件)： Liu Jin (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Bian Lingling (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Ji Li (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Chen Yang (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Chen Heng (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Gu Yong (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Ma Bingqin (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Gu Wei (Department of Endocrinology and Metabolism, Nanjing Children’s Hospital) ,  Xu Xinyu (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Shi Yun (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Wang Jian (Department of Endocrinology and Metabolism, Nanjing General Hospital of Nanjing Military Command) ,  Zhu Dalong (Department of Endocrinology and Metabolism, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School) ,  Sun Zilin (Department of Endocrinology and Metabolism, Zhongda Hospital Southeast University) ,  Ma Jianhua (Department of Endocrinology and Metabolism, Nanjing First Hospital) ,  Jin Hui (Department of Endocrinology and Metabolism, Zhongda Hospital Southeast University) ,  Shi Xing (Department of Endocrinology and Metabolism, Nanjing Children’s Hospital) ,  Miao Heng (Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Nanjing Medical University) ,  Xin Bing (Department of Endocrinology and Metabolism, Nanjing Governmental Hospital) ,  Zhu Yan (Department of Endocrinology and Metabolism, Northern Jiangsu People’s Hospital) ,  Zhang Zhenwen (Department of Endocrinology and Metabolism, Northern Jiangsu People’s Hospital) ,  Bu Ruifang (Department of Endocrinology and Metabolism, Wuxi People’s Hospital) ,  Xu Lan (Department of Endocrinology and Metabolism, Wuxi People’s Hospital) ,  Shi Guangde (Department of Endocrinology and Metabolism, Jiangsu Jiangyin People’s Hospital) ,  Tang Wei (Department of Endocrinology and Metabolism, Jiangsu Jiangyin People’s Hospital) ,  Li Wei (Department of Endocrinology and Metabolism, The Affiliated Hospital of Xuzhou Medical College) ,  Zhou Dongmei (Department of Endocrinology and Metabolism, The Affiliated Hospital of Xuzhou Medical College) ,  Liang Jun (Department of Endocrinology and Metabolism, Xuzhou Central Hospital) ,  Cheng Xingbo (Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University) ,  Shi Bimin (Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University) ,  Dong Jixiang (Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University) ,  Hu Ji (Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University) ,  Fang Chen (Department of Endocrinology and Metabolism, The Second Affiliated Hospital of Soochow University) ,  Zhong Shao (Department of Endocrinology and Metabolism, The First People’s Hospital of Kunshan) ,  Yu Weinan (Department of Endocrinology and Metabolism, Huai’an Second People’s Hospital) ,  Lu Weiping (Department of Endocrinology and Metabolism, Huai’an First People’s Hospital) ,  Wu Chenguang (Department of Endocrinology and Metabolism, The First People’s Hospital of Zhenjiang) ,  Qian Li (Department of Endocrinology and Metabolism, The First People’s Hospital of Zhenjiang) ,  Yu Jiancheng (Department of Endocrinology and Metabolism, Yancheng City No.1 People’s Hospital) ,  Gao Jialin (Department of Endocrinology and Metabolism, Jiangsu Taizhou People’s Hospital) ,  Fei Xiaoqiang (Department of Endocrinology and Metabolism, Jiangsu Taizhou People’s Hospital) ,  Zhang Qingqing (Department of Endocrinology and Metabolism, Jiangsu Taizhou People’s Hospital) ,  Wang Xueqin (Department of Endocrinology and Metabolism, The First People’s Hospital of Nantong) ,  Cui Shiwei (Department of Endocrinology and Metabolism, Affiliated Hospital of Nantong University) ,  Cheng Jinluo (Department of Endocrinology and Metabolism, Changzhou No. 2 People’s Hospital) ,  Xu Ning (Department of Endocrinology and Metabolism, The First People’s Hospital of Lianyungang) ,  Wang Guofeng (Department of Endocrinology and Metabolism, The First People’s Hospital of Lianyungang) ,  Han Guoqing (Department of Endocrinology and Metabolism, Binhai People’s Hospital of Yancheng City) ,  Xu Chunrong (Department of Endocrinology and Metabolism, Xuzhou Tumor Hospital) ,  Xie Yun (Department of Endocrinology and Metabolism, Tianjin Medical University Metabolic Disease Hospital) ,  An Minmin (Department of Endocrinology and Metabolism, Wuhu No.2 People’s Hospital) ,  Zhang Wei (Department of Endocrinology and Metabolism, Wuhu No.2 People’s Hospital) ,  Wang Zhixiao (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Cai Yun (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Fu Qi (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Fu Yu (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Zheng Shuai (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Yang Fan (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Hu Qingfang (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Dai Hao (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Jin Yu (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Zhang Zheng (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Xu Kuanfeng (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Li Yifan (Department of Isotopic Laboratory of Nanjing Medical University) ,  Shen Jie (HLA Laboratory of Jiangsu Province People’s Hospital) ,  Zhou Hongwen (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  He Wei (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Zheng Xuqin (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Han Xiao (Nanjing Medical University) ,  Yu Liping (Barbara Davis Center for Childhood Diabetes, University of Colorado Denver) ,  She Jinxiong (Center for Biotechnology and Genomic Medicine, Medical College of Georgia, GA Regents University) ,  Zhang Mei (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University) ,  Yang Tao (Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University)
資料名： Science China. Life Sciences  (Science China. Life Sciences)
巻： 59  号： 9  ページ： 930-939  発行年： 2016年 
JST資料番号： C2576A  ISSN： 1674-7305  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 中国 (CHN)  言語： 英語 (EN)

抄録/ポイント： 1型糖尿病は多くの面で不均一である。患者は,ランゲルハンス氏島機能のいくつかのレベルと同様に可変数とタイプ特異的自己抗体の存在する1型糖尿病を患っていた。本研究は1型糖尿病の膵島自己抗体および臨床表現型の有病率と不均一性を調べることであった。も中国人1型糖尿病患者における膵島障害とその危険因子のプロセスを議論した。1型糖尿病患者1,291例を本研究に登録した。人口統計学的情報を収集した。mixed-meal負荷試験,ヒト白血球抗原対立遺伝子,ヘモグロビンA1c,脂質,甲状腺機能と膵島自己抗体を含む実験室試験を行った。新たに診断されたT1DM患者(半年より短い持続時間)におけるすい島細胞特異的自己抗体の頻度は中国東部で73%であった。二元ロジスティック回帰分析によると,自己抗体陽性,より長い持続時間およびより低いボディマスインデックスは,ランゲルハンス氏島破壊の危険因子であった。疾患を開発し,グルタミン酸脱炭酸酵素に対する自己抗体は亜鉛輸送体8および膵島抗原2に対する他の二自己抗体と同様に減少した。自己抗体の減少は,攻撃的なβ細胞破壊と正に相関した。自己抗体は他のサブタイプから古典的なT1DMの同定を促進し,膵島破壊の進行を予測することができる。疾患の異なる表現型における自己抗体と臨床症状の明らかな不均一性,1型糖尿病を同定する場合は多くの因子を考慮すべきである。Data from the ScienceChina, LCAS. Translated by JST【Powered by NICT】

シソーラス用語： 対立遺伝子 ,  表現型 ,  *不均一性 ,  ボディマスインデックス ,  HbA1c ,  罹患率 ,  継続時間 ,  負荷試験 ,  *1型糖尿病 ,  *Langerhans島 ,  ヒト白血球抗原 ,  *患者 ,  危険因子 ,  *自己抗体
準シソーラス用語： ロジスティック回帰分析 , 【Automatic Indexing@JST】

著者キーワード (4件)： 自己抗体 ,  heterogeneity ,  島破壊 ,  1型糖尿病

分類 (1件)： 代謝異常・栄養性疾患一般  (GD05010J)

タイトルに関連する用語 (5件)： 膵島 ,  自己抗体 ,  不均一性 ,  1型糖尿病 ,  患者