文献

J-GLOBAL ID：201702264451892884   整理番号：17A0086612

心筋梗塞治療に対するアポトーシス遺伝子サイレンシングおよび血管新生遺伝子発現の同時調節:SHP-1 siRNAおよびVEGF発現pDNAの単一キャリアーデリバリー

Simultaneous regulation of apoptotic gene silencing and angiogenic gene expression for myocardial infarction therapy: Single-carrier delivery of SHP-1 siRNA and VEGF-expressing pDNA

著者 (12件)： Kim Dongkyu (Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Kim Dongkyu (Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul 120-752, South Korea) ,  Ku Sook Hee (Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Kim Hyosuk (Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Kim Hyosuk (KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 136-701, South Korea) ,  Jeong Ji Hoon (Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Jeong Ji Hoon (School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea) ,  Lee Minhyung (Department of Bioengineering, College of Engineering, Hanyang University, Seoul 133-791, South Korea) ,  Kwon Ick Chan (Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea) ,  Kwon Ick Chan (School of Pharmacy, Sungkyunkwan University, Suwon 440-746, South Korea) ,  Choi Donghoon (Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University Health System, Seoul 120-752, South Korea) ,  Kim Sun Hwa (Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 136-791, South Korea)
資料名： Journal of Controlled Release  (Journal of Controlled Release)
巻： 243  ページ： 182-194  発行年： 2016年12月10日 
JST資料番号： C0308D  ISSN： 0168-3659  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 遺伝子治療は,疾患の発生に関わる標的遺伝子の選択的なノックア...

シソーラス用語： *心筋梗塞 ,...
準シソーラス用語： ポリアニオン ,...

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著者キーワード (4件)： SHP-1 siRNA ,  VEGF plasmid DNA ,  Myocardial ischemia-reperfusion injury ,  Deoxycholic acid-modified polyethylenimine

分類 (2件)： 循環系の基礎医学  (GJ01020K) ,  遺伝子操作  (EC02050B)

引用文献 (37件)：

• S. Garg, J. Narula, Y. Chandrashekhar, Apoptosis and heart failure: clinical relevance and therapeutic target, J. Mol. Cell. Cardiol. 38 (2005) 73-79.
• R.S. Whelan, V. Kaplinskiy, R.N. Kitsis, Cell death in the pathogenesis of heart disease: mechanisms and significance, Annu. Rev. Physiol. 72 (2010) 19-44.
• S. Gupta, Molecular signaling in death receptor and mitochondrial pathways of apoptosis (review), Int. J. Oncol. 22 (2003) 15-20.
• S. Yousefi, H.-U. Simon, SHP-1: a regulator of neutrophil apoptosis, Semin. Immunol. 15 (2003) 195-199.
• J. Zhang, A.-K. Somani, S. Watt, G.B. Mills, K.A. Siminovitch, The Src-homology domain 2-bearing protein tyrosine phosphatase-1 inhibits antigen receptor-induced apoptosis of activated peripheral T cells, J. Immunol. 162 (1999) 6359-6367.

タイトルに関連する用語 (14件)： 心筋梗塞 ,  治療 ,  アポトーシス ,  遺伝子サイレンシング ,  血管新生 ,  遺伝子発現 ,  調節 ,  SHP-1 ,  siRNA ,  VEGF ,  発現 ,  pDNA ,  キャリアー ,  デリバリー