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J-GLOBAL ID：201702266252895256   整理番号：17A0317170

ヒト高悪性度漿液性卵巣癌の統合プロテオゲノミクス特性化【Powered by NICT】

Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer

著者 (48件)： Zhang Hui (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Liu Tao (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Zhang Zhen (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Payne Samuel H. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Zhang Bai (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  McDermott Jason E. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Zhou Jian-Ying (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Petyuk Vladislav A. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Chen Li (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Ray Debjit (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Sun Shisheng (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Yang Feng (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Chen Lijun (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Wang Jing (Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA) ,  Shah Punit (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Cha Seong Won (Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA) ,  Aiyetan Paul (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Woo Sunghee (Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA) ,  Tian Yuan (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Gritsenko Marina A. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Clauss Therese R. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Choi Caitlin (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Monroe Matthew E. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Thomas Stefani (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Nie Song (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Wu Chaochao (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Moore Ronald J. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Yu Kun-Hsing (Biomedical Informatics Training Program, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Yu Kun-Hsing (Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Tabb David L. (Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA) ,  Fenyo David (Center for Health Informatics and Bioinformatics and Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA) ,  Bafna Vineet (Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA 92093, USA) ,  Wang Yue (Bradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University, Arlington, VA 22203, USA) ,  Rodriguez Henry (Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Boja Emily S. (Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Hiltke Tara (Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Rivers Robert C. (Office of Cancer Clinical Proteomics Research, National Cancer Institute, Bethesda, MD 20892, USA) ,  Sokoll Lori (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Zhu Heng (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Shih Ie-Ming (Department of Gynecology and Obstetrics, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Cope Leslie (Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Pandey Akhilesh (McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA) ,  Zhang Bing (Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37203, USA) ,  Snyder Michael P. (Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA) ,  Levine Douglas A. (Department of Gynecologic Oncology, Laura and Isaac Perlmutter Cancer Centre, NYU Langone Medical Center, New York, NY 10016, USA) ,  Smith Richard D. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA) ,  Chan Daniel W. (Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA) ,  Rodland Karin D. (Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 166  号： 3  ページ： 755-765  発行年： 2016年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 卵巣癌に関連する分子成分及び機構の詳細な分析を提供するために,著者らは,事前に分析した174卵巣腫瘍の包括的質量分析に基づくプロテオミクス特性化を行った。癌ゲノムアトラス(TCGA)であり,その169は高悪性度漿液性癌(HGSCs)であった。ゲノムデータとプロテオーム測定の統合疾患,異なるコピー数変化はプロテオーム,染色体不安定性に関連する蛋白質,多様なゲノム再配列が収束にするシグナル伝達経路のセット,及び短い全生存と関連する最もものにどのように影響するかなどへの多くの知見が得られた。相同組換欠損に関連した特異的蛋白質アセチル化は治療のための患者の階層化のための潜在的な方法を示唆した。貴重な資源を提供することに加えて,これらの知見は,体細胞ゲノムはHGSCにおける蛋白質と翻訳後修飾レベルと臨床結果の間の癌プロテオームとの関連を駆動するかの見解を提供する。ヌル表示省略Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： コピー数 ,  *卵巣腫瘍 ,  翻訳後修飾 ,  プロテオミクス ,  相同組換 ,  体細胞 ,  *キャラクタリゼーション ,  アセチル化 ,  プロテオーム ,  *ヒト ,  ゲノム
準シソーラス用語： ゲノム再編成 ,  染色体不安定性 ,  漿液性癌 ,  *悪性度 , 【Automatic Indexing@JST】

分類 (2件)： 生物学的機能  (EB03040U) ,  蛋白質・ペプチド一般  (EB03010N)

タイトルに関連する用語 (6件)： ヒト ,  悪性度 ,  漿液性卵巣癌 ,  統合 ,  プロテオゲノミクス ,  特性化