文献

J-GLOBAL ID：201702271405878577   整理番号：17A0518519

GalNAc-T6による過剰なAPP O-グリコシル化により,アミロイドβ蛋白質生成を低減する

Excess APP O-glycosylation by GalNAc-T6 decreases Aβ production

著者 (14件)： AKASAKA-MANYA Keiko (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  KAWAMURA Masaki (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  KAWAMURA Masaki (Tokyo Metropolitan Univ., Tokyo, JPN) ,  TSUMOTO Hiroki (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  SAITO Yuko (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  TACHIDA Yuriko (RIKEN, Saitama, JPN) ,  KITAZUME Shinobu (RIKEN, Saitama, JPN) ,  HATSUTA Hiroyuki (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  MIURA Yuri (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  HISANAGA Shin-ichi (Tokyo Metropolitan Univ., Tokyo, JPN) ,  MURAYAMA Shigeo (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  HASHIMOTO Yasuhiro (Fukushima Medical Univ., Fukushima City, JPN) ,  MANYA Hiroshi (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN) ,  ENDO Tamao (Tokyo Metropolitan Geriatric Hospital and Inst. of Gerontology, Tokyo, JPN)
資料名： Journal of Biochemistry  (Journal of Biochemistry)
巻： 161  号： 1  ページ： 99-111  発行年： 2017年01月 
JST資料番号： W1920A  ISSN： 0021-924X  CODEN： JOBIAO  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： Alzheimer病(AD)に関連するアミロイド前駆体蛋白質...

シソーラス用語： *Alzheimer病 ,...
準シソーラス用語： *アミロイド前駆体蛋白質 ,...

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分類 (3件)： 神経の基礎医学  (GN01020W) ,  酵素一般  (EB09010D) ,  蛋白質・ペプチド一般  (EB03010N)

引用文献 (46件)：

• LaFerla, F.M., Green, K.N., and Oddo, S. (2007). Intracellular amyloid-beta in Alzheimer's disease. Nat. Rev. Neurosci. 8, 499-509
• Selkoe, D.J., and Hardy, J. (2016). The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol. Med. 8, 595-608
• Weidemann, A., Konig, G., Bunke, D., Fischer, P., Salbaum, J.M., Masters, C.L., and Beyreuther, K. (1989). Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein. Cell 57, 115-126
• Tomita, S., Kirino, Y., and Suzuki, T. (1998). Cleavage of Alzheimer's amyloid precursor protein (APP) by secretases occurs after O-glycosylation of APP in the protein secretory pathway. Identification of intracellular compartments in which APP cleavage occurs without using toxic agents that interfere with protein metabolism. J. Biol. Chem. 273, 6277-6284
• Sato, Y., Liu, C., Wojczyk, B.S., Kobata, A., Spitalnik, S.L., and Endo, T. (1999). Study of the sugar chains of recombinant human amyloid precursor protein produced by Chinese hamster ovary cells. Biochim. Biophys. Acta 1472, 344-358

タイトルに関連する用語 (3件)： APP ,  O-グリコシル化 ,  アミロイドβ蛋白質