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J-GLOBAL ID：201702273832731692   整理番号：17A0363008

抑制αβT細胞活性化によるγδT細胞の膵臓発癌を支持する【Powered by NICT】

γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation

著者 (26件)： Daley Donnele (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Daley Donnele (Department of Cell Biology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Zambirinis Constantinos Pantelis (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Zambirinis Constantinos Pantelis (Department of Cell Biology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Seifert Lena (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Seifert Lena (Department of Cell Biology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Akkad Neha (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Mohan Navyatha (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Werba Gregor (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Barilla Rocky (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Torres-Hernandez Alejandro (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Hundeyin Mautin (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Mani Vishnu Raj Kumar (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Avanzi Antonina (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Tippens Daniel (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Narayanan Rajkishen (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Jang Jung-Eun (Department of Biochemistry, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Jang Jung-Eun (Department of Pathology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Newman Elliot (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Pillarisetty Venu Gopal (Department of Surgery, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA) ,  Dustin Michael Loran (Department of Pathology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Dustin Michael Loran (The Kennedy Institute of Rheumatology, University of Oxford, Roosevelt Drive, Headington Oxford OX3 7FY, UK) ,  Bar-Sagi Dafna (Department of Biochemistry, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Hajdu Cristina (Department of Pathology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Miller George (S. Arthur Localio Laboratory, Department of Surgery, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA) ,  Miller George (Department of Cell Biology, New York University School of Medicine, 430 East 29th Street, New York, NY 10016, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 166  号： 6  ページ： 1485-1499.e15  発行年： 2016年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 炎症は膵臓発癌に重要である。は活性化γδT細胞集団,ヒト膵管腺癌(PDA)の腫瘍浸潤T細胞の~40%を構成することを同定した。γδT細胞の動員と活性化は多様なケモカイン信号に依存した。欠失,枯渇,またはγδT細胞動員の阻害は,PDAに対する保護とαβT細胞の浸潤増加,活性化およびTh1分極をもたらした。αβT細胞はPDAの転帰に重要でなかったが,それらはγδT細胞アブレーションによる腫瘍保護の不可欠なメディエーターとなった。PDA浸潤γδT細胞は高レベルの消耗のリガンドを発現し,それによって適応抗腫瘍免疫を無効にした。γδT細胞におけるPD-L1の遮断はCD4~+およびCD8~+T細胞浸潤と免疫原性を増強し,腫瘍保護γδT細胞はPDAにおける免疫抑制チェックポイント配位子の重要な源であることを示唆し誘導した。新しいクロストークを介した癌におけるエフェクターT細胞活性化の中心的調節因子としてのγδT細胞について述べた。Copyright 2017 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【Powered by NICT】

シソーラス用語： 腫瘍免疫 ,  浸潤 ,  *発癌 ,  腫瘍浸潤 ,  Th1細胞 ,  腫瘍 ,  *T細胞 ,  細胞浸潤 ,  ヒト ,  ケモカイン ,  免疫原性
準シソーラス用語： *T細胞活性化 ,  リガンド ,  *γδT細胞 ,  *αβT細胞 , 【Automatic Indexing@JST】

著者キーワード (3件)： 癌 ,  Kras ,  チェックポイント配位子

分類 (1件)： 発癌機序・因子  (GE02020C)

タイトルに関連する用語 (5件)： T細胞活性化 ,  γδT細胞 ,  膵臓 ,  発癌 ,  支持