文献

J-GLOBAL ID：201702278481449168   整理番号：17A0552216

健康な中国人ボランティアの薬物動態に及ぼすUDP-グルクロノシルトランスフェラーゼ(UGT)多形の影響

Effects of UDP-glucuronosyltransferase (UGT) polymorphisms on the pharmacokinetics of febuxostat in healthy Chinese volunteers

著者 (9件)： Lin Meihua (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Liu Jian (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Zhou Huili (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Wu Minglan (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Lv Duo (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Huang Yujie (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Zheng Yunliang (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Shentu Jianzhong (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China) ,  Wu Lihua (Research Center of Clinical Pharmacy, State Key Laboratory for Diagnosis and Treatment of Infectious Disease, First Affiliated Hospital, Zhejiang University, Hangzhou, China)
資料名： Drug Metabolism and Pharmacokinetics (Web)  (Drug Metabolism and Pharmacokinetics (Web))
巻： 32  号： 1  ページ： 77-84  発行年： 2017年02月 
JST資料番号： U0705A  ISSN： 1347-4367  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： フェブキソスタットの薬物動態(PK)は個人によって異なるが,...

シソーラス用語： *薬物動力学 ,...
準シソーラス用語： 健常人 ,...

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著者キーワード (5件)： Febuxostat ,  Pharmacokinetics ,  Polymorphisms ,  UGT1A1 ,  UGT1A3

分類 (3件)： 薬物の物理化学的性質  (GV01060M) ,  酵素製剤・酵素阻害剤の基礎研究  (GW21010W) ,  集団遺伝学  (EC01040J)

物質索引 (1件)： フェブキソスタット

引用文献 (38件)：

• Okamoto K, Eger BT, Nishino T, Kondo S, Pai EF, Nishino T. An extremely potent inhibitor of xanthine oxidoreductase. Crystal structure of the enzymeinhibitor complex and mechanism of inhibition. J Biol Chem 2003;278:1848-55.
• Takano Y, Hase-Aoki K, Horiuchi H, Zhao L, Kasahara Y, Kondo S, et al. Selectivity of febuxostat, a novel non-purine inhibitor of xanthine oxidase/xanthine dehydrogenase. Life Sci 2005;76:1835-47.
• Komoriya K, Hoshide S, Takeda K, Kobayashi H, Kubo J, Tsuchimoto M, et al. Pharmacokinetics and pharmacodynamics of febuxostat (TMX-67), a nonpurine selective inhibitor of xanthine oxidase/xanthine dehydrogenase (NPSIXO) in patients with gout and/or hyperuricemia. Nucleosides Nucleotides Nucleic Acids 2004;23:1119-22.
• Becker MA, Kisicki J, Khosravan R, Wu J, Mulford D, Hunt B, et al. Febuxostat (TMX-67), a novel, non-purine, selective inhibitor of xanthine oxidase, is safe and decreases serum urate in healthy volunteers. Nucleosides Nucleotides Nucleic Acids 2004;23:1111-6.
• Grabowski BA, Khosravan R, Vernillet L, Mulford DJ. Metabolism and excretion of [14C] febuxostat, a novel nonpurine selective inhibitor of xanthine oxidase, in healthy male subjects. J Clin Pharmacol 2011;51:189-201.

タイトルに関連する用語 (6件)： 中国人 ,  ボランティア ,  薬物動態 ,  UDP ,  グルクロノシルトランスフェラーゼ ,  多形