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J-GLOBAL ID:201202236047248869   整理番号:12A1188475

ムスカリン4(M4)受容体の新しく、選択的で、脳浸透性のpositive allosteric modulatorとしてのN-(4-メトオキシ-7-メチルベンゾ[d]チアゾール-2-yl)イソニコチンアミド,ML293の発見

Discovery of N-(4-methoxy-7-methylbenzo[d]thiazol-2-yl)isonicatinamide, ML293, as a novel, selective and brain penetrant positive allosteric modulator of the muscarinic 4 (M4) receptor
著者 (40件):
SALOVICH James M.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
SALOVICH James M.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
SALOVICH James M.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
VINSON Paige N.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
VINSON Paige N.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
VINSON Paige N.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
SHEFFLER Douglas J.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
SHEFFLER Douglas J.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
SHEFFLER Douglas J.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
LAMSAL Atin
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
LAMSAL Atin
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
LAMSAL Atin
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
UTLEY Thomas J.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
UTLEY Thomas J.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
UTLEY Thomas J.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
BLOBAUM Anna L.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
BLOBAUM Anna L.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
BLOBAUM Anna L.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
BRIDGES Thomas M.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
BRIDGES Thomas M.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
BRIDGES Thomas M.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
LE Uyen
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
LE Uyen
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
LE Uyen
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
JONES Carrie K.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
JONES Carrie K.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
JONES Carrie K.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
JONES Carrie K.
(US Dep. of Veterans Affairs, Tennessee Valley Healthcare System, Nashville, TN 37232, USA)
WOOD Michael R.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
WOOD Michael R.
(Dep. of Chemistry, Vanderbilt Univ., Nashville, TN 37232, USA)
WOOD Michael R.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
WOOD Michael R.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
SCOTT DANIELS J.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
SCOTT DANIELS J.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
SCOTT DANIELS J.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
JEFFREY CONN P.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
JEFFREY CONN P.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
JEFFREY CONN P.
(Vanderbilt Specialized Chemistry Center for Probe Dev. (MLPCN), Nashville, TN 37232, USA)
NISWENDER Colleen M.
(Dep. of Pharmacology, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)
NISWENDER Colleen M.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt Univ. Medical Center, Nashville, TN 37232, USA)

資料名:
Bioorganic & Medicinal Chemistry Letters  (Bioorganic & Medicinal Chemistry Letters)

巻: 22  号: 15  ページ: 5084-5088  発行年: 2012年08月01日 
JST資料番号: W0248A  ISSN: 0960-894X  資料種別: 逐次刊行物 (A)
発行国: オランダ (NLD)  言語: 英語 (EN)
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