文献
J-GLOBAL ID:201302212940210943
整理番号:13A1196287
2-{3-[2-(1-イソプロピル-3-メチル-1H-1,2-4-トリアゾール-5-イル)-5,6-ジヒドロベンゾ[f]イミダゾ[1,2-d][1,4]オキサゼピン-9-イル]-1H-ピラゾール-1-イル}-2-メチルプロパナミド(GDC-0032)の発見:高い非結合曝露と頑健なin vivo抗腫瘍活性を有するβ-スペアリングホスホイノシチド3-キナーゼ阻害剤
Discovery of 2-{3-[2-(1-Isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): A β-Sparing Phosphoinositide 3-Kinase Inhibitor with High Unbound Exposure and Robust in Vivo Antitumor Activity
著者 (29件):
NDUBAKU Chudi O.
(Genentech, Inc., California, USA)
,
HEFFRON Timothy P.
(Genentech, Inc., California, USA)
,
STABEN Steven T.
(Genentech, Inc., California, USA)
,
BAUMGARDNER Matthew
(Genentech, Inc., California, USA)
,
BLAQUIERE Nicole
(Genentech, Inc., California, USA)
,
BRADLEY Erin
(Genentech, Inc., California, USA)
,
BULL Richard
(Argenta Discovery, Essex, GBR)
,
DO Steven
(Genentech, Inc., California, USA)
,
DOTSON Jennafer
(Genentech, Inc., California, USA)
,
DUDLEY Danette
(Genentech, Inc., California, USA)
,
EDGAR Kyle A.
(Genentech, Inc., California, USA)
,
FRIEDMAN Lori S.
(Genentech, Inc., California, USA)
,
GOLDSMITH Richard
(Genentech, Inc., California, USA)
,
HEALD Robert A.
(Argenta Discovery, Essex, GBR)
,
KOLESNIKOV Aleksandr
(Genentech, Inc., California, USA)
,
LEE Leslie
(Genentech, Inc., California, USA)
,
LEWIS Cristina
(Genentech, Inc., California, USA)
,
NANNINI Michelle
(Genentech, Inc., California, USA)
,
NONOMIYA Jim
(Genentech, Inc., California, USA)
,
PANG Jodie
(Genentech, Inc., California, USA)
,
PRICE Steve
(Argenta Discovery, Essex, GBR)
,
PRIOR Wei Wei
(Genentech, Inc., California, USA)
,
SALPHATI Laurent
(Genentech, Inc., California, USA)
,
SIDERIS Steve
(Genentech, Inc., California, USA)
,
WALLIN Jeffery J.
(Genentech, Inc., California, USA)
,
WANG Lan
(Genentech, Inc., California, USA)
,
WEI BinQing
(Genentech, Inc., California, USA)
,
SAMPATH Deepak
(Genentech, Inc., California, USA)
,
OLIVERO Alan G.
(Genentech, Inc., California, USA)
資料名:
Journal of Medicinal Chemistry
(Journal of Medicinal Chemistry)
巻:
56
号:
11
ページ:
4597-4610
発行年:
2013年06月13日
JST資料番号:
D0102A
ISSN:
0022-2623
CODEN:
JMCMAR
資料種別:
逐次刊行物 (A)
記事区分:
原著論文
発行国:
アメリカ合衆国 (USA)
言語:
英語 (EN)