文献
J-GLOBAL ID:201702268133956592
整理番号:17A0215904
強力でWT温存的な,T790M含有EGFR変異体の不可逆的阻害剤である1-{(3R,4R)-3-[({5-クロロ-2-[(1-メチル-1H-ピラゾール-4-イル)アミノ]-7H-ピロロ[2,3-d]ピリミジン-4-イル}オキシ)メチル]-4-メトキシピロリジン-1-イル}プロパ-2-エン-1-オン(PF-06459988)の発見
Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants
著者 (51件):
CHENG Hengmiao
(Pfizer Worldwide Res. and Dev., California, USA)
,
NAIR Sajiv K.
(Pfizer Worldwide Res. and Dev., California, USA)
,
MURRAY Brion W.
(Pfizer Worldwide Res. and Dev., California, USA)
,
ALMADEN Chau
(Pfizer Worldwide Res. and Dev., California, USA)
,
BAILEY Simon
(Pfizer Worldwide Res. and Dev., California, USA)
,
BAXI Sangita
(Pfizer Worldwide Res. and Dev., California, USA)
,
BEHENNA Doug
(Pfizer Worldwide Res. and Dev., California, USA)
,
CHO-SCHULTZ Sujin
(Pfizer Worldwide Res. and Dev., California, USA)
,
DALVIE Deepak
(Pfizer Worldwide Res. and Dev., California, USA)
,
DINH Dac M.
(Pfizer Worldwide Res. and Dev., California, USA)
,
EDWARDS Martin P.
(Pfizer Worldwide Res. and Dev., California, USA)
,
FENG Jun Li
(Pfizer Worldwide Res. and Dev., California, USA)
,
FERRE Rose Ann
(Pfizer Worldwide Res. and Dev., California, USA)
,
GAJIWALA Ketan S.
(Pfizer Worldwide Res. and Dev., California, USA)
,
HEMKENS Michelle D.
(Pfizer Worldwide Res. and Dev., California, USA)
,
JACKSON-FISHER Amy
(Pfizer Worldwide Res. and Dev., California, USA)
,
JALAIE Mehran
(Pfizer Worldwide Res. and Dev., California, USA)
,
JOHNSON Ted O.
(Pfizer Worldwide Res. and Dev., California, USA)
,
KANIA Robert S.
(Pfizer Worldwide Res. and Dev., California, USA)
,
KEPHART Susan
(Pfizer Worldwide Res. and Dev., California, USA)
,
LAFONTAINE Jennifer
(Pfizer Worldwide Res. and Dev., California, USA)
,
LUNNEY Beth
(Pfizer Worldwide Res. and Dev., California, USA)
,
LIU Kevin K.-C.
(Pfizer Worldwide Res. and Dev., California, USA)
,
LIU Zhengyu
(Pfizer Worldwide Res. and Dev., California, USA)
,
MATTHEWS Jean
(Pfizer Worldwide Res. and Dev., California, USA)
,
NAGATA Asako
(Pfizer Worldwide Res. and Dev., California, USA)
,
NIESSEN Sherry
(Pfizer Worldwide Res. and Dev., California, USA)
,
ORNELAS Martha A.
(Pfizer Worldwide Res. and Dev., California, USA)
,
ORR Suvi T. M.
(Pfizer Worldwide Res. and Dev., California, USA)
,
PAIRISH Mason
(Pfizer Worldwide Res. and Dev., California, USA)
,
PLANKEN Simon
(Pfizer Worldwide Res. and Dev., California, USA)
,
REN Shijian
(Wuxi AppTec, Shanghai, CHN)
,
RICHTER Daniel
(Pfizer Worldwide Res. and Dev., California, USA)
,
RYAN Kevin
(Pfizer Worldwide Res. and Dev., California, USA)
,
SACH Neal
(Pfizer Worldwide Res. and Dev., California, USA)
,
SHEN Hong
(Pfizer Worldwide Res. and Dev., California, USA)
,
SMEAL Tod
(Pfizer Worldwide Res. and Dev., California, USA)
,
SOLOWIEJ Jim
(Pfizer Worldwide Res. and Dev., California, USA)
,
SUTTON Scott
(Pfizer Worldwide Res. and Dev., California, USA)
,
TRAN Khanh
(Pfizer Worldwide Res. and Dev., California, USA)
,
TSENG Elaine
(Pfizer Worldwide Res. and Dev., California, USA)
,
VERNIER William
(Pfizer Worldwide Res. and Dev., California, USA)
,
WALLS Marlena
(Pfizer Worldwide Res. and Dev., California, USA)
,
WANG Shuiwang
(Wuxi AppTec, Shanghai, CHN)
,
WEINRICH Scott L.
(Pfizer Worldwide Res. and Dev., California, USA)
,
XIN Shuibo
(Wuxi AppTec, Shanghai, CHN)
,
XU Haiwei
(Wuxi AppTec, Shanghai, CHN)
,
YIN Min-Jean
(Pfizer Worldwide Res. and Dev., California, USA)
,
ZIENTEK Michael
(Pfizer Worldwide Res. and Dev., California, USA)
,
ZHOU Ru
(Pfizer Worldwide Res. and Dev., California, USA)
,
KATH John C.
(Pfizer Worldwide Res. and Dev., California, USA)
資料名:
Journal of Medicinal Chemistry
(Journal of Medicinal Chemistry)
巻:
59
号:
5
ページ:
2005-2024
発行年:
2016年03月10日
JST資料番号:
D0102A
ISSN:
0022-2623
CODEN:
JMCMAR
資料種別:
逐次刊行物 (A)
記事区分:
原著論文
発行国:
アメリカ合衆国 (USA)
言語:
英語 (EN)