文献
J-GLOBAL ID:201702274401458061
整理番号:17A0216130
経口チェックポイントキナーゼ1(CHK1)阻害剤の臨床候補を与えるためのマルチパラメータ最適化: (R)-5-((4-モルフォリン-2-イルメチル)アミノ)-5-(トリフルオロメチル)ピリジン-2-イル)アミノ)ピラジン-2-カルボニトリル(CCT245737)
Multiparameter Lead Optimization to Give an Oral Checkpoint Kinase 1 (CHK1) Inhibitor Clinical Candidate: (R)-5-((4-((Morpholin-2-ylmethyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino)pyrazine-2-carbonitrile (CCT245737)
著者 (27件):
OSBORNE James D.
(Inst. of Cancer Res., London, GBR)
,
MATTHEWS Thomas P.
(Inst. of Cancer Res., London, GBR)
,
MCHARDY Tatiana
(Inst. of Cancer Res., London, GBR)
,
PROISY Nicolas
(Inst. of Cancer Res., London, GBR)
,
CHEUNG Kwai-Ming J.
(Inst. of Cancer Res., London, GBR)
,
LAINCHBURY Michael
(Inst. of Cancer Res., London, GBR)
,
BROWN Nathan
(Inst. of Cancer Res., London, GBR)
,
WALTON Michael I.
(Inst. of Cancer Res., London, GBR)
,
EVE Paul D.
(Inst. of Cancer Res., London, GBR)
,
BOXALL Katherine J.
(Inst. of Cancer Res., London, GBR)
,
HAYES Angela
(Inst. of Cancer Res., London, GBR)
,
HENLEY Alan T.
(Inst. of Cancer Res., London, GBR)
,
VALENTI Melanie R.
(Inst. of Cancer Res., London, GBR)
,
DE HAVEN BRANDON Alexis K.
(Inst. of Cancer Res., London, GBR)
,
BOX Gary
(Inst. of Cancer Res., London, GBR)
,
JAMIN Yann
(Inst. of Cancer Res., London, GBR)
,
ROBINSON Simon P.
(Inst. of Cancer Res., London, GBR)
,
WESTWOOD Isaac M.
(Inst. of Cancer Res., London, GBR)
,
VAN MONTFORT Rob L. M.
(Inst. of Cancer Res., London, GBR)
,
LEONARD Philip M.
(Sareum Ltd., Cambridge, GBR)
,
LAMERS Marieke B. A. C.
(Sareum Ltd., Cambridge, GBR)
,
READER John C.
(Sareum Ltd., Cambridge, GBR)
,
AHERNE G. Wynne
(Inst. of Cancer Res., London, GBR)
,
RAYNAUD Florence I.
(Inst. of Cancer Res., London, GBR)
,
ECCLES Suzanne A.
(Inst. of Cancer Res., London, GBR)
,
GARRETT Michelle D.
(Inst. of Cancer Res., London, GBR)
,
COLLINS Ian
(Inst. of Cancer Res., London, GBR)
資料名:
Journal of Medicinal Chemistry
(Journal of Medicinal Chemistry)
巻:
59
号:
11
ページ:
5221-5237
発行年:
2016年06月09日
JST資料番号:
D0102A
ISSN:
0022-2623
CODEN:
JMCMAR
資料種別:
逐次刊行物 (A)
記事区分:
原著論文
発行国:
アメリカ合衆国 (USA)
言語:
英語 (EN)