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J-GLOBAL ID：201802275724164390
整理番号：18A0336697
M_4PAM in vivoツール化合物の開発における挑戦:近い類似体のVU0467154と予想外DMPKプロファイルの発見【Powered by NICT】
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs
Wood Michael R.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Wood Michael R.
(Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA)
,
Noetzel Meredith J.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Noetzel Meredith J.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Poslusney Michael S.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Melancon Bruce J.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Melancon Bruce J.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Tarr James C.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Lamsal Atin
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Chang Sichen
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Luscombe Vincent B.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Luscombe Vincent B.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Weiner Rebecca L.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Weiner Rebecca L.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Cho Hyekyung P.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Cho Hyekyung P.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Bubser Michael
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Jones Carrie K.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Jones Carrie K.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Jones Carrie K.
(Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Niswender Colleen M.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Niswender Colleen M.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Niswender Colleen M.
(Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Wood Michael W.
(Neuroscience Innovative Medicines, Astra Zeneca, 141 Portland Street, Cambridge, MA 02139, USA)
,
Engers Darren W.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Engers Darren W.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Brandon Nicholas J.
(Neuroscience Innovative Medicines, Astra Zeneca, 141 Portland Street, Cambridge, MA 02139, USA)
,
Duggan Mark E.
(Neuroscience Innovative Medicines, Astra Zeneca, 141 Portland Street, Cambridge, MA 02139, USA)
,
Conn P. Jeffrey
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Conn P. Jeffrey
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Conn P. Jeffrey
(Vanderbilt Kennedy Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Bridges Thomas M.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Bridges Thomas M.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Lindsley Craig W.
(Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, TN 37232, USA)
,
Lindsley Craig W.
(Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA)
,
Lindsley Craig W.
(Department of Chemistry, Vanderbilt University, Nashville, TN 37232, USA)
資料名：
Bioorganic & Medicinal Chemistry Letters
(Bioorganic & Medicinal Chemistry Letters)
巻： 27 号： 2 ページ： 171-175 発行年： 2017年
JST資料番号： W0248A ISSN： 0960-894X 資料種別： 逐次刊行物 (A)
記事区分： 原著論文 発行国： オランダ (NLD) 言語： 英語 (EN)
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