文献
J-GLOBAL ID:201802276179440588
整理番号:18A0129678
アルファ7ニコチン性アセチルコリン受容体特異的作動薬DMXBA(GTS 21)はニューロンγ-セクレターゼ活性の抑制とミクログリアのアミロイドβどん食作用の促進を介してAβ蓄積を低下させ,Alzheimer病のマウスモデルにおける認知障害を改善する【Powered by NICT】
Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer’s disease
著者 (19件):
Takata Kazuyuki
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Amamiya Takahide
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Mizoguchi Hiroaki
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Kawanishi Shohei
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Kuroda Eriko
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Kitamura Risa
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Ito Aina
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Saito Yuki
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Tawa Manami
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Nagasawa Tomofumi
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Okamoto Haruka
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Sugino Yuko
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Takegami Shigehiko
(Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Kitade Tatsuya
(Department of Analytical Chemistry, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Toda Yuki
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Kem William R.
(Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL, USA)
,
Kitamura Yoshihisa
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
,
Shimohama Shun
(Department of Neurology, Sapporo Medical University, School of Medicine, Sapporo, Japan)
,
Ashihara Eishi
(Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan)
資料名:
Neurobiology of Aging
(Neurobiology of Aging)
巻:
62
ページ:
197-209
発行年:
2018年
JST資料番号:
W0356A
ISSN:
0197-4580
資料種別:
逐次刊行物 (A)
記事区分:
原著論文
発行国:
オランダ (NLD)
言語:
英語 (EN)