文献
J-GLOBAL ID:201902248722311841
整理番号:19A0656305
3-((4-クロロ-3-メトキシフェニル)アミノ)-1-((3R,4S)-4-シアノテトラヒドロ-2H-ピラン-3-イル)-1H-ピラゾール-4-カルボアミド,高配位子効率的で有効なJanusキナーゼ1選択的阻害剤の好ましい薬物動力学的性質を有する選択的阻害剤)の発見【JST・京大機械翻訳】
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties
著者 (28件):
Siu Tony
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Brubaker Jason
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Fuller Peter
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Torres Luis
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Zeng Hongbo
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Close Joshua
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Mampreian Dawn M.
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Shi Feng
(Department of Chemistry, Pharmaron Beijing Co. Ltd)
,
Liu Duan
(Department of Discovery Process Chemistry, Merck & Co., Inc.)
,
Fradera Xavier
(Department of Modeling & Informatics, Merck & Co., Inc.)
,
Johnson Kevin
(Department of Molecular Biomarkers, Merck & Co., Inc.)
,
Bays Nathan
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
Kadic Elma
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
He Fang
(Department of Biology, Pharmaron Beijing Co. Ltd)
,
Goldenblatt Peter
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
Shaffer Lynsey
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
Patel Sangita B.
(Department of Structural Chemistry, Merck & Co., Inc.)
,
Lesburg Charles A.
(Department of Structural Chemistry, Merck & Co., Inc.)
,
Alpert Carla
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
Dorosh Lauren
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
Deshmukh Sujal V.
(Department of Pharmacokinetics Pharmacodynamics and Drug Metabolism, Merck & Co., Inc.)
,
Yu Hongshi
(Department of Discovery Pharmaceutical Sciences, Merck & Co., Inc.)
,
Klappenbach Joel
(Department of Molecular Biomarkers, Merck & Co., Inc.)
,
Elwood Fiona
(Department of Respiratory and Immunology, Merck & Co., Inc.)
,
Dinsmore Christopher J.
(Department of Medicinal Chemistry, Merck & Co., Inc.)
,
Fernandez Rafael
(Department of In Vitro Pharmacology, Merck & Co., Inc.)
,
Moy Lily
(Department of In Vivo Pharmacology, Merck & Co., Inc.)
,
Young Jonathan R.
(Department of Medicinal Chemistry, Merck & Co., Inc.)
資料名:
Journal of Medicinal Chemistry
(Journal of Medicinal Chemistry)
巻:
60
号:
23
ページ:
9676-9690
発行年:
2017年
JST資料番号:
D0102A
ISSN:
0022-2623
CODEN:
JMCMAR
資料種別:
逐次刊行物 (A)
記事区分:
原著論文
発行国:
アメリカ合衆国 (USA)
言語:
英語 (EN)