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J-GLOBAL ID:202202241765189743   整理番号:22A1160312

神経因性疼痛の潜在的な治療のための高選択性,CNS浸透性,および経口活性アダプター蛋白質2関連キナーゼ1(AAK1)阻害剤の新規クラスとしてのビアリールアルキルエーテルの発見と最適化【JST・京大機械翻訳】

Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain
著者 (43件):
Luo Guanglin
(Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, Connecticut, United States)
Chen Ling
(Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, Connecticut, United States)
Kostich Walter A.
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Hamman Brian
(Lexicon Pharmaceuticals, Texas, United States)
Allen Jason
(Lexicon Pharmaceuticals, Texas, United States)
Easton Amy
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Bourin Clotilde
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Gulianello Michael
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Lippy Jonathan
(Department of Lead Evaluation, Bristol Myers Squibb Company, New Jersey, United States)
Nara Susheel
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Pattipati Sreenivasulu Naidu
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Dandapani Kumaran
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Dokania Manoj
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Vattikundala Pradeep
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Sharma Vivek
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Elavazhagan Saravanan
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Verma Manoj Kumar
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Lal Das Manish
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Wagh Santosh
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Balakrishnan Anand
(Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Company, Connecticut, United States)
Johnson Benjamin M.
(Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Company, Connecticut, United States)
Santone Kenneth S.
(Department of Pharmaceutical Candidate Optimization, Bristol Myers Squibb Company, Connecticut, United States)
Thalody George
(Discovery Toxicology, Bristol Myers Squibb Company, New Jersey, United States)
Denton Rex
(Discovery Toxicology, Bristol Myers Squibb Company, New Jersey, United States)
Saminathan Hariharan
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Holenarsipur Vinay K.
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Kumar Anoop
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Rao Abhijith
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Putlur Siva Prasad
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Sarvasiddhi Sarat Kumar
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Shankar Ganesh
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Louis Justin V.
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Ramarao Manjunath
(Biocon-Bristol Myers Squibb Research and Development Centre, India)
Conway Charles M.
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Li Yu-Wen
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Pieschl Rick
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Tian Yuan
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Hong Yang
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Bristow Linda
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Albright Charles F.
(Department of Neuroscience Discovery Biology, Bristol-Myers Squibb Company, Connecticut, United States)
Bronson Joanne J.
(Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, Connecticut, United States)
Macor John E.
(Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, Connecticut, United States)
Dzierba Carolyn D.
(Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, Connecticut, United States)

資料名:
Journal of Medicinal Chemistry  (Journal of Medicinal Chemistry)

巻: 65  号:ページ: 4534-4564  発行年: 2022年 
JST資料番号: D0102A  ISSN: 0022-2623  CODEN: JMCMAR  資料種別: 逐次刊行物 (A)
記事区分: 原著論文  発行国: アメリカ合衆国 (USA)  言語: 英語 (EN)
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