研究者
J-GLOBAL ID:200901051641812732   更新日: 2024年08月17日

脇坂 尚宏

NAOHIRO WAKISAKA
研究キーワード (10件): 腫瘍免疫 ,  口蓋扁桃 ,  前転移ニッチ ,  免疫療法 ,  中咽頭癌 ,  センチネルリンパ節 ,  低侵襲手術 ,  頭頸部癌の転移機構 ,  頭頸部癌の発癌機構 ,  頭頸部癌
競争的資金等の研究課題 (19件):
  • 2021 - 2025 遺伝子発現シグネチャーによる頭頸部癌局所リンパ構造の免疫・ニッチ機構の解明
  • 2020 - 2022 モデルマウスを用いた免疫代謝解析に基づく頭頸部癌に対する抗腫瘍免疫活性化法の 開発
  • 2017 - 2021 上咽頭癌発癌ならびに多様性獲得分子機構の解析と新規治療法の開発
  • 2016 - 2020 内因性免疫による頭頸部ウイルス発癌における内分泌撹乱物質の関与と新規治療法の開発
  • 2017 - 2020 Epstein-Barrウイルスによる細胞老化関連分泌形質誘導機構の解明
全件表示
論文 (116件):
  • Naohiro Wakisaka, Makiko Moriyama-Kita, Satoru Kondo, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Tomokazu Yoshizaki. Lymph node metastasis regulation by peritumoral tonsillar tissue mitochondria-related pathway activation in oropharyngeal cancer. PLOS ONE. 2024. 19. 2. e0299750-e0299750
  • Naohiro Wakisaka, Makiko Moriyama-Kita, Satoru Kondo, Eiji Kobayashi, Takayoshi Ueno, Yosuke Nakanishi, Kazuhira Endo, Hisashi Sugimoto, Tomokazu Yoshizaki. Immune-Related Gene Expression Profile at Peritumoral Tonsillar Tissue Is Modified by Oropharyngeal Cancer Nodal Status. The American journal of pathology. 2023
  • Takahito Kondo, Kiyoaki Tsukahara, Daisuke Kawakita, Seiichi Yoshimoto, Kouki Miura, Masashi Sugasawa, Kazuaki Chikamatsu, Takashi Matsuzuka, Isao Oze, Morimasa Kitamura, et al. Macroscopic and multiple metastases in sentinel lymph node biopsy are respectively associated with poor prognosis in early oral cancer. International journal of clinical oncology. 2023. 28. 4. 512-520
  • Satoru Kondo, Atsushi Okabe, Takuya Nakagawa, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Hirotomo Dochi, Harue Mizokami, Yuki Kitagawa, Tomoya Kurokawa, et al. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2022. 166598-166598
  • Hirotomo Dochi, Satoru Kondo, Takayuki Murata, Masaki Fukuyo, Asuka Nanbo, Kousho Wakae, Wen-Ping Jiang, Toshihide Hamabe-Horiike, Mariko Tanaka, Takumi Nishiuchi, et al. Estrogen induces the expression of EBV lytic protein ZEBRA, a marker of poor prognosis in nasopharyngeal carcinoma. Cancer science. 2022. 113. 8. 2862-2877
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MISC (152件):
講演・口頭発表等 (11件):
  • Adjuvant chemotherapy with an oral fluoropyrimidine, S-1, following reduced- RADPLAT in advanced laryngeal cancer
    (14th Korea Japan Joint Meeting of Otorhinolaryngology-Head and Neck Surgery 2012)
  • どのように治療法を使い分けてゆくか. 化学放射線療法(動注化学療法)
    (第24回 日本喉頭科学会 2012)
  • Regulation of cis-presentation of CD8+ T-cell epitopes by EBV-encoded LMP1 through self-aggregation
    (14th International Symposiumu on EBV 2010)
  • Induction of receptor for advanced glycation end products by EpsteinBarr virus latent membrane protein 1 in nasopharyngeal carcinoma.
    (The12th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery 2008)
  • EBV LMP1induces and causes release of fibroblast Growth factor-2.
    (The10th Japan-Korea Joint Meeting of Otorhinolaryngology-Head and Neck Surgery 2004)
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