杉原数美

Sugihara Kazumi

研究分野 (1件)：薬系衛生、生物化学

競争的資金等の研究課題 (30件)：

2019 - 2023 尿を用いて簡便推定したキサンチン酸化酵素活性とその概日リズムを考慮した尿酸値制御
2017 - 2020 性特異的遺伝子発現のエピジェネティックな制御と環境化学物質・医薬品類の影響調査
2016 - 2019 生活用品に含まれる化学物質の核内受容体を介した内分泌への活性発現に至る複合影響
2016 - 2019 唾液中nicotine代謝物を用いた薬物代謝活性の簡便な推定法による禁煙治療設計
2014 - 2017 調剤現場における医薬品汚染の実態調査と医療関係者への曝露による健康影響予測

全件表示

論文 (52件)：

Yoshitaka Tayama, Kazumi Sugihara, Seigo Sanoh, Katsushi Miyake, Shigeyuki Kitamura, Shigeru Ohta. Xanthine oxidase and aldehyde oxidase contribute to allopurinol metabolism in rats. Journal of pharmaceutical health care and sciences. 2022. 8. 1. 31-31
Hiroyuki Kojima, Shinji Takeuchi, Seigo Sanoh, Katsuhiro Okuda, Shigeyuki Kitamura, Naoto Uramaru, Kazumi Sugihara, Kouichi Yoshinari. Profiling of bisphenol A and eight its analogues on transcriptional activity via human nuclear receptors. Toxicology. 2019. 413. 48-55
Naoki Takaoka, Seigo Sanoh, Katsuhiro Okuda, Yaichiro Kotake, Go Sugahara, Ami Yanagi, Yuji Ishida, Chise Tateno, Yoshitaka Tayama, Kazumi Sugihara, et al. Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions. Biochemical Pharmacology. 2018. 154. 28-38
Junpei Mori, Seigo Sanoh, Keiko Kashiwagi, Hideki Hanada, Mitsuki Shigeta, Ken-ichi T. Suzuki, Takashi Yamamoto, Yaichiro Kotake, Kazumi Sugihara, Shigeyuki Kitamura, et al. Developmental changes in drug-metabolizing enzyme expression during metamorphosis of Xenopus tropicalis. JOURNAL OF TOXICOLOGICAL SCIENCES. 2017. 42. 5. 605-613
Hitomi Ozaki, Kazumi Sugihara, Yoko Watanabe, Kyoko Moriguchi, Naoto Uramaru, Tomomichi Sone, Shigeru Ohta, Shigeyuki Kitamura. Comparative study of hydrolytic metabolism of dimethyl phthalate, dibutyl phthalate and di(2-ethylhexyl) phthalate by microsomes of various rat tissues. FOOD AND CHEMICAL TOXICOLOGY. 2017. 100. 217-224

MISC (22件)：

Seigo Sanoh, Naoki Takaoka, Katsuhiro Okuda, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Mami Kurosaki, Mineko Terao, Enrico Garattini, Shigeru Ohta. INHIBITORY EFFECTS OF DRUGS ON THE METABOLIC ACTIVITIES OF MOUSE AND HUMAN ALDEHYDE OXIDASE ISOFORMS. DRUG METABOLISM AND PHARMACOKINETICS. 2017. 32. 1. S83-S83
Seigo Sanoh, Yoshitaka Tayama, Kazumi Sugihara, Shigeyuki Kitamura, Shigeru Ohta. Significance of aldehyde oxidase during drug development: Effects on drug metabolism, pharmacokinetics, toxicity, and efficacy. DRUG METABOLISM AND PHARMACOKINETICS. 2015. 30. 1. 52-63
Seigo Sanoh, Mami Fujimoto, Yoichi Naritomi, Koya Sato, Akio Kawamura, Aya Horiguchi, Kazumi Sugihara, Shigeyuki Kitamura, Toru Horie, Chise Tateno, et al. PREDICTABILITY OF PLASMA CONCENTRATION-TIME PROFILES IN HUMANS USING CHIMERIC MICE WITH HUMANIZED LIVER. DRUG METABOLISM REVIEWS. 2014. 45. 60-60
Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara, Chise Tateno, Toru Horie, Shigeyuki Kitamura, Shigeru Ohta. Prediction of PK parameters of human using human chimeric mice. DRUG METABOLISM REVIEWS. 2011. 43. 50-50
Kazumi Sugihara, Hanaka Sako, Miyuki Arai, Seigo Sanoh, Shigeyuki Kitamura, Shigeru Ohta. Effect of Diet on Developmental Changes of Cytochrome P450 in Rat and Mouse. DRUG METABOLISM REVIEWS. 2010. 42. 134-134

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