研究者
J-GLOBAL ID:201101001400913717   更新日: 2024年11月01日

佐々木-濱田 幸恵

Sasaki-Hamada Sachie
ホームページURL (1件): http://kaken.nii.ac.jp/ja/r/00399320
研究分野 (1件): 神経科学一般
研究キーワード (3件): 経鼻製剤 ,  神経ペプチド ,  精神・神経疾患の病態と治療
競争的資金等の研究課題 (6件):
  • 2024 - 2027 オキシトシンに着目した遅発性産後うつ病の病態解明
  • 2018 - 2021 海馬神経ネットワークにおけるニューロメジンUの生理的役割とその応用
  • 2016 - 2020 脳内ドーパミン神経の脱落により生じる低体重の機序解明
  • 2015 - 2018 中枢作用性ペプチド製剤の開発と経鼻投与による臨床応用に向けた薬理学的基盤研究
  • 2012 - 2015 治療抵抗性うつ病改善を目標としたGLPー2の薬理学的基盤研究
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論文 (35件):
  • Hayuma Otsuka, Sachie Sasaki-Hamada, Hitoshi Ishibashi, Jun-Ichiro Oka. Hippocampal acetylcholine receptor activation-dependent long-term depression in streptozotocin-induced diabetic rats. Neuroscience letters. 2024. 822. 137650-137650
  • Junpei Takahashi, Yudai Ueta, Daisuke Yamada, Sachie Sasaki-Hamada, Takashi Iwai, Tomomi Akita, Chikamasa Yamashita, Akiyoshi Saitoh, Jun-Ichiro Oka. Intracerebroventricular administration of oxytocin and intranasal administration of the oxytocin derivative improve β-amyloid peptide (25-35)-induced memory impairment in mice. Neuropsychopharmacology reports. 2022
  • Sachie Sasaki-Hamada, Emi Sanai, Mariko Kanemaru, Gaku Kamanaka, Jun-Ichiro Oka. Long-term exposure to high glucose induces changes in the expression of AMPA receptor subunits and glutamate transmission in primary cultured cortical neurons. Biochemical and biophysical research communications. 2022. 589. 48-54
  • Sachie Sasaki-Hamada, Yoshimichi Maeno, Mizuki Yabe, Hitoshi Ishibashi. Neuromedin U modulates neuronal excitability in rat hippocampal slices. Neuropeptides. 2021. 89. 102168-102168
  • Sachie Sasaki-Hamada, Ayumu Fujiwara, Show Satoh, Takashi Iwai, Jun-Ichiro Oka. GLP-2 restores impairments in spatial working memory and hippocampal LTD via the MEK/ERK pathway in juvenile-onset diabetes rats. Behavioural brain research. 2021. 406. 113235-113235
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MISC (9件):
  • Funane Taichi, Sasaki-Hamada Sachie, Horiguchi Michiko, Nakao Yusuke, Sasaki Rie, Yamashita Chikamasa, Oka Jun-Ichiro. The intranasally administered neuromedin U derivative induced memory improvement. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S230
  • Jun-Ichiro Oka, Sachie Sasaki-Hamada, Michiko Horiguchi, Ryuji Nakamura, Yusuke Nakao, Chikamasa Yamashita. Therapeutic potential of the intranasally administered GLP-2 derivative for the treatment of depression. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2016. 130. 3. S53-S53
  • Kinzo Matsumoto, Yimin Niu, Qi Zhao, Hironori Fujiwara, Sachie Hamada, Jun-Ichiro Oka. Chotosan and cognitive deficits attributable to aging and diabetes. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 51-51
  • Banri Segawa, Hiroaki Sacai, Sachie Hamada, Jun-Ichiro Oka. Effects of memantine, a NMDA receptor antagonist, on learning behavior and synaptic plasticity in juvenile diabetes mellitus rats. 2012. 118. 140-140
  • Azusa Sugiyama, Akiyoshi Saitoh, Misa Yamada, Takashi Iwai, Tomio Hashimoto, Yuya Makino, Masanori Ohashi, Sachie Hamada, Jun-Ichiro Oka, Masatoshi Inagaki, et al. Riluzole produces distinct anxiolytic-like effects in rats through blockade of voltage-activated sodium channels. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 68-68
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