研究者
J-GLOBAL ID:201401001532984100   更新日: 2024年10月03日

劉 莉

リュウ リ | Liu Li
所属機関・部署:
職名: 特任教授
研究分野 (3件): 生体医工学 ,  生体材料学 ,  心臓血管外科学
競争的資金等の研究課題 (19件):
  • 2022 - 2031 フォトニクス生命工学研究開発拠点
  • 2022 - 2025 心筋ー間葉系幹細胞複合型組織の構築及び虚血性心筋症への再生治療
  • 2022 - 2025 創薬用複合型心筋組織電学機能評価システムの開発
  • 2022 - 2025 心筋組織機能評価用新規デバイスを用いた医薬品安全・有効性評価
  • 2020 - 2023 重症心不全を根治する“3D Mini Heart” 創成
全件表示
論文 (65件):
  • Junjun Li, Menglu Li, Yasunori Nawa, Yuting Liu, Kazuki Bando, Ying Hua, Lifu Sun, Satoshi Fujita, Yoshiki Sawa, Katsumasa Fujita, et al. Label-Free Raman Spectroscopy for Assessing Purity and Maturation of hiPSC-Derived Cardiac Tissue. Analytical Chemistry. 2024. 96. 39. 15765-15772
  • Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Lifu Sun, Akima Harada, Ying Hua, Nagako Sougawa, Akiko Tabata, Li Liu, et al. Development of composite functional tissue sheets using hiPSC-CMs and hADSCs to improve the cardiac function after myocardial infarction. Bioactive Materials. 2024. 37. 533-548
  • Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, et al. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment. iScience. 2024. 27. 2. 108992-108992
  • Jingbo Zhang, Junjun Li, Xiang Qu, Yuting Liu, Akima Harada, Ying Hua, Noriko Yoshida, Masako Ishida, Akiko Tabata, Lifu Sun, et al. Development of a thick and functional human adipose-derived stem cell tissue sheet for myocardial infarction repair in rat hearts. Stem cell research & therapy. 2023. 14. 1. 380-380
  • Akihiro Hashida, Taro Nakazato, Toshimasa Uemura, Li Liu, Shigeru Miyagawa, Yoshiki Sawa, Masahiro Kino-oka. Effect of morphological change on the maturation of human induced pluripotent stem cell-derived cardiac tissue in rotating flow culture. Regenerative Therapy. 2023. 24. 479-488
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MISC (31件):
  • 植村寿公, 植村寿公, 橋田礼博, 中里太郎, LIU Li, 宮川繁, 澤芳樹, 紀ノ岡正博. 回転浮遊培養によるヒトiPS細胞由来心筋組織の成熟化メカニズムの解明. 日本再生医療学会総会(Web). 2024. 23rd
  • Kazuhiro Aiba, Liu Li, Kensuke Kato, Norio Nakatsuji. SCAD-MT Cardiomyocyte: Human Pluripotent Stem Cell-Derived Cardiomyocyte Micro-tissues That Show Maturation and Functional Stability Promoted by Using Aligned Nanofibers. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS. 2017. 88. 235-235
  • 劉 莉. Low cell-matrix adhesion microenvironment promote maintain of high-pluripotency state stem cells. 10 Years of iPSCs Cell Symposium. 2016
  • 劉 莉. Engineered anisotropic and 3-demensional hiPS-derived cardiac tissue-like construct for drug assessment and cardiac disease repairing. 13th International Society for Stem Cell Research (ISSCR) Annual Meeting. 2016
  • 劉 莉. Creating functional anisotropic and 3D tissue-like construct using induced pluripotent stem cell-derived cardiomyocytes. CiRA/ISSCR 2016 International Symposia. 2016
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特許 (19件):
  • 細胞の凝集体の製造方法、凝集体の集団、細胞の培養方法
  • 人工心筋組織、その使用、及びその製造方法
  • 多層重厚組織体、その製造方法及びその用途
  • 細胞培養方法及びその装置
  • ラマン散乱を用いた心筋細胞の評価方法
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書籍 (1件):
  • Fabrication of Thick and Anisotropic Cardiac Tissue on Nanofibrous Substrate for Repairing Infarcted Myocardium
    Humana, New York, NY
講演・口頭発表等 (15件):
  • Human iPSC derived cardiac tissue matured by spontaneous traveling waves for improved drug assessment.
    (American Heart Association Scientific Session,)
  • Micro-/Nanofibrous Matrices for pluripotent stem cell and cardiac tissue transplantation
    (MU-OU joint Symposium 2021)
  • 機能性iPS細胞由来心筋組織を用いた心不全再生医療法の開発
    (第20回日本再生医療学会)
  • ナノファイバーを用いたヒトiPS細胞由来心筋組織の構築及び再生医療への応用
    (第58回日本人工臓器学会 2020)
  • Circulating traveling waves enhance the maturation of hipsc-derived cardiomyocytes in self-organized tissue ring
    (the 8th Meeting of the International Federation for Artificial Organs. 2019)
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